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  1. Content type: Research

    We aimed to investigate peripheral blood eosinophil chemotaxis, generation of spontaneous reactive oxygen species (ROS), and apoptosis in patients with allergic asthma after bronchial allergen challenge.

    Authors: Simona Lavinskiene, Kestutis Malakauskas, Jolanta Jeroch, Deimante Hoppenot and Raimundas Sakalauskas

    Citation: Journal of Inflammation 2015 12:25

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  2. Content type: Short Report

    Chronic Kidney Disease (CKD) and inflammation are risk factors for atherosclerotic vascular disease (ASVD). In inflammatory conditions, Nuclear Factor-κB (NF-κB) is frequently activated and it has been detecte...

    Authors: Miguel Hueso, Joan Torras, Marta Carrera, August Vidal, Estanis Navarro and Josep Grinyó

    Citation: Journal of Inflammation 2015 12:26

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  3. Content type: Research

    Cartilage damage is a crucial step in rheumatoid arthritis (RA) disease progress while its molecular mechanisms are not fully understood. Here we investigated the expression of hedgehog (Hh) signal pathway in ...

    Authors: Rong Li, Li Cai, Cheng-mu Hu, Ting-ni Wu and Jun Li

    Citation: Journal of Inflammation 2015 12:24

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  4. Content type: Research

    To explore the immunological mechanisms underlying the effect of chronic intermittent hypobaric hypoxia (CIHH) pretreatment on collagen-induced arthritis (CIA) in rat.

    Authors: Min Shi, Fang Cui, Ai-Jing Liu, Hui-Jie Ma, Ming Cheng, Shu-Xia Song, Fang Yuan, De-Pei Li and Yi Zhang

    Citation: Journal of Inflammation 2015 12:23

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  5. Content type: Research

    Apolipoprotein A-IV (apoA-IV) is a protein mainly synthesized by enterocytes in the intestine. Its gene expression is suppressed during fasting and stimulated during active fat absorption. Chronic feeding of a...

    Authors: Xiaoming Li, Min Xu, Min Liu, Yong Ji and Zongfang Li

    Citation: Journal of Inflammation 2015 12:22

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  6. Content type: Research

    Sarcoidosis is a systemic disease of unknown etiology characterized histologically by the observation of non-caseating granulomas and several immunological abnormalities. Sarcoidosis is a multi-organ disorder ...

    Authors: Esmaeil Mortaz, Hale Abdoli Sereshki, Atefeh Abedini, Arda Kiani, Mehdi Mirsaeidi, Dina Soroush, Johan Garssen, Aliakbar Velayati, Frank A Redegeld and Ian M Adcock

    Citation: Journal of Inflammation 2015 12:21

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  7. Content type: Research

    Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation and progressive decline in pulmonary function. Neutrophil-to-lymphocyte ratio (NLR), YKL-40 and calprotectin are biomarkers...

    Authors: Allan Klitgaard Sørensen, Dennis Back Holmgaard, Lone Hagens Mygind, Julia Johansen and Court Pedersen

    Citation: Journal of Inflammation 2015 12:20

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  8. Content type: Research

    Inflammatory bowel disease is an immunologically mediated disease. Notably, it is less common in countries where there is a greater risk of exposure to helminths. In our study, we examined the modulatory effec...

    Authors: Imene Soufli, Ryma Toumi, Hayet Rafa, Manel Amri, Moussa Labsi, Lila Khelifi, Ferdinando Nicoletti and Chafia Touil-Boukoffa

    Citation: Journal of Inflammation 2015 12:19

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  9. Content type: Research

    In inflammatory joint disease, such as osteoarthritis or arthritis, there is an increased level of pro-inflammatory cytokines, such as interleukin-1β. These cytokines stimulate the expression and release of ma...

    Authors: Catherine Baugé, Eva Lhuissier, Nicolas Girard, Céline Quesnelle, Gérard Ewert and Karim Boumediene

    Citation: Journal of Inflammation 2015 12:17

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  10. Content type: Research

    Human parainfluenza virus type 3 (HPIV3), while infecting lower airway epithelial cells induces pneumonia and bronchiolitis in infants and children, and may lead to asthma exacerbations in children and adults....

