Articles

Characterization of inflammation and immune cell modulation induced by low-dose LPS administration to healthy volunteers

Human in vivo models of systemic inflammation are used to study the physiological mechanisms of inflammation and the effect of drugs and nutrition on the immune response. Although in vivo lipopolysaccharide (LPS)...

Authors: Marlous R Dillingh, Eveline P van Poelgeest, Karen E Malone, Elles M Kemper, Erik S G Stroes, Matthijs Moerland and Jacobus Burggraaf

Impact of rosuvastatin treatment on reduction of thrombus burden in rat acute inferior vena cava stenosis

This study tested the hypothesis that rosuvastatin reduces thrombus burden through inhibiting inflammation and suppressing reactive oxygen species (ROS) generation in an inferior vena cava stenosis (IVC_ST)-induce...

Authors: Kun-Chen Lin, Hung-I Lu, Yung-Lung Chen, Tzu-Hsien Tsai, Li-Teh Chang, Steve Leu, Shu-Yuan Hsu, Cheuk-Kwan Sun, Han-Tan Chai, Hsueh-Wen Chang, Chia-Lo Chang, Hong-Hwa Chen and Hon-Kan Yip

P2X7 receptors are a potential novel target for anti-glioma therapies

Human gliomas pose significant morbidity and mortality to those afflicted by them, and currently there are no curative treatment modalities available for these highly invasive tumours.

Authors: Mastura Monif, Terence J O’Brien, Kate J Drummond, Christopher A Reid, Simon V Liubinas and David A Williams

A cardiopulmonary bypass with deep hypothermic circulatory arrest rat model for the investigation of the systemic inflammation response and induced organ damage

Cardiopulmonary bypass (CPB) is a commonly used technique in cardiac surgery. CPB is however associated with a strong induction of systemic inflammatory response syndrome (SIRS) which in conjunction with ische...

Authors: Melanie Engels, Esra Bilgic, Antonio Pinto, Edwin Vasquez, Lena Wollschläger, Holger Steinbrenner, Kristine Kellermann, Payam Akhyari, Artur Lichtenberg and Udo Boeken

Chronic inflammation and cancer: potential chemoprevention through nuclear factor kappa B and p53 mutual antagonism

Activation of nuclear factor-kappa B (NF- κ B) as a mechanism of host defense against infection and stress is the central mediator of inflammatory responses. A normal (acute) inflammatory response is activated on...

Authors: Srabani Pal, Ashish Bhattacharjee, Asif Ali, Narayan C Mandal, Subhash C Mandal and Mahadeb Pal

Decreased percentage of CD4⁺Foxp3⁺TGF-β⁺ and increased percentage of CD4⁺IL-17⁺ cells in bronchoalveolar lavage of asthmatics

Asthma is a chronic inflammatory disorder of the airways with the proven role of Th2 cells in its pathogenesis. The role and characteristic of different subsets of CD4⁺ cells is much less known.

Authors: Adam Barczyk, Wladyslaw Pierzchala, Gaetano Caramori, Ryszard Wiaderkiewicz, Marcin Kaminski, Peter J Barnes and Ian M Adcock

Elevated CXCL-8 expression in bronchoalveolar lavage correlates with disease severity in patients with acute respiratory distress syndrome resulting from tuberculosis

Tuberculosis (TB) is a rare but known cause of acute respiratory distress syndrome (ARDS). The role of inflammatory cytokines in the progression of ARDS in TB patients is unknown.

Authors: Seyed Mohamad Reza Hashemian, Esmaeil Mortaz, Payam Tabarsi, Hamidreza Jamaati, Zohreh Maghsoomi, Adnan Khosravi, Johan Garssen, Mohamad Reza Masjedi, Ali Akbar Velayati, Gert Folkerts, Peter J Barnes and Ian M Adcock

Role of toll-like receptors in human iris pigment epithelial cells and their response to pathogen-associated molecular patterns

Toll-like receptor (TLR) activation is hypothesized to contribute to inflammatory eye disease including uveitis, yet the distribution pattern of TLRs in human uveal tissues remains poorly described. The purpos...

Authors: Kelly Mai, Jeanie JY Chui, Nick Di Girolamo, Peter J McCluskey and Denis Wakefield

Heat shock protein 70 down-regulates the production of toll-like receptor-induced pro-inflammatory cytokines by a heat shock factor-1/constitutive heat shock element-binding factor-dependent mechanism

Heat shock protein 70 (Hsp70) is an intracellular chaperone protein with regulatory and cytoprotective functions. Hsp70 can also be found in the extracellular milieu, as a result of active secretion or passive...

