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  1. Ischemia-reperfusion injury (IRI) is an antigen-independent, innate immune response to arterial occlusion and ischemia with subsequent paradoxical exacerbation after reperfusion. IRI remains a critical problem...

    Authors: Jordan R. Yaron, Hao Chen, Sriram Ambadapadi, Liqiang Zhang, Amanda M. Tafoya, Barbara H. Munk, Dara N. Wakefield, Jorge Fuentes, Bruno J. Marques, Krishna Harripersaud, Mee Yong Bartee, Jennifer A. Davids, Donghang Zheng, Kenneth Rand, Lisa Dixon, Richard W. Moyer…
    Citation: Journal of Inflammation 2019 16:12
    Content type: Short Report Published on:

  2. There is increasing evidence of a sustained state of systemic inflammation after pig-to-nonhuman primate (NHP) xenotransplantation (that has been termed systemic inflammation in xenograft recipients [SIXR]). I...

    Authors: Juan Li, Hidetaka Hara, Yi Wang, Charles Esmon, David K. C. Cooper and Hayato Iwase
    Citation: Journal of Inflammation 2019 16:10
    Content type: Review Published on:

  3. Correlations among the aqueous flare value (an indicator of inflammation), functional-morphologic parameters, and aqueous humor levels of growth factors/receptors and inflammatory factors/cytokines were invest...

    Authors: Asako Mashima, Hidetaka Noma, Kanako Yasuda, Hiroshi Goto and Masahiko Shimura
    Citation: Journal of Inflammation 2019 16:9
    Content type: Research Published on:

  4. Athrosclerosis is conceived as a chronic inflammatory status affecting cells from vascular walls. Different mechanisms and pathological features are evident at the onset of atherosclerotic changes via the enga...

    Authors: Mehdi Hassanpour, Reza Rahbarghazi, Mohammad Nouri, Nasser Aghamohammadzadeh, Nasser Safaei and Mahdi Ahmadi
    Citation: Journal of Inflammation 2019 16:8
    Content type: Review Published on:

  5. Macrophages engulf oxidized-LDL (oxLDL) leading to accumulation of cellular cholesterol and formation of foam cells, which is a hallmark of atherosclerosis. Moreover, recent studies showed that accumulation of...

    Authors: Cheng-Maw Ho, Shu-Li Ho, Yung-Ming Jeng, Yu-Sheng Lai, Ya-Hui Chen, Shao-Chun Lu, Hui-Ling Chen, Po-Yuan Chang, Rey-Heng Hu and Po-Huang Lee
    Citation: Journal of Inflammation 2019 16:7
    Content type: Research Published on:

  6. Cytokines are known to be key players in dry eye syndrome (DES) and Sjogren’s syndrome (SS) pathogenesis. In this study we compared single nucleotide polymorphism (SNP) variations in genes encoding cytokine le...

    Authors: Hadas Ben-Eli, Nir Gomel, Doron Jacob Aframian, Rania Abu-Seir, Riki Perlman, Eldad Ben-Chetrit, dror Mevorach, Geffen Kleinstern, Ora Paltiel and Abraham Solomon
    Citation: Journal of Inflammation 2019 16:6
    Content type: Research Published on:

  7. Inflammation is central to the pathogenesis of many diseases. Supplementation with selenium and coenzyme Q10 has been shown to reduce cardiovascular mortality, and increase cardiac function in elderly persons ...

    Authors: Urban Alehagen, Jan Alexander, Jan Aaseth and Anders Larsson
    Citation: Journal of Inflammation 2019 16:5
    Content type: Research Published on:

  8. Human airway smooth muscle cells (ASMCs) contribute to bronchial contraction and airway hyperresponsiveness in patients with bronchial asthma. They also generate cytokines, chemokines, and matricellular protei...

    Authors: Maiko Kadowaki, Hidenori Yamada, Koichi Sato, Hiroko Shigemi, Yukihiro Umeda, Miwa Morikawa, Yuko Waseda, Masaki Anzai, Yosuke Kamide, Haruka Aoki-Saito, Takeshi Hisada, Fumikazu Okajima and Tamotsu Ishizuka
    Citation: Journal of Inflammation 2019 16:4
    Content type: Research Published on:

  9. Sepsis is a systemic inflammatory response syndrome caused by severe infections. LDK378, a second-generation ALK inhibitor, exhibits a potential anti-inflammatory function against sepsis. Micro- and macro-circ...