    Authors: Anna Lewandowska-Polak, Małgorzata Brauncajs, Edyta Paradowska, Marzanna Jarzębska, Marcin Kurowski, Sylwia Moskwa, Zbigniew J Leśnikowski and Marek L Kowalski

    Citation: Journal of Inflammation 2015 12:16

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  11. Content type: Research

    Atherosclerosis, the underlying cause of heart attack and strokes, is a progresive dyslipidemic and inflammatory disease where monocyte-derived macrophage cells play a pivotal role. Although most of the mechan...

    Authors: Monica de Gaetano, Kawthar Alghamdi, Simone Marcone and Orina Belton

    Citation: Journal of Inflammation 2015 12:15

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  12. Content type: Research

    Nuclear receptor 4A2 (NR4A2) is an orphan nuclear receptor and constitutively active transcription factor expressed at elevated levels in inflamed joint tissues from patients with arthritis. Inflammatory media...

    Authors: Joseph M McCoy, Dana E Walkenhorst, Keegan S McCauley, Hiba Elaasar, Jordan R Everett and Kimberlee S Mix

    Citation: Journal of Inflammation 2015 12:13

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  13. Content type: Review

    Ionizing radiation (IR) activates both pro-and anti-proliferative signal pathways producing an imbalance in cell fate decision. IR is able to regulate several genes and factors involved in cell-cycle progressi...

    Authors: Federica Maria Di Maggio, Luigi Minafra, Giusi Irma Forte, Francesco Paolo Cammarata, Domenico Lio, Cristina Messa, Maria Carla Gilardi and Valentina Bravatà

    Citation: Journal of Inflammation 2015 12:14

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  14. Content type: Research

    The oxidative stress response is a cellular defense mechanism that protects cells from oxidative damage and cancer development. The exact molecular mechanism by which reactive oxygen species (ROS) contribute t...

    Authors: Bilge Debelec-Butuner, Nursah Ertunc and Kemal Sami Korkmaz

    Citation: Journal of Inflammation 2015 12:12

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  15. Content type: Research

    Delayed M1 toward M2 macrophage phenotype transition is considered one of the major causes for the impaired healing after myocardial infarction (MI). While searching for molecules that modulate M1 and M2 macro...

    Authors: Long-Shu Zhou, Guo-Long Zhao, Qiang Liu, Shu-Cai Jiang, Yun Wang and Dong-Mei Zhang

    Citation: Journal of Inflammation 2015 12:11

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  16. Content type: Research

    Genetic studies have pointed out that CD226 variants, encoding DNAM-1, could be associated with susceptibility to rheumatoid arthritis. Therefore, we aimed to determine the influence of DNAM-1 on the development ...

    Authors: Muriel Elhai, Gilles Chiocchia, Carmen Marchiol, Franck Lager, Gilles Renault, Marco Colonna, Guenter Bernhardt, Yannick Allanore and Jérôme Avouac

    Citation: Journal of Inflammation 2015 12:9

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  17. Content type: Research

    Adipose cells responsible for fat storage are the targets of reactive oxygen species (ROS) like H2O2 and pro-inflammatory agents including TNFα and LPS. Such mediators contribute to oxidative stress and alter inf...

    Authors: Méry Marimoutou, Fanny Le Sage, Jacqueline Smadja, Christian Lefebvre d’Hellencourt, Marie-Paule Gonthier and Christine Robert-Da Silva

    Citation: Journal of Inflammation 2015 12:10

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  18. Content type: Research

    Obesity is regarded as a risk factor for cardiovascular disease. Bone morphogenetic protein 4 (BMP4) is a proinflammatory and profibrotic factor, and the reduced expression of this molecule in obese mice seems...

    Authors: Ting Wu, Qiu-Yang Ling, Cheng Zhong, Tian-Xiao Wang, Lu-Lu Wang, Xiao-Ying Wang, Zhao-Liang Su and Gang-Jun Zong

    Citation: Journal of Inflammation 2015 12:8

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  19. Content type: Research

    Milk-derived bioactive peptides retain many biological properties and have therapeutic effects in cardiovascular disorders such as atherosclerosis. Under inflammatory conditions the expression of endothelial c...

