Figure 1From: Early lactate clearance is associated with biomarkers of inflammation, coagulation, apoptosis, organ dysfunction and mortality in severe sepsis and septic shockMean biomarker levels averaged over 72 hours based on lactate clearance quartile. The mean levels of pro-inflammatory markers interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α), intercellular adhesion molecule-1 (ICAM-1), and high mobility group box-1 (HMGB-1); anti-inflammatory markers interleukin-1 receptor antagonist (IL-1ra) and interleukin-10 (IL-10); coagulation marker D-Dimer; and apoptosis marker Caspase-3 are significantly lower over 72 hours with higher lactate clearance quartiles.Back to article page