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  1. Monocyte chemoattractant protein-1 (MCP-1) is a major chemokine that recruits monocyte/macrophage to the site of tissue injury and plays a critical role in microvascular complications of diabetes. However, the...

    Authors: Huibin Huang, Guangjun Jing, Joshua J Wang, Nader Sheibani and Sarah X Zhang

    Citation: Journal of Inflammation 2015 12:31

    Content type: Research

    Published on:

  2. Citation: Journal of Inflammation 2015 12(Suppl 1):P4

    Content type: Poster presentation

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 1

  3. To investigate whether monosodium urate (MSU) crystals induce interleukin (IL)-1β in human fibroblast-like synoviocytes (FLS), and whether the NLRP3 inflammasome is involved in the inflammatory mechanism.

    Authors: Shu-cong Zheng, Xiao-xia Zhu, Yu Xue, Li-hong Zhang, He-jian Zou, Jian-hua Qiu and Qiong Liu

    Citation: Journal of Inflammation 2015 12:30

    Content type: Research

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  4. Recently adipokines have been implicated in the regulation of immune and inflammatory responses in autoimmune disease. To investigate the role of adipokines in adult and pediatric patients with newly diagnosed...

    Authors: Jeannette M Olazagasti, Molly Hein, Cynthia S Crowson, Consuelo Lopez de Padilla, Erik Peterson, Emily C Baechler and Ann M Reed

    Citation: Journal of Inflammation 2015 12:29

    Content type: Research

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  5. Sarcoidosis is a granulomatous disease affecting in particular the lungs. The peroxisome proliferator-activated receptors (PPARs) play important regulatory roles in inflammation. The aim of this study was to g...

    Authors: Muntasir Abo Al Hayja, Anders Eklund, Johan Grunewald and Jan Wahlström

    Citation: Journal of Inflammation 2015 12:28

    Content type: Research

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  6. Up-regulation of regulated upon activation, normal T-cell expressed and secreted (RANTES/CCL5) and adhesion molecules is observed in the serum of animals following experimental subarachnoid hemorrhage (SAH). T...

    Authors: Chih-Zen Chang, Shu-Chuan Wu, Chih-Lung Lin and Aij-Lie Kwan

    Citation: Journal of Inflammation 2015 12:27

    Content type: Research

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  7. Chronic Kidney Disease (CKD) and inflammation are risk factors for atherosclerotic vascular disease (ASVD). In inflammatory conditions, Nuclear Factor-κB (NF-κB) is frequently activated and it has been detecte...

    Authors: Miguel Hueso, Joan Torras, Marta Carrera, August Vidal, Estanis Navarro and Josep Grinyó

    Citation: Journal of Inflammation 2015 12:26

    Content type: Short Report

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  8. We aimed to investigate peripheral blood eosinophil chemotaxis, generation of spontaneous reactive oxygen species (ROS), and apoptosis in patients with allergic asthma after bronchial allergen challenge.

    Authors: Simona Lavinskiene, Kestutis Malakauskas, Jolanta Jeroch, Deimante Hoppenot and Raimundas Sakalauskas

    Citation: Journal of Inflammation 2015 12:25

    Content type: Research

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  9. Cartilage damage is a crucial step in rheumatoid arthritis (RA) disease progress while its molecular mechanisms are not fully understood. Here we investigated the expression of hedgehog (Hh) signal pathway in ...

    Authors: Rong Li, Li Cai, Cheng-mu Hu, Ting-ni Wu and Jun Li

    Citation: Journal of Inflammation 2015 12:24

    Content type: Research

    Published on:

  10. To explore the immunological mechanisms underlying the effect of chronic intermittent hypobaric hypoxia (CIHH) pretreatment on collagen-induced arthritis (CIA) in rat.

    Authors: Min Shi, Fang Cui, Ai-Jing Liu, Hui-Jie Ma, Ming Cheng, Shu-Xia Song, Fang Yuan, De-Pei Li and Yi Zhang

    Citation: Journal of Inflammation 2015 12:23

    Content type: Research

    Published on:

  11. Apolipoprotein A-IV (apoA-IV) is a protein mainly synthesized by enterocytes in the intestine. Its gene expression is suppressed during fasting and stimulated during active fat absorption. Chronic feeding of a...