Authors: Eduardo Ferat-Osorio, Aldair Sánchez-Anaya, Mireille Gutiérrez-Mendoza, Ilka Boscó-Gárate, Isabel Wong-Baeza, Rodolfo Pastelin-Palacios, Gustavo Pedraza-Alva, Laura C Bonifaz, Pedro Cortés-Reynosa, Eduardo Pérez-Salazar, Lourdes Arriaga-Pizano, Constantino López-Macías, Yvonne Rosenstein and Armando Isibasi

Insulin alleviates the inflammatory response and oxidative stress injury in cerebral tissues in septic rats

Sepsis-associated encephalopathy (SAE) is a diffuse brain dysfunction that occurs secondary to infection in the body without overt central nervous system (CNS) infection. SAE is frequently encountered in criti...

Authors: Qiyi Chen, Wenkui Yu, Jiangliang Shi, Juanhong Shen, Tao Gao, Juanjuan Zhang, Fengchan Xi, Jieshou Li and Ning Li

Early effects of Staphylococcus aureus biofilm secreted products on inflammatory responses of human epithelial keratinocytes

Chronic wounds such as diabetic foot ulcers, pressure ulcers, and venous leg ulcers contribute to a considerable amount of mortality in the U.S. annually. The inability of these wounds to heal has now been ass...

Authors: Amy Tankersley, Mark Barton Frank, Melissa Bebak and Robert Brennan

Effect of remote ischemic post-conditioning on systemic inflammatory response and survival rate in lipopolysaccharide-induced systemic inflammation model

Remote ischemic preconditioning (RIPC) and postconditioning (RpostC) have protective effects on ischemia and reperfusion injury. The effects have been reported to activate heme oxygenase-1 (HO-1) and attenuate...

Authors: Yun-Hee Kim, Dae-Wui Yoon, Je-Hyeong Kim, Jeoung-Hyuk Lee and Choon-Hak Lim

Green Tea Extract (GTE) improves differentiation in human osteoblasts during oxidative stress

Oxidative stress is involved in the pathogenesis of bone diseases such as osteoporosis, which has a high coincidence with fractures in elderly. Several studies showed positive effects of herbal bioactive subst...

Authors: Helen Vester, Nina Holzer, Markus Neumaier, Schyschka Lilianna, Andreas K Nüssler and Claudine Seeliger

Differential regulation of anti-inflammatory genes by p38 MAP kinase and MAP kinase kinase 6

Conventional p38α inhibitors have limited efficacy in rheumatoid arthritis, possibly because p38 blockade suppresses the counter-regulatory mechanisms that limit inflammation. In contrast, targeting the upstre...

Authors: Deepa Hammaker, David L Boyle, Katharyn Topolewski and Gary S Firestein

The synergistic effect of homocysteine and lipopolysaccharide on the differentiation and conversion of raw264.7 macrophages

Macrophages play pivotal roles in the progression of atherosclerosis (AS) and their heterogeneous differentiation patterns have been studied extensively. The classical subtype of activated macrophage, M1, prom...

Authors: Shanshan Gao, Lijun Wang, Weimin Liu, Yue Wu and Zuyi Yuan

Chorioamnionitis (ChA) modifies CX3CL1 (fractalkine) production by human amniotic epithelial cells (HAEC) under normoxic and hypoxic conditions

Chemokine CX3CL1 possesses unique properties, including combined adhesive and chemotactic functions. Human amniotic epithelial cells (HAEC) show expression of CX3CL1 receptor (CX3CR1) and produce CX3CL1 in res...

Authors: Dariusz Szukiewicz, Jan Kochanowski, Tarun Kumar Mittal, Michal Pyzlak, Grzegorz Szewczyk and Krzysztof Cendrowski

The effect of thiamine deficiency on inflammation, oxidative stress and cellular migration in an experimental model of sepsis

Sepsis is a prevalent condition in critically ill patients and may be associated with thiamine deficiency (TD). The aim of this study was to evaluate the effect of TD on inflammation, oxidative stress and cell...