    Authors: Weiwei Ge, Qiaohua Hu, Xiangshao Fang, Juanhua Liu, Jing Xu, Juntao Hu, Xuefen Liu, Qin Ling, Yue Wang, He Li, Ming Gao, Longyuan Jiang, Zhengfei Yang and Wanchun Tang
    Citation: Journal of Inflammation 2019 16:3
    Content type: Research Published on:

  10. In order to gain insight into the early effects drawn by JAK inhibitors on intra-joint JAK/STAT-dependent signaling, we sought synovial activation of STATs and their end-products, along with their modification...

    Authors: Sandra Pérez-Baos, Paula Gratal, Juan I. Barrasa, Ana Lamuedra, Olga Sánchez-Pernaute, Gabriel Herrero-Beaumont and Raquel Largo
    Citation: Journal of Inflammation 2019 16:2
    Content type: Research Published on:

  11. Acute lung injury (ALI) affects over 10% of patients hospitalised in critical care, with acute respiratory distress syndrome (ARDS) being the most severe form of ALI and having a mortality rate in the region o...

    Authors: Savino Spadaro, Mirae Park, Cecilia Turrini, Tanushree Tunstall, Ryan Thwaites, Tommaso Mauri, Riccardo Ragazzi, Paolo Ruggeri, Trevor T. Hansel, Gaetano Caramori and Carlo Alberto Volta
    Citation: Journal of Inflammation 2019 16:1
    Content type: Review Published on:

  13. Chondrocyte apoptosis is a central feature in the progression of osteoarthritis (OA), and would be triggered by sustained elevation of intracellular calcium ion (Ca2+), also known as a cellular second messenger. ...

    Authors: Songjiang Yin, Li Zhang, Liang Ding, Zhengquan Huang, Bo Xu, XiaoChen Li, Peimin Wang and Jun Mao
    Citation: Journal of Inflammation 2018 15:27
    Content type: Research Published on:

  14. Intravitreal ranibizumab injection (IRI) is effective for patients with exudative age-related macular degeneration (AMD) and decreases intraocular levels of vascular endothelial growth factor (VEGF), but VEGF ...

    Authors: Ryosuke Motohashi, Hidetaka Noma, Kanako Yasuda, Osamu Kotake, Hiroshi Goto and Masahiko Shimura
    Citation: Journal of Inflammation 2018 15:26
    Content type: Research Published on:

  15. The anti-inflammatory properties of the cannabinoid 2 receptor (CB2R) in injury and inflammatory diseases have been widely substantiated. Specifically, the anti-inflammatory effect of CB2R may be achieved by r...

    Authors: Yu Du, Peng Ren, Qi Wang, Shu-Kun Jiang, Miao Zhang, Jiao-Yong Li, Lin-Lin Wang and Da-Wei Guan
    Citation: Journal of Inflammation 2018 15:25
    Content type: Research Published on:

  16. Lutein is a dietary constituent known to inhibit inflammation; however, its effect on nociceptive neuron-associated hyperalgesia remains to be determined. The present study therefore investigated under in vivo...

    Authors: Yumiko Syoji, Ryota Kobayashi, Nako Miyamura, Tsukasa Hirohara, Yoshiko Kubota, Nobuo Uotsu, Kei Yui, Yoshihito Shimazu and Mamoru Takeda
    Citation: Journal of Inflammation 2018 15:24
    Content type: Research Published on:

  17. Inflammation is a natural part of the aging process. This process is referred to as inflammaging. Inflammaging has been associated with deleterious outcomes in the aging brain in diseases such as Alzheimer’s d...

    Authors: Nancy H. Mejias, Camila C. Martinez, Marisa E. Stephens and Juan Pablo de Rivero Vaccari
    Citation: Journal of Inflammation 2018 15:23
    Content type: Research Published on:

  19. High levels of serum lipopolysaccharide (LPS) were observed in sepsis patients with liver injury and high mortality. However, the role of liver in modulation LPS induced inflammatory injury was ill investigate...