    Authors: Xiaoming Li, Min Xu, Min Liu, Yong Ji and Zongfang Li

    Citation: Journal of Inflammation 2015 12:22

    Content type: Research

    Published on:

  12. Sarcoidosis is a systemic disease of unknown etiology characterized histologically by the observation of non-caseating granulomas and several immunological abnormalities. Sarcoidosis is a multi-organ disorder ...

    Authors: Esmaeil Mortaz, Hale Abdoli Sereshki, Atefeh Abedini, Arda Kiani, Mehdi Mirsaeidi, Dina Soroush, Johan Garssen, Aliakbar Velayati, Frank A Redegeld and Ian M Adcock

    Citation: Journal of Inflammation 2015 12:21

    Content type: Research

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  13. Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation and progressive decline in pulmonary function. Neutrophil-to-lymphocyte ratio (NLR), YKL-40 and calprotectin are biomarkers...

    Authors: Allan Klitgaard Sørensen, Dennis Back Holmgaard, Lone Hagens Mygind, Julia Johansen and Court Pedersen

    Citation: Journal of Inflammation 2015 12:20

    Content type: Research

    Published on:

  14. Inflammatory bowel disease is an immunologically mediated disease. Notably, it is less common in countries where there is a greater risk of exposure to helminths. In our study, we examined the modulatory effec...

    Authors: Imene Soufli, Ryma Toumi, Hayet Rafa, Manel Amri, Moussa Labsi, Lila Khelifi, Ferdinando Nicoletti and Chafia Touil-Boukoffa

    Citation: Journal of Inflammation 2015 12:19

    Content type: Research

    Published on:

  15. In inflammatory joint disease, such as osteoarthritis or arthritis, there is an increased level of pro-inflammatory cytokines, such as interleukin-1β. These cytokines stimulate the expression and release of ma...

    Authors: Catherine Baugé, Eva Lhuissier, Nicolas Girard, Céline Quesnelle, Gérard Ewert and Karim Boumediene

    Citation: Journal of Inflammation 2015 12:17

    Content type: Research

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  16. Human parainfluenza virus type 3 (HPIV3), while infecting lower airway epithelial cells induces pneumonia and bronchiolitis in infants and children, and may lead to asthma exacerbations in children and adults....

    Authors: Anna Lewandowska-Polak, Małgorzata Brauncajs, Edyta Paradowska, Marzanna Jarzębska, Marcin Kurowski, Sylwia Moskwa, Zbigniew J Leśnikowski and Marek L Kowalski

    Citation: Journal of Inflammation 2015 12:16

    Content type: Research

    Published on:

  17. Atherosclerosis, the underlying cause of heart attack and strokes, is a progresive dyslipidemic and inflammatory disease where monocyte-derived macrophage cells play a pivotal role. Although most of the mechan...

    Authors: Monica de Gaetano, Kawthar Alghamdi, Simone Marcone and Orina Belton

    Citation: Journal of Inflammation 2015 12:15

    Content type: Research

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  18. Ionizing radiation (IR) activates both pro-and anti-proliferative signal pathways producing an imbalance in cell fate decision. IR is able to regulate several genes and factors involved in cell-cycle progressi...

    Authors: Federica Maria Di Maggio, Luigi Minafra, Giusi Irma Forte, Francesco Paolo Cammarata, Domenico Lio, Cristina Messa, Maria Carla Gilardi and Valentina Bravatà

    Citation: Journal of Inflammation 2015 12:14

    Content type: Review

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  19. Nuclear receptor 4A2 (NR4A2) is an orphan nuclear receptor and constitutively active transcription factor expressed at elevated levels in inflamed joint tissues from patients with arthritis. Inflammatory media...

    Authors: Joseph M McCoy, Dana E Walkenhorst, Keegan S McCauley, Hiba Elaasar, Jordan R Everett and Kimberlee S Mix

    Citation: Journal of Inflammation 2015 12:13

    Content type: Research

    Published on:

  20. The oxidative stress response is a cellular defense mechanism that protects cells from oxidative damage and cancer development. The exact molecular mechanism by which reactive oxygen species (ROS) contribute t...