Authors: José Antenor Araújo de Andrade, Carlos Roberto Machado Gayer, Natália Pereira de Almeida Nogueira, Márcia Cristina Paes, Vera Lúcia Freire Cunha Bastos, Jayme da Cunha Bastos Neto, Sílvio Caetano Alves Jr, Raphael Molinaro Coelho, Mariana Gysele Amarante Teixeira da Cunha, Rachel Novaes Gomes, Márcia Barbosa Águila, Carlos Alberto Mandarim-de-Lacerda, Patrícia Torres Bozza and Sérgio da Cunha

Inhibitory effects of heat shock protein 90 blockade on proinflammatory human Th1 and Th17 cell subpopulations

Heat shock protein 90 (Hsp90), a chaperone that regulates activity of many client proteins responsible for cellular growth, differentiation, and apoptosis, has been proposed as an important clinical and precli...

Authors: Stefan Tukaj, Detlef Zillikens and Michael Kasperkiewicz

Functional characterisation of human pulmonary monocyte-like cells in lipopolysaccharide-mediated acute lung inflammation

We have previously reported the presence of novel subpopulations of pulmonary monocyte-like cells (PMLC) in the human lung; resident PMLC (rPMLC, HLA-DR⁺CD14⁺⁺CD16⁺cells) and inducible PMLC (iPMLC, HLA-DR⁺CD14⁺⁺C...

Authors: Mairi Brittan, Laura C Barr, Niall Anderson, Andrew Conway Morris, Rodger Duffin, John A Marwick, Fiona Rossi, Shonna Johnson, Kev Dhaliwal, Nikhil Hirani, Adriano G Rossi and A John Simpson

Expression of pro-inflammatory mediators is inhibited by an avocado/soybean unsaponifiables and epigallocatechin gallate combination

Osteoarthritis (OA) is characterized by inflammation, joint immobility, and pain. Non-pharmacologic agents modulating pro-inflammatory mediator expression offer considerable promise as safe and effective treat...

Authors: Stacy L Ownby, Lowella V Fortuno, Angela Y Au, Mark W Grzanna, Ann M Rashmir-Raven and Carmelita G Frondoza

A significant correlation between C - reactive protein levels in blood monocytes derived macrophages versus content in carotid atherosclerotic lesions

Atherosclerosis is a complex disease involving different cell types, including macrophages that play a major role in the inflammatory events occurring in atherogenesis. C-Reactive Protein (CRP) is a sensitive ...

Authors: Marielle Kaplan, Shadi Hamoud, Yevgeny Tendler, Edna Meilin, Aviva Lazarovitch, Samy Nitecki and Tony Hayek

Anti-inflammatory effects of resolvin-D1 on human corneal epithelial cells: in vitro study

This study evaluated the anti-inflammatory effects of Resolvin-D1 (RV-D1) and its mechanism of action in human corneal epithelial (HCE) cells.

Authors: Nir Erdinest, Haim Ovadia, Ran Kormas and Abraham Solomon

Combination therapy with ampicillin and azithromycin in an experimental pneumococcal pneumonia is bactericidal and effective in down regulating inflammation in mice

Emergence of multidrug resistance among Streptococcus pneumoniae (SP), has limited the available options used to treat infections caused by this organism. The objective of this study was to compare the role of mo...

Authors: Arnab Majhi, Kiran Kundu, Rana Adhikary, Madhubanti Banerjee, Sayantika Mahanti, Anirban Basu and Biswadev Bishayi

Salivary histatin 3 inhibits heat shock cognate protein 70-mediated inflammatory cytokine production through toll-like receptors in human gingival fibroblasts

Salivary histatins are bioactive peptides related to the innate immune system associated with antimicrobial activities. However, very little is known about the physiological and biological functions of histati...

Authors: Yasuhiro Imamura and Pao-Li Wang

Expression and activation of toll-like receptor 3 and toll-like receptor 4 on human corneal epithelial and conjunctival fibroblasts

Toll-like receptors (TLRs) are recognized as important contributors to the initiation and modulation of the inflammatory response in the eye. This study investigated the precise expression patterns and functio...

Authors: Nir Erdinest, Gal Aviel, Eli Moallem, Irene Anteby, Claudia Yahalom, Hadas Mechoulam, Haim Ovadia and Abraham Solomon

Relationship between vitamin D status and the inflammatory state in patients with chronic spontaneous urticaria

Chronic spontaneous urticaria (CSU) is an immune-inflammatory disease, characterized by acute phase response (APR) and immune activation. There has been increasing evidence showing that vitamin D deficiency/in...