    Authors: Haoshu Fang, Anding Liu, Xulin Chen, Wenhui Cheng, Olaf Dirsch and Uta Dahmen
    Citation: Journal of Inflammation 2018 15:21
    Content type: Research Published on:

  20. Zinc finger protein 580 (ZNF580) was reported to modulate angiogenesis, endothelial homeostasis and blood pressure control. ZNF580 regulated genes include VEGF-A and IL-8. However, it is unknown if ZNF580 coul...

    Authors: Philipp Stenzel, Kaj Nagorsen, Jonathan Bernd, Ulrike Leppert, Andreas Zakrzewicz and Janine Berkholz
    Citation: Journal of Inflammation 2018 15:20
    Content type: Research Published on:

  21. Degenerative lumbar spondylolisthesis (DLS) is a major cause of spinal canal stenosis and is often related to lower back pain. IL-20 is emerging as a potent angiogenic, chemotactic, and proinflammatory cytokin...

    Authors: Kuo-Yuan Huang, Yu-Hsiang Hsu, Wei-Yu Chen, Hui-Ling Tsai, Jing-Jou Yan, Jung-Der Wang, Wen-Lung Liu and Ruey-Mo Lin
    Citation: Journal of Inflammation 2018 15:19
    Content type: Research Published on:

  22. Inflammatory chemokine ligands (CCLs) play an important role in cardiovascular disease and allograft injury. CCLs may independently associate with diminished estimated glomerular filtration rate (eGFR) in stab...

    Authors: Ahmed Zahran, Ahmed Attia, Holly Mansell and Ahmed Shoker
    Citation: Journal of Inflammation 2018 15:18
    Content type: Research Published on:

  24. The aim of the study was to investigate the expression of the NEK7-NLRP3 inflammasome signaling pathway in the peripheral blood mononuclear cells (PBMCs) of patients with systemic lupus erythematosus (SLE), as...

    Authors: Zhen-Zhen Ma, Hong-Sheng Sun, Ji-Cai Lv, Lei Guo and Qing-Rui Yang
    Citation: Journal of Inflammation 2018 15:16
    Content type: Research Published on:

  25. T helper 17 (Th17) cells have proven to be crucial in the pathogenesis of neutrophils-dominant asthma. Hypoxia inducible factor-1α (HIF-1α) is involved in allergic responses in asthma. Our previous studies ind...

    Authors: Li Xu, Wen J. Sun, Ai J. Jia, Lu L. Qiu, Bing Xiao, Lin Mu, Jian M. Li, Xiu F. Zhang, Yan Wei, Cong Peng, Dong S. Zhang and Xu D. Xiang
    Citation: Journal of Inflammation 2018 15:15
    Content type: Research Published on:

  26. Articular cartilage diseases are considered a major health problem, and tissue engineering using human mesenchymal stem cells (MSCs) have been shown as a promising solution for cartilage tissue repair. Hesperi...

    Authors: Shipeng Xiao, Wenguang Liu, Jianqiang Bi, Shenghou Liu, Heng Zhao, Ningji Gong, Deguo Xing, Hongwei Gao and Mingzhi Gong
    Citation: Journal of Inflammation 2018 15:14
    Content type: Research Published on:

  27. The CARD family plays an important role in innate immune response by the activation of NF-κB. The aim of this study was to determine the gene expression and to enumerate the protein-expressing cells of some me...

    Authors: Jesús K. Yamamoto-Furusho, Gabriela Fonseca-Camarillo, Janette Furuzawa-Carballeda, Andrea Sarmiento-Aguilar, Rafael Barreto-Zuñiga, Braulio Martínez-Benitez and Montserrat A. Lara-Velazquez
    Citation: Journal of Inflammation 2018 15:13
    Content type: Research Published on:

  28. Breakdown of the alveolo-capillary wall is pathognomonic for Acute Lung Injury (ALI). Angiopoietins, vascular-specific growth factors, are linked to endothelial barrier dysfunction, and elevated Angiopoietin-2...

    Authors: Heidi Ehrentraut, Christina Weisheit, Marcel Scheck, Stilla Frede and Tobias Hilbert
    Citation: Journal of Inflammation 2018 15:12
    Content type: Research Published on:

  29. Established animal trauma models are limited in recapitulating the pathophysiology of human traumatic injury. Herein, we characterize the physiologic insult and inflammatory response in two clinically relevant...