    Authors: Bilge Debelec-Butuner, Nursah Ertunc and Kemal Sami Korkmaz

    Citation: Journal of Inflammation 2015 12:12

    Content type: Research

    Published on:

  21. Delayed M1 toward M2 macrophage phenotype transition is considered one of the major causes for the impaired healing after myocardial infarction (MI). While searching for molecules that modulate M1 and M2 macro...

    Authors: Long-Shu Zhou, Guo-Long Zhao, Qiang Liu, Shu-Cai Jiang, Yun Wang and Dong-Mei Zhang

    Citation: Journal of Inflammation 2015 12:11

    Content type: Research

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  22. Adipose cells responsible for fat storage are the targets of reactive oxygen species (ROS) like H2O2 and pro-inflammatory agents including TNFα and LPS. Such mediators contribute to oxidative stress and alter inf...

    Authors: Méry Marimoutou, Fanny Le Sage, Jacqueline Smadja, Christian Lefebvre d’Hellencourt, Marie-Paule Gonthier and Christine Robert-Da Silva

    Citation: Journal of Inflammation 2015 12:10

    Content type: Research

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  23. Genetic studies have pointed out that CD226 variants, encoding DNAM-1, could be associated with susceptibility to rheumatoid arthritis. Therefore, we aimed to determine the influence of DNAM-1 on the development ...

    Authors: Muriel Elhai, Gilles Chiocchia, Carmen Marchiol, Franck Lager, Gilles Renault, Marco Colonna, Guenter Bernhardt, Yannick Allanore and Jérôme Avouac

    Citation: Journal of Inflammation 2015 12:9

    Content type: Research

    Published on:

  24. Obesity is regarded as a risk factor for cardiovascular disease. Bone morphogenetic protein 4 (BMP4) is a proinflammatory and profibrotic factor, and the reduced expression of this molecule in obese mice seems...

    Authors: Ting Wu, Qiu-Yang Ling, Cheng Zhong, Tian-Xiao Wang, Lu-Lu Wang, Xiao-Ying Wang, Zhao-Liang Su and Gang-Jun Zong

    Citation: Journal of Inflammation 2015 12:8

    Content type: Research

    Published on:

  25. In sub-Saharan Africa poly-parasite infections are frequently observed in children, and with poly-parasitism modulating immune mechanisms, mediated by cytokines and chemokines, are required to prevent overwhel...

    Authors: Jana Hegewald, Richard G Gantin, Christian J Lechner, Xiangsheng Huang, Abram Agosssou, Yvon F Agbeko, Peter T Soboslay and Carsten Köhler

    Citation: Journal of Inflammation 2015 12:5

    Content type: Research

    Published on:

  26. Plants from the genus Ocimum are used as folk medicine for treating various diseases including inflammatory and immune-related diseases. Numerous reports have suggested plant extracts and their constituents as po...

    Authors: Petrina Kapewangolo, Justin J Omolo, Ronel Bruwer, Pascaline Fonteh and Debra Meyer

    Citation: Journal of Inflammation 2015 12:4

    Content type: Research

    Published on:

  27. To explore the upstream signal transduction mechanisms responsible for the imbalanced expression of glucocorticoid receptor (GR) isoforms in chronic rhinosinusitis (CRS) mucosa.

    Authors: Zhenlin Wang, Peng Li, Qiuhang Zhang, Haili Lv, Junqi Liu and Jinyuan Si

    Citation: Journal of Inflammation 2015 12:3

    Content type: Research

    Published on:

  28. Adenosine is a potent endogenous anti-inflammatory and immunoregulatory molecule. Despite its promise, adenosine’s extremely short half-life in blood limits its clinical application. Here, we examined adenosin...

    Authors: Keizo Kohno, Emiko Ohashi, Osamu Sano, Hajime Kusano, Toshio Kunikata, Norie Arai, Toshiharu Hanaya, Toshio Kawata, Tomoyuki Nishimoto and Shigeharu Fukuda

    Citation: Journal of Inflammation 2015 12:2

    Content type: Research

    Published on:

  29. Milk-derived bioactive peptides retain many biological properties and have therapeutic effects in cardiovascular disorders such as atherosclerosis. Under inflammatory conditions the expression of endothelial c...

    Authors: Simone Marcone, Karen Haughton, Paul J Simpson, Orina Belton and Desmond J Fitzgerald

    Citation: Journal of Inflammation 2015 12:1

    Content type: Research

    Published on:

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