Figure 2From: Modulation of expression and cellular distribution of p21 by macrophage migration inhibitory factorrMIF rescues cells from basal and SNP induced apoptosis. The effect of rMIF on apoptosis of MDF was examined using cytometric detection of annexin V/PI dual labeling. MIF-/- MDF demonstrated increased rates of spontaneous apoptosis which was reduced following treatment with 100 ng/ml rMIF. Similarly, rMIF treatment abrogated SNP (0.25 mM) induced apoptosis in both MIF-/- and wt MDF, (N = 3, * P < 0.05).Back to article page