    Authors: Diego A. Vicente, Matthew J. Bradley, Benjamin Bograd, Crystal Leonhardt, Eric A. Elster and Thomas A. Davis
    Citation: Journal of Inflammation 2018 15:11
    Content type: Research Published on:

  30. Endothelial progenitor cell (EPC) numbers are increased in septic patients and correlate with survival. In this study, we investigated, whether surface expression of chemokine receptors and other receptors imp...

    Authors: Christian Patry, Daniela Stamm, Christian Betzen, Burkhard Tönshoff, Benito A. Yard, Grietje Ch. Beck and Neysan Rafat
    Citation: Journal of Inflammation 2018 15:10
    Content type: Research Published on:

  32. Sepsis is one of the leading causes of death among hospitalized patients. At the onset of this condition, there is an over-production of pro-inflammatory mediators that contribute to organ failure and death. T...

    Authors: K. L. C. da Silva, A. P. Camacho, F. C. Mittestainer, B. M. Carvalho, A. Santos, D. Guadagnini, A. G. Oliveira and M. J. A. Saad
    Citation: Journal of Inflammation 2018 15:8
    Content type: Research Published on:

  33. Inflammatory bowel disease (IBD) is one of the chronic gastrointestinal diseases with increasing risk of colon cancer development in the future. Apoptosis and inflammation play an important role in the etiolog...

    Authors: Chunyan Lou and Yanyang Li
    Citation: Journal of Inflammation 2018 15:7
    Content type: Research Published on:

  34. Upon publication of the original article [1] it was highlighted by the authors that the first affiliation of author Haiyan Yin was incorrectly cited in duplicate as “Department of Neurology, Affiliated Hospita...

    Authors: Haiyan Yin, Shuwen Song and Xudong Pan
    Citation: Journal of Inflammation 2018 15:6
    Content type: Correction Published on:

    The original article was published in Journal of Inflammation 2017 14:17

  35. Melanoma is one of the most common types of skin malignancies. Since current therapies are suboptimal, considerable interest has focused on novel natural-based treatments. Toll-like receptors (TLRs) play an im...

    Authors: Mehdi Taghavi, Esmaeil Mortaz, Alireza Khosravi, Ghasem Vahedi, Gert Folkerts, Mohammad Varahram, Mehdi Kazempour-Dizaji, Johan Garssen and Ian M. Adcock
    Citation: Journal of Inflammation 2018 15:5
    Content type: Research Published on:

  36. Impairment of the blood-brain barrier (BBB) in severe acute pancreatitis (SAP) could result in life-threatening pancreatic encephalopathy. Interleukin-10 (IL-10) is a classical cytokine that is well-known for ...

    Authors: Ronggui Lin, Fei Chen, Shi Wen, Tianhong Teng, Yu Pan and Heguang Huang
    Citation: Journal of Inflammation 2018 15:4
    Content type: Research Published on:

  37. Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection, and is primarily characterized by an uncontrolled systemic inflammatory response. In the present study, we deve...

    Authors: Wen-Feng Fang, Yu-Mu Chen, Chiung-Yu Lin, Hui-Lin Huang, Hua Yeh, Ya-Ting Chang, Kuo-Tung Huang and Meng-Chih Lin
    Citation: Journal of Inflammation 2018 15:3
    Content type: Research Published on:

  38. In vivo studies have shown grape seed-derived polyphenols (GSP) to benefit in recovery from muscle injury by modulation of neutrophil infiltration into damaged tissue, thereby reducing secondary damage, as wel...

    Authors: T. Smith, L. Engelbrecht and C. Smith
    Citation: Journal of Inflammation 2018 15:2
    Content type: Research Published on:

  39. Gastrointestinal acute graft-versus-host disease (GI aGVHD) is a lethal complication following allogeneic hematopoietic stem cell transplantation (HSCT). However, it is still very difficult to make a diagnosis...

    Authors: Na Wang, Xiaoyi Qin, Yigeng Cao, Bin Liang, Kang Yu and Haige Ye
    Citation: Journal of Inflammation 2018 15:1
    Content type: Research Published on:

  41. An unmet need remains for safe and effective treatments to induce and maintain remission in inflammatory bowel disease (IBD) patients. The Janus kinase (JAK) inhibitor, tofacitinib, has demonstrated robust eff...

