Changes in ion transport in inflammatory disease

Journal of Inflammation

Table 1 Effects of inflammatory mediators on epithelial ion transport protein activity and expression.

Type of ion transport system [references]	Respiratory tract								Gut									Kidney
	TNF	IL-1	IL-4	IL-9	IL-13	IFNg	TGF	Leukotrienes	TNF	IL-1	IL-3	IL-4	IL-10	IFNg	TGF	Subst P	bradykinin	IL-1	TGF	bradykinin	epoxide
CFTR
activity [9,23,24,49,50,82,83,93]		+/- ^a,b	+			-	-	+^a	+ ^a,b	+ ^a,b	+ ^a	-	-	-	-	+ ^a,c	+		-
expression [9, 24, 49, 50, 82, 83, 86, 93]		+	+			-	-		-	+/-		-		-	-				-
ENaC
activity [21, 24, 45, 46, 48, 49]	+/- ^a,b	-	-				+													-
expression [44, 45, 46, 47, 49, 89, 90]	-	+/-	-				-		-	-				-
Na/K ATPase
activity [30, 56, 57, 58, 59, 88, 98, 99, 108, 109]								+^a	-					-	-			-^a,b		+/-^a	-
expression [47, 48, 87, 88, 91, 100]		+					+		-^a	-				-				-
Non CFTR Cl ^- channel
activity [51, 133]	+	+				+															+
expression [51, 52, 113]			+	+	+	+															+
Na/K 2Cl ^- co-transporter									-
activity [88]									-
expression [87, 88, 91]									-^a	+				-

+ = increase
-=decrease
+/- = increase or decrease depending on experimental conditions and possibly second messenger involved
^a mediated through PGE2
^b mediated through NO
^c mediated through histamine

ISSN: 1476-9255