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  1. Rheumatoid arthritis is a chronic inflammatory debilitating disease triggered by a complex interaction involving genetic and environmental factors. Active smoking and occupational exposures such as silica incr...

    Authors: Mickael Essouma and Jean Jacques N. Noubiap

    Citation: Journal of Inflammation 2015 12:48

    Content type: Review

    Published on:

  2. The aim of the present study is to investigate the effects of two structurally divergent coumarins, calipteryxin (1) and (3’S,4’S)-3’,4’-disenecioyloxy-3’,4’-dihydroseselin (2) from Seseli recinosum, in lipopolys...

    Authors: Salman Khan, Omer Shehzad, Mao-Sheng Cheng, Rui-Juan Li and Yeong Shik Kim

    Citation: Journal of Inflammation 2015 12:47

    Content type: Research

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  3. This study was designed to evaluate the protective effects of thalidomide on paraquat (PQ)-induced lung injuries in a rat model and to explore the underlying mechanisms.

    Authors: Dan Li, Xiao-Wei Zhang, Xing-Quan Jiang, Yong-Jie Yin, Zhe Fan, Cheng-Bo Sun, Xing-Hai Chen, Yan-Hui Li and Ke-Xiang Liu

    Citation: Journal of Inflammation 2015 12:46

    Content type: Research

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  4. Several organs in the body comprise cells coupled into networks. These cells have in common that they are excitable but do not express action potentials. Furthermore, they are equipped with Ca2+ signaling systems...

    Authors: Elisabeth Hansson and Eva Skiöldebrand

    Citation: Journal of Inflammation 2015 12:44

    Content type: Review

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  5. Status epilepticus (SE) can cause neuronal cell death and impaired behavioral function. Acute exposure to potent acetylcholinesterase inhibitors such as soman (GD) can cause prolonged SE activity, micro-hemorr...

    Authors: Erik A. Johnson, Michelle A. Guignet, Thuy L. Dao, Tracey A. Hamilton and Robert K. Kan

    Citation: Journal of Inflammation 2015 12:43

    Content type: Research

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  6. The tristetraprolin (TTP) family of mRNA-binding proteins contains three major members, Ttp, Zfp36l1, and Zfp36l2. Ttp down-regulates the stability of AU-rich element–containing mRNAs and functions as an anti-...

    Authors: Kuan-Ting Wang, Hsin-Hui Wang, Yan-Yun Wu, Yu-Lun Su, Pei-Yu Chiang, Nien-Yi Lin, Shun-Chang Wang, Geen-Dong Chang and Ching-Jin Chang

    Citation: Journal of Inflammation 2015 12:42

    Content type: Research

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  7. Nur77, an orphan member of the nuclear receptor superfamily, has been implicated in the regulation of inflammation. However, the in vivo function of Nur77 remains largely unexplored. In the current study, we inv...

    Authors: Xiu-Ming Li, Xing-Xing Lu, Qian Xu, Jing-Ru Wang, Shen Zhang, Peng-Da Guo, Jian-Ming Li and Hua Wu

    Citation: Journal of Inflammation 2015 12:40

    Content type: Short Report

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  8. Immunomodulatory effects in humans of Δ9−Tetrahydrocannabinol (THC), the psychoactive component of marijuana are controversial. Tissue factor (TF), the activator of the extrinsic coagulation cascade, is increased...

    Authors: Julie C. Williams, Thomas W. Klein, Bruce A. Goldberger, John W. Sleasman, Nigel Mackman and Maureen M. Goodenow

    Citation: Journal of Inflammation 2015 12:39

    Content type: Short Report

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  9. Systemic Lupus Erythematosus (SLE) is an auto-immune disease whose complex pathogenesis remains unraveled. Here we aim to explore the inflammatory ability of SLE patients’ sera upon peripheral blood (PB) monoc...

    Authors: Tiago Carvalheiro, Diane Gomes, Ligia A. Pinto, Luis Inês, Ana Lopes, Ana Henriques, Susana Pedreiro, António Martinho, Hélder Trindade, Howard A. Young, José António Pereira da Silva and Artur Paiva

    Citation: Journal of Inflammation 2015 12:38

    Content type: Research

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  10. There is mounting evidence to support the role of inflammation in benign prostate hyperplasia (BPH), and a recent study reported expression of inflammasome derived cytokine IL-18 in prostate biopsy of BPH pati...