Authors: Alicja Grzanka, Edyta Machura, Bogdan Mazur, Maciej Misiolek, Jerzy Jochem, Jacek Kasperski and Alicja Kasperska-Zajac

A comparison of adipose and bone marrow-derived mesenchymal stromal cell secreted factors in the treatment of systemic inflammation

Bone marrow-derived mesenchymal stromal cells (BMSCs) are a cell population of intense exploration for therapeutic use in inflammatory diseases. Secreted factors released by BMSCs are responsible for the resol...

Authors: Jessica S Elman, Matthew Li, Fangjing Wang, Jeffrey M Gimble and Biju Parekkadan

Expression of AIM2 is high and correlated with inflammation in hepatitis B virus associated glomerulonephritis

Innate immunity is the first line of defense against invasive microbial infection, and AIM2 plays an important role in this process by sensing double-stranded DNA viruses. However, the role of AIM2 in regulati...

Authors: Wenjun Du, Junhui Zhen, Zhaomin Zheng, Shumin Ma and Shijun Chen

Differential expression of prolyl hydroxylase 1 in patients with ulcerative colitis versus patients with Crohn’s disease/infectious colitis and healthy controls

Inhibition of prolyl hydroxylases (PHDs) leads to the induction of a transcriptional program that, in the gut, promotes intestinal epithelial cell survival. PHD inhibitors have recently been suggested as a pro...

Authors: Sophie Van Welden, Debby Laukens, Liesbeth Ferdinande, Martine De Vos and Pieter Hindryckx

Prenatal exposure to lipopolysaccharide results in myocardial remodelling in adult murine offspring

The epigenetic plasticity hypothesis indicates that pregnancy exposure may result in adult-onset diseases, including hypertension, diabetes and cardiovascular disease, in offspring. In a previous study, we dis...

Authors: Yanling Wei, Wenhua Du, Xiuqin Xiong, Xiaoyan He, Ping Yi, Youcai Deng, Dongfeng Chen and Xiaohui Li

Oleic acid inhibits lung Na/K-ATPase in mice and induces injury with lipid body formation in leukocytes and eicosanoid production

Acute respiratory distress syndrome (ARDS) can emerge from certain pathologies, such as sepsis, fat embolism and leptospirosis, in which the levels of unesterified fatty acids are increased in the patient’s pl...

Authors: Cassiano Felippe Gonçalves-de-Albuquerque, Patrícia Burth, Adriana Ribeiro Silva, Isabel Matos Medeiros de Moraes, Flora Magno de Jesus Oliveira, Ricardo Erthal Santelli, Aline Soares Freire, Patrícia Torres Bozza, Mauricio Younes-Ibrahim, Hugo Caire de Castro-Faria-Neto and Mauro Velho de Castro-Faria

TLR2 stimulation induces cardiac inflammation but not cardiac depression in vivo

Bacteria such as Staphylococcus aureus induce myocardial dysfunction in vivo. To rectify conflicting evidence about the role of TLR2 signaling and cardiac dysfunction, we hypothesized that the specific TLR2 agoni...

Authors: Olaf Boehm, Pascal Knuefermann, Johannes Plueck, Markus Schwederski, Heidi Ehrentraut, Sied Kebir, Ralph Lohner, Markus Velten, Siegfried Morath, Alexander Koch, Kai Zacharowski, Christian Grohé, Andreas Hoeft, Georg Baumgarten and Rainer Meyer

BMP4 is increased in the aortas of diabetic ApoE knockout mice and enhances uptake of oxidized low density lipoprotein into peritoneal macrophages

BMP4, a member of the transforming growth factor-beta superfamily, is upregulated in the aortas of diabetic db/db mice. However, little is known about its role in diabetic atherosclerosis. Therefore, we examin...

Authors: Mitsuhisa Koga, Atsushi Yamauchi, Yuki Kanaoka, Ryusuke Jige, Anna Tsukamoto, Nao Teshima, Tsuyoshi Nishioku and Yasufumi Kataoka

Low Serum retinol-binding protein-4 levels in acute exacerbations of chronic obstructive pulmonary disease at intensive care unit admission is a predictor of mortality in elderly patients

Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are thought to be associated with increased mortality in elderly patients. Low retinol-binding protein-4 (RBP4) is associated with a high r...

Authors: Qihui Jin, Yueliang Chen, Yufeng Lou and Xiaojun He

Protective effect of Zhuyeqing liquor, a Chinese traditional health liquor, on acute alcohol-induced liver injury in mice

The study first evaluated the hepatoprotective effect of Zhuyeqing Liquor (ZYQL) against acute alcohol-induced liver injury in mice. Animals were administered orally with 50% alcohol 12 ml/kg at 4 h after the ...

