From: Histone deacetylase inhibitors induce apoptosis in human eosinophils and neutrophils
 | EC50 (nM) |  | |
---|---|---|---|
Apoptosis | Eosinophils | neutrophils | P value |
GM-CSF | Â | Â | Â |
   0.01 ng/ml | 79 ± 2 |  |  |
   0.1 ng/ml | 102 ± 1 |  |  |
   10 ng/ml | 93 ± 1 | 123 ± 9 | 0.0042 |
IL-5 | 92 ± 8 |  |  |
Constitutive | 34 ± 10 | 97 ± 22 | 0.0007 |
Budesonide | 32 ± 17 | 99 ± 7 | 0.026 |
Fluticasone | 47 ± 15 | 100 ± 11 | 0.017 |
Mometasone | 20 ± 5 | 87 ± 9 | < 0.0001 |
Fas | 31 ± 10 |  |  |