Figure 3

Catwalk analysis performed on CARR-treated PTPH1-WT and KO mice. a) The print area parameter was not modulated by CARR injection in both genotypes at 1 and 5 hours post-treatment; a slight CARR-induced decrease in print area was detectable in both genotypes at 5 and 24 hours post-treatment and it was statistically significant only in KO mice group, at both time points. A trend in genotype-related difference between CARR-treated animals (WT and KO) was recorded 24 h after challenge. 2way Anova followed by Paired T-test *:p < 0.05; **:p < 0.01; ***:p < 0.001. b) The duty cycle parameter was significantly altered by CARR injection in WT mice 1 h post-treatment, but no difference was detected in KO mice group. No CARR-induced or genotype-induced differences in duty cycle were detectable 3 hours after CARR treatment. A slight CARR-induced decrease duty cycle was detectable in WT group at 5 hours post-treatment, while a strong down-regulation of this parameter was recorded in KO group. 24 hours after CARR treatment both genotypes displayed a decrease percentage of duty cycle and no genotype-related differences were detectable between WT and KO CARR-treated groups. 2way Anova followed by Paired T-test *:p < 0.05; **:p < 0.01; ***:p < 0.001.