    Authors: Simone Marcone, Karen Haughton, Paul J Simpson, Orina Belton and Desmond J Fitzgerald

    Citation: Journal of Inflammation 2015 12:1

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  20. Content type: Research

    In sub-Saharan Africa poly-parasite infections are frequently observed in children, and with poly-parasitism modulating immune mechanisms, mediated by cytokines and chemokines, are required to prevent overwhel...

    Authors: Jana Hegewald, Richard G Gantin, Christian J Lechner, Xiangsheng Huang, Abram Agosssou, Yvon F Agbeko, Peter T Soboslay and Carsten Köhler

    Citation: Journal of Inflammation 2015 12:5

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  21. Content type: Research

    Adenosine is a potent endogenous anti-inflammatory and immunoregulatory molecule. Despite its promise, adenosine’s extremely short half-life in blood limits its clinical application. Here, we examined adenosin...

    Authors: Keizo Kohno, Emiko Ohashi, Osamu Sano, Hajime Kusano, Toshio Kunikata, Norie Arai, Toshiharu Hanaya, Toshio Kawata, Tomoyuki Nishimoto and Shigeharu Fukuda

    Citation: Journal of Inflammation 2015 12:2

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  22. Content type: Research

    Plants from the genus Ocimum are used as folk medicine for treating various diseases including inflammatory and immune-related diseases. Numerous reports have suggested plant extracts and their constituents as po...

    Authors: Petrina Kapewangolo, Justin J Omolo, Ronel Bruwer, Pascaline Fonteh and Debra Meyer

    Citation: Journal of Inflammation 2015 12:4

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  23. Content type: Research

    To explore the upstream signal transduction mechanisms responsible for the imbalanced expression of glucocorticoid receptor (GR) isoforms in chronic rhinosinusitis (CRS) mucosa.

    Authors: Zhenlin Wang, Peng Li, Qiuhang Zhang, Haili Lv, Junqi Liu and Jinyuan Si

    Citation: Journal of Inflammation 2015 12:3

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  24. Content type: Research

    Red palm oil (RPO) and rooibos have been shown to exhibit cardioprotective properties. RPO is rich in essential fatty acids and fat soluble antioxidants while rooibos contains polyphenolic compounds with a uni...

    Authors: Emma Katengua-Thamahane, Jeanine L Marnewick, Olawale R Ajuwon, Novel N Chegou, Gergő Szűcs, Péter Ferdinandy, Tamás Csont, Csaba Csonka and Jacques Van Rooyen

    Citation: Journal of Inflammation 2014 11:41

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  25. Content type: Research

    It has recently been found that both nuclear epithelial-expressed histone deacetylases Hdac1 and Hdac2 are important to insure intestinal homeostasis and control the mucosal inflammatory response in vivo. In addi...

    Authors: Alexis Gonneaud, Julie Moore Gagné, Naomie Turgeon and Claude Asselin

    Citation: Journal of Inflammation 2014 11:43

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  26. Content type: Research

    Vocal fold fibroblast’s (VFF) strategic location in the lamina propria and their ability to respond to external stimuli by producing inflammatory molecules suggest their possible direct involvement in innate i...

    Authors: Suzanne N King, Craig M Berchtold and Susan L Thibeault

    Citation: Journal of Inflammation 2014 11:42

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  27. Content type: Research

    In human gingival fibroblasts (HGFs), TLR4 recognises Pathogen-associated molecular patterns (PAMPs), such as LPS, and subsequently activates downstream signals that lead to the production of pro-inflammatory ...

    Authors: Yu-feng Xie, Rong Shu, Shao-yun Jiang, Zhong-chen Song, Qiu-man Guo, Jia-chen Dong and Zhi-kai Lin

    Citation: Journal of Inflammation 2014 11:38

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  28. Content type: Research

    Obesity is the world’s most important public health problem. Adipose tissue contributes significantly to increase pro-inflammatory mediators whose cascade begins with the union of TLR4 to its microbial ligands...