Authors: Hong-ying Gao, Jian Huang, Hang-yu Wang, Xiao-wei Du, Suo-ming Cheng, Ying Han, Li-fei Wang, Guo-yu Li and Jin-hui Wang

Effects of two different strategies of fluid administration on inflammatory mediators, plasma electrolytes and acid/base disorders in patients undergoing major abdominal surgery: a randomized double blind study

Administration of normal saline might increase circulating levels of pro-inflammatory cytokines and may cause variation of plasmatic electrolytic and hyperchloremic acidosis, which in turn can impair renal fun...

Authors: Carlo Alberto Volta, Alessandro Trentini, Lucia Farabegoli, Maria Cristina Manfrinato, Valentina Alvisi, Franco Dallocchio, Elisabetta Marangoni, Raffaele Alvisi and Tiziana Bellini

Considerations for therapeutic intervention models of pulmonary fibrosis

Authors: JA Wilder, M Doyle-Eisele, KM Gott, Y Shi, R Guilmette, A Gigliotti, J McDonald and IO Rosas

Steroid insensitive respiratory inflammation - an acute tobacco smoke model

Authors: Hemanth Ramaprakash, Jason Riley and Navin L Rao

A translational approach to test anti-inflammatory drugs in a LPS induced acute lung inflammation model in the common marmoset (Callithrix jacchus)

Authors: S Seehase, S Switalla, V Neuhaus, M Zöller, FJ Kaup, C Schlumbohm, E Fuchs, HD Lauenstein, K Sewald, JM Hohlfeld, A Braun and S Knauf

Characterization of MMP-9 and -12 KO mice in a model of acute smoke exposure

Authors: Franklin J Schlerman, John E Kubera, Stephen P Pazdziorko, Michael R Bowman, Bruce A Jacobson, Margaret Fleming, Cara MM Williams and Joseph P Sypek

Antiviral effect of eosinophils in respiratory tract infection with influenza virus in mice

Authors: Suzanne M Bal, Annemiek Dijkhuis, Koen van der Sluijs and Rene Lutter

Mouse model of HDM induced airway inflammation + influenza or RSV. Effects of steroid

Authors: Dave Lamb, Christina Muir, Debbie Chappell, Hiroki Mori, Nicole Parker, Katy Hulland, Dominique Westbrook, Umar Burki, Jenny Hincks, Tony White, Vittorio Spampinato, Helen Bright and Steve Evans

Impaired anti-viral immune response to human rhinovirus 1B infection in chronic allergic airway inflammation does not manifest in asthma exacerbation

Authors: Sabine Rochlitzer, Heinz-Gerd Hoymann, Armin Braun and Meike Müller

Mast cell mediators cause the early allergic bronchoconstriction in guinea pigs in vivo: a model of relevance to asthma

Authors: Jason P Riley, Barbara Fuchs, Lisa Sjöberg, Gunnar P Nilsson, Lars Karlsson, Sven-Erik Dahlén, Navin L Rao and Mikael Adner

Development of a model of Ascaris Suum antigen-induced pulmonary inflammation in nonhuman primates

Authors: Andrea G Bree, Franklin J Schlerman, Michael D Wadanoli, I-Ming Wang, Samuel J Goldman and Joseph P Sypek

A novel TLR-8 agonist attenuates nasal symptoms/congestion in both dog and human allergen challenge studies

Authors: Edward G Barrett, Karin Rudolph, Maura Matthews, Greg Dietsch and Robert Hershberg

Time-course of inflammation and allergic bronchoconstrictor response in a model of ovalbumin-induced rapid pulmonary inflammation in Brown Norway rats

Authors: Sorif Uddin, Sara Hughes and Edith Hessel

Alternaria alternata induced inflammatory lung responses: a novel in vivo PK/PD model

Authors: Malgorzata Gil, Michael Caniga, Joseph Eckman, Robbie McLeod, Lily Moy, Alan Wilhelm, Janice Woodhouse, Jie Zhang-Hoover and Milenko Cicmil

Modulation of IL-17A and TL1A largely abrogates house dust mite-induced lung inflammation in murine model of allergic airway disease

Authors: C Hubeau, J Kubera, K Hammerman, J Wright J, M Denz, Y-T Juang and C Williams

Assessment of the time course of chronic inflammation in the murine house dust mite model

Authors: Stephen M Jordan, Robert Carrington, David Lanham, James Cartwright, Rachel A Armstrong and Kenneth G Meecham