    Authors: Mahendra Kashyap, Subrata Pore, Zhou Wang, Jeffrey Gingrich, Naoki Yoshimura and Pradeep Tyagi

    Citation: Journal of Inflammation 2015 12:37

    Content type: Research

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  11. The nuclear receptors PPAR-γ and LXRs regulate macrophage lipid metabolism and macrophage mediated inflammation. We examined the influence of these molecules on macrophage alternative activation, with particul...

    Authors: Gaetano Zizzo and Philip L Cohen

    Citation: Journal of Inflammation 2015 12:36

    Content type: Research

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  12. Acute ulcerative colitis is an inflammation-driven condition of the bowel. It hampers the general homeostasis of gut, resulting in decreased mucus production and epithelial cell renewal. Adiponectin (APN), an ...

    Authors: Kamaljeet Kaur, Arpit Saxena, Bianca Larsen, Samantha Truman, Nathan Biyani, Emma Fletcher, Manjeshwar Shrinath Baliga, Venkatesh Ponemone, Shweta Hegde, Anindya Chanda and Raja Fayad

    Citation: Journal of Inflammation 2015 12:35

    Content type: Research

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  13. This study was designed to investigate the effect of glucose 6-phosphate dehydrogenase (G6PD) deficiency on pro-inflammatory cytokine secretion using a palmitate-induced inflammation HepG2 in vitro model. The ...

    Authors: Hung-Chi Yang, Mei-Ling Cheng, Yi-Syuan Hua, Yi-Hsuan Wu, Hsin-Ru Lin, Hui-Ya Liu, Hung-Yao Ho and Daniel Tsun-Yee Chiu

    Citation: Journal of Inflammation 2015 12:34

    Content type: Research

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  14. Studies suggest that inflammation is a key factor in the pathogenesis of diabetes mellitus. Pro-inflammatory cytokines, such as IL-6 and TNF-alpha, are produced by adipose tissue in large quantities, in obese ...

    Authors: Francisca Adilfa de Oliveira Garcia, Jéssica Farias Rebouças, Teresa Queiroz Balbino, Teresinha Gonçalves da Silva, Carlson Hélder Reis de Carvalho-Júnior, Gilberto Santos Cerqueira, Gerly Anne de Castro Brito and Glauce Socorro de Barros Viana

    Citation: Journal of Inflammation 2015 12:33

    Content type: Research

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  15. MMP-9 is crucial for a normal immune response, but excessive release of this enzyme leads to severe tissue damage. Listeria monocytogenes (LM) is an opportunistic food-borne pathogen causing listerosis, meningiti...

    Authors: Puthiyaveetil Kochumon Shihab, Areej Al-Roub, Moneera Al-Ghanim, Anfal Al-Mass, Kazem Behbehani and Rasheed Ahmad

    Citation: Journal of Inflammation 2015 12:32

    Content type: Research

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  16. Monocyte chemoattractant protein-1 (MCP-1) is a major chemokine that recruits monocyte/macrophage to the site of tissue injury and plays a critical role in microvascular complications of diabetes. However, the...

    Authors: Huibin Huang, Guangjun Jing, Joshua J Wang, Nader Sheibani and Sarah X Zhang

    Citation: Journal of Inflammation 2015 12:31

    Content type: Research

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  17. Citation: Journal of Inflammation 2015 12(Suppl 1):P4

    Content type: Poster presentation

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 1

  18. To investigate whether monosodium urate (MSU) crystals induce interleukin (IL)-1β in human fibroblast-like synoviocytes (FLS), and whether the NLRP3 inflammasome is involved in the inflammatory mechanism.

    Authors: Shu-cong Zheng, Xiao-xia Zhu, Yu Xue, Li-hong Zhang, He-jian Zou, Jian-hua Qiu and Qiong Liu

    Citation: Journal of Inflammation 2015 12:30

    Content type: Research

    Published on:

  19. Recently adipokines have been implicated in the regulation of immune and inflammatory responses in autoimmune disease. To investigate the role of adipokines in adult and pediatric patients with newly diagnosed...

    Authors: Jeannette M Olazagasti, Molly Hein, Cynthia S Crowson, Consuelo Lopez de Padilla, Erik Peterson, Emily C Baechler and Ann M Reed

    Citation: Journal of Inflammation 2015 12:29

    Content type: Research

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  20. Sarcoidosis is a granulomatous disease affecting in particular the lungs. The peroxisome proliferator-activated receptors (PPARs) play important regulatory roles in inflammation. The aim of this study was to g...