    Authors: Cesar Octavio De Loera-Rodriguez, Vidal Delgado-Rizo, Anabell Alvarado-Navarro, Juan Manuel Agraz-Cibrian, Jorge E Segura-Ortega and Mary Fafutis-Morris

    Citation: Journal of Inflammation 2014 11:39

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  29. Content type: Research

    Hyperglycemia exacerbates brain damage caused by cerebral ischemia. Neuroinflammation may play a role in mediating such enhanced damage. The objectives of this study were to examine the mRNA and protein levels...

    Authors: Li Jing, Jian-Gang Wang, Jian-Zhong Zhang, Cai-Xia Cao, Yue Chang, Jian-Da Dong, Feng-Ying Guo and P Andy Li

    Citation: Journal of Inflammation 2014 11:35

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  30. Content type: Research

    The response of the joint to anterior cruciate ligament (ACL) injury has not been fully characterized. In particular, the characterization of both catabolic factors, including interleukin-6 (IL-6), interleukin...

    Authors: Carla M Haslauer, Benedikt L Proffen, Victor M Johnson, Adele Hill and Martha M Murray

    Citation: Journal of Inflammation 2014 11:34

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  31. Content type: Research

    The aim of this study were to investigate whether selenium treatment attenuates lipid peroxidation and downregulates the NF-κB pathway in small intestinal mucosa and to examine whether the effect of selenium i...

    Authors: Yongsoo Kim, Dong Chil Kim, Eui-Sic Cho, Seung-O Ko, Woon Yong Kwon, Gil Joon Suh and Hyo-Keun Shin

    Citation: Journal of Inflammation 2014 11:36

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  32. Content type: Research

    Aspirin is one of the most widely used non-steroidal anti-inflammatory drugs (NSAIDs). It is also a commonly used anti-platelet drug, which inhibits the formation of the platelet activator, thromboxane A2 (TxA2) ...

    Authors: Benjamin H Maskrey, Gordon F Rushworth, Matthew H Law, Andrew T Treweeke, Jun Wei, Stephen J Leslie, Ian L Megson and Phillip D Whitfield

    Citation: Journal of Inflammation 2014 11:33

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  33. Content type: Research

    Cardiopulmonary bypass (CPB) is an immuno-reactive state where neutrophils are activated and accumulate in different tissues. Edema and tissue necrosis are the most common sequelae observed, predominantly in t...

    Authors: Mary Elizabeth Wilcox, Emmanuel Charbonney, Pablo Perez d’Empaire, Abhijit Duggal, Ruxandra Pinto, Ashkan Javid, Claudia Dos Santos, Gordon David Rubenfeld, Susan Sutherland, Wayne Conrad Liles and Michael Glogauer

    Citation: Journal of Inflammation 2014 11:32

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  34. Content type: Research

    Inflammation plays an important role in the pathogenesis of atherosclerosis. The link between rheumatoid arthritis (RA) and an increased risk of cardiovascular disease and mortality is well established; howeve...

    Authors: Fenling Fan, Abby Galvin, Lu Fang, David Andrew White, Xiao-lei Moore, Miles Sparrow, Flavia Cicuttini and Anthony Michael Dart

    Citation: Journal of Inflammation 2014 11:29

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  35. Content type: Research

    Hemorrhagic shock and resuscitation (HS/R) can induce multiple organ failure which is associated with high mortality. The lung is an organ commonly affected by the HS/R. Acute lung injury is a major cause of d...

    Authors: Raymond LC Kao, Xuemei Xu, Anargyros Xenocostas, Neil Parry, Tina Mele, Claudio M Martin and Tao Rui

    Citation: Journal of Inflammation 2014 11:30

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  36. Content type: Research

    Human in vivo models of systemic inflammation are used to study the physiological mechanisms of inflammation and the effect of drugs and nutrition on the immune response. Although in vivo lipopolysaccharide (LPS)...

    Authors: Marlous R Dillingh, Eveline P van Poelgeest, Karen E Malone, Elles M Kemper, Erik S G Stroes, Matthijs Moerland and Jacobus Burggraaf

    Citation: Journal of Inflammation 2014 11:28

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  37. Content type: Research

    This study tested the hypothesis that rosuvastatin reduces thrombus burden through inhibiting inflammation and suppressing reactive oxygen species (ROS) generation in an inferior vena cava stenosis (IVCST)-induce...

