Figure 2

Behavioral tests performed on CARR-treated PTPH1-WT and KO mice. a) Withdrawal force measured at the Von Frey test was significantly decreased by CARR treatment in both WT and KO mice, starting 1 hour after CARR injection, till 24 hours. The peak was reached 5 hours after CARR treatment. b) The withdrawal time measured at Hargreaves' test was significantly decreased by CARR treatment in both WT and KO mice, starting 1 hour after CARR injection, till 24 hours. The peak of response was reached 5 hours after CARR treatment. No genotype-related differences were detectable between WT and KO CARR-treated groups at both tests. 2way Anova followed by Paired T-test *:p < 0.05; **:p < 0.01; ***:p < 0.001. V-WT: vehicle-treated PTPH1-WT mice; C-WT: CARR-treated PTPH1-WT mice; V-KO: vehicle-treated PTPH1-KO mice; C-KO: CARR-treated PTPH1-KO mice.