    Authors: Muntasir Abo Al Hayja, Anders Eklund, Johan Grunewald and Jan Wahlström

    Citation: Journal of Inflammation 2015 12:28

    Content type: Research

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  21. Up-regulation of regulated upon activation, normal T-cell expressed and secreted (RANTES/CCL5) and adhesion molecules is observed in the serum of animals following experimental subarachnoid hemorrhage (SAH). T...

    Authors: Chih-Zen Chang, Shu-Chuan Wu, Chih-Lung Lin and Aij-Lie Kwan

    Citation: Journal of Inflammation 2015 12:27

    Content type: Research

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  22. Chronic Kidney Disease (CKD) and inflammation are risk factors for atherosclerotic vascular disease (ASVD). In inflammatory conditions, Nuclear Factor-κB (NF-κB) is frequently activated and it has been detecte...

    Authors: Miguel Hueso, Joan Torras, Marta Carrera, August Vidal, Estanis Navarro and Josep Grinyó

    Citation: Journal of Inflammation 2015 12:26

    Content type: Short Report

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  23. We aimed to investigate peripheral blood eosinophil chemotaxis, generation of spontaneous reactive oxygen species (ROS), and apoptosis in patients with allergic asthma after bronchial allergen challenge.

    Authors: Simona Lavinskiene, Kestutis Malakauskas, Jolanta Jeroch, Deimante Hoppenot and Raimundas Sakalauskas

    Citation: Journal of Inflammation 2015 12:25

    Content type: Research

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  24. Cartilage damage is a crucial step in rheumatoid arthritis (RA) disease progress while its molecular mechanisms are not fully understood. Here we investigated the expression of hedgehog (Hh) signal pathway in ...

    Authors: Rong Li, Li Cai, Cheng-mu Hu, Ting-ni Wu and Jun Li

    Citation: Journal of Inflammation 2015 12:24

    Content type: Research

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  25. To explore the immunological mechanisms underlying the effect of chronic intermittent hypobaric hypoxia (CIHH) pretreatment on collagen-induced arthritis (CIA) in rat.

    Authors: Min Shi, Fang Cui, Ai-Jing Liu, Hui-Jie Ma, Ming Cheng, Shu-Xia Song, Fang Yuan, De-Pei Li and Yi Zhang

    Citation: Journal of Inflammation 2015 12:23

    Content type: Research

    Published on:

  26. Apolipoprotein A-IV (apoA-IV) is a protein mainly synthesized by enterocytes in the intestine. Its gene expression is suppressed during fasting and stimulated during active fat absorption. Chronic feeding of a...

    Authors: Xiaoming Li, Min Xu, Min Liu, Yong Ji and Zongfang Li

    Citation: Journal of Inflammation 2015 12:22

    Content type: Research

    Published on:

  27. Sarcoidosis is a systemic disease of unknown etiology characterized histologically by the observation of non-caseating granulomas and several immunological abnormalities. Sarcoidosis is a multi-organ disorder ...

    Authors: Esmaeil Mortaz, Hale Abdoli Sereshki, Atefeh Abedini, Arda Kiani, Mehdi Mirsaeidi, Dina Soroush, Johan Garssen, Aliakbar Velayati, Frank A Redegeld and Ian M Adcock

    Citation: Journal of Inflammation 2015 12:21

    Content type: Research

    Published on:

  28. Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation and progressive decline in pulmonary function. Neutrophil-to-lymphocyte ratio (NLR), YKL-40 and calprotectin are biomarkers...

    Authors: Allan Klitgaard Sørensen, Dennis Back Holmgaard, Lone Hagens Mygind, Julia Johansen and Court Pedersen

    Citation: Journal of Inflammation 2015 12:20

    Content type: Research

    Published on:

  29. Inflammatory bowel disease is an immunologically mediated disease. Notably, it is less common in countries where there is a greater risk of exposure to helminths. In our study, we examined the modulatory effec...

    Authors: Imene Soufli, Ryma Toumi, Hayet Rafa, Manel Amri, Moussa Labsi, Lila Khelifi, Ferdinando Nicoletti and Chafia Touil-Boukoffa

    Citation: Journal of Inflammation 2015 12:19

    Content type: Research

    Published on:

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