    Authors: Kun-Chen Lin, Hung-I Lu, Yung-Lung Chen, Tzu-Hsien Tsai, Li-Teh Chang, Steve Leu, Shu-Yuan Hsu, Cheuk-Kwan Sun, Han-Tan Chai, Hsueh-Wen Chang, Chia-Lo Chang, Hong-Hwa Chen and Hon-Kan Yip

    Citation: Journal of Inflammation 2014 11:27

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  38. Content type: Research

    Human gliomas pose significant morbidity and mortality to those afflicted by them, and currently there are no curative treatment modalities available for these highly invasive tumours.

    Authors: Mastura Monif, Terence J O’Brien, Kate J Drummond, Christopher A Reid, Simon V Liubinas and David A Williams

    Citation: Journal of Inflammation 2014 11:25

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  39. Content type: Research

    Cardiopulmonary bypass (CPB) is a commonly used technique in cardiac surgery. CPB is however associated with a strong induction of systemic inflammatory response syndrome (SIRS) which in conjunction with ische...

    Authors: Melanie Engels, Esra Bilgic, Antonio Pinto, Edwin Vasquez, Lena Wollschläger, Holger Steinbrenner, Kristine Kellermann, Payam Akhyari, Artur Lichtenberg and Udo Boeken

    Citation: Journal of Inflammation 2014 11:26

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  40. Content type: Review

    Activation of nuclear factor-kappa B (NF- κ B) as a mechanism of host defense against infection and stress is the central mediator of inflammatory responses. A normal (acute) inflammatory response is activated on...

    Authors: Srabani Pal, Ashish Bhattacharjee, Asif Ali, Narayan C Mandal, Subhash C Mandal and Mahadeb Pal

    Citation: Journal of Inflammation 2014 11:23

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  41. Content type: Research

    Asthma is a chronic inflammatory disorder of the airways with the proven role of Th2 cells in its pathogenesis. The role and characteristic of different subsets of CD4+ cells is much less known.

    Authors: Adam Barczyk, Wladyslaw Pierzchala, Gaetano Caramori, Ryszard Wiaderkiewicz, Marcin Kaminski, Peter J Barnes and Ian M Adcock

    Citation: Journal of Inflammation 2014 11:22

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  42. Content type: Research

    Tuberculosis (TB) is a rare but known cause of acute respiratory distress syndrome (ARDS). The role of inflammatory cytokines in the progression of ARDS in TB patients is unknown.

    Authors: Seyed Mohamad Reza Hashemian, Esmaeil Mortaz, Payam Tabarsi, Hamidreza Jamaati, Zohreh Maghsoomi, Adnan Khosravi, Johan Garssen, Mohamad Reza Masjedi, Ali Akbar Velayati, Gert Folkerts, Peter J Barnes and Ian M Adcock

    Citation: Journal of Inflammation 2014 11:21

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  43. Content type: Research

    Toll-like receptor (TLR) activation is hypothesized to contribute to inflammatory eye disease including uveitis, yet the distribution pattern of TLRs in human uveal tissues remains poorly described. The purpos...

    Authors: Kelly Mai, Jeanie JY Chui, Nick Di Girolamo, Peter J McCluskey and Denis Wakefield

    Citation: Journal of Inflammation 2014 11:20

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  44. Content type: Research

    Heat shock protein 70 (Hsp70) is an intracellular chaperone protein with regulatory and cytoprotective functions. Hsp70 can also be found in the extracellular milieu, as a result of active secretion or passive...

    Authors: Eduardo Ferat-Osorio, Aldair Sánchez-Anaya, Mireille Gutiérrez-Mendoza, Ilka Boscó-Gárate, Isabel Wong-Baeza, Rodolfo Pastelin-Palacios, Gustavo Pedraza-Alva, Laura C Bonifaz, Pedro Cortés-Reynosa, Eduardo Pérez-Salazar, Lourdes Arriaga-Pizano, Constantino López-Macías, Yvonne Rosenstein and Armando Isibasi

    Citation: Journal of Inflammation 2014 11:19

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Affiliated with the British Inflammation Research Association (BIRAs).

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