    Authors: David T. Beattie, M. Teresa Pulido-Rios, Fei Shen, Melissa Ho, Eva Situ, Pam R. Tsuruda, Patrick Brassil, Melanie Kleinschek and Sharath Hegde
    Citation: Journal of Inflammation 2017 14:28
    Content type: Research Published on:

  42. Septic shock remains a leading cause of death worldwide. Hyperbaric oxygen treatment (HBO2) has been shown to alter the inflammatory response during sepsis and to reduce mortality. A therapeutic window of HBO2 tr...

    Authors: Nina Falcon Bærnthsen, Marco Bo Hansen, Anna Mygind Wahl, Ulf Simonsen and Ole Hyldegaard
    Citation: Journal of Inflammation 2017 14:27
    Content type: Research Published on:

  43. Primary Sjögren’s syndrome is an autoimmune disease characterized by dry eye and dry mouth. We systematically reviewed all the randomized controlled clinical trials published in the last 15 years that included...

    Authors: Kendrick Co Shih, Christie Nicole Lun, Vishal Jhanji, Bernard Yu-Hor Thong and Louis Tong
    Citation: Journal of Inflammation 2017 14:26
    Content type: Review Published on:

  44. Hyperoside (Hyp) is a flavonoid glycoside compound that has been demonstrated to have anti-inflammatory, anti-apoptotic and antioxidant effects. However, the impact of Hyp on inflammatory bowel disease (IBD) h...

    Authors: Lei Yang, Lei Shen, Yue Li, Yanxia Li, Shijie Yu and Shanshan Wang
    Citation: Journal of Inflammation 2017 14:25
    Content type: Research Published on:

  45. Inflammatory cytokines have been demonstrated to be involved in developing insulin resistance and type-2 diabetes (T2D). Natural antibodies in the circulation have protective effects on common diseases in huma...

    Authors: Weiyi Cai, Cailing Qiu, Hongyu Zhang, Xiangyun Chen, Xuan Zhang, Qingyong Meng and Jun Wei
    Citation: Journal of Inflammation 2017 14:24
    Content type: Research Published on:

  46. Multi-organ failure (MOF) following trauma remains a significant cause of morbidity and mortality related to a poorly understood abnormal inflammatory response. We characterized the inflammatory response in a ...

    Authors: Matthew J. Bradley, Diego A. Vicente, Benjamin A. Bograd, Erin M. Sanders, Crystal L. Leonhardt, Eric A. Elster and Thomas A. Davis
    Citation: Journal of Inflammation 2017 14:23
    Content type: Research Published on:

  47. This study was aimed to evaluate the effect of LPS in glucocorticoid receptor (GR) isoforms expression on different cell lines and PBMC from healthy donors in vitro and glucocorticoid sensitivity of PBMC in vi...

    Authors: Maria Luisa Molina, Julia Guerrero, John A. Cidlowski, Héctor Gatica and Annelise Goecke
    Citation: Journal of Inflammation 2017 14:22
    Content type: Research Published on:

  48. In this study, a competitive hepcidin ELISA assay was evaluated for its ability to differentiate between iron deficiency anaemia with concurrent inflammation and anaemia of inflammation in elderly patients, us...

    Authors: Torbjörn Karlsson
    Citation: Journal of Inflammation 2017 14:21
    Content type: Short Report Published on:

  49. The role of bronchiolar epithelial cells in the pathogenesis of pulmonary fibrosis has not been clarified. We previously demonstrated DNA damage in murine bronchioles in the early stages of bleomycin-induced p...

    Authors: Tetsuya Yokoyama, Toyoshi Yanagihara, Kunihiro Suzuki, Naoki Hamada, Kazuya Tsubouchi, Saiko Ogata-Suetsugu, Hironori Mikumo, Chika Ikeda-Harada, Takashige Maeyama, Kazuyoshi Kuwano and Yoichi Nakanishi
    Citation: Journal of Inflammation 2017 14:20
    Content type: Research Published on:

  50. Sepsis is a life-threatening condition and obesity is related to the clinical outcome. The underlying reasons are incompletely understood, but the adipocyte derived hormones leptin and adiponectin may be invol...

    Authors: Sofie Jacobsson, Peter Larsson, Göran Johansson, Margareta Norberg, Göran Wadell, Göran Hallmans, Ola Winsö and Stefan Söderberg
    Citation: Journal of Inflammation 2017 14:19
    Content type: Research Published on:

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Journal of Inflammation

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