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  1. Content type: Review

    The presence of cytosolic double-stranded DNA molecules can trigger multiple innate immune signalling pathways which converge on the activation of an ER-resident innate immune adaptor named “STimulator of INte...

    Authors: Yang Li, Heather L. Wilson and Endre Kiss-Toth

    Citation: Journal of Inflammation 2017 14:11

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  2. Content type: Short report

    Wnt5A is released by activated macrophages and elevated levels have been detected in sepsis patients with severe systemic inflammation. However, the signalling and functional effects of Wnt5A in the vascular e...

    Authors: Tom Skaria, Esther Bachli and Gabriele Schoedon

    Citation: Journal of Inflammation 2017 14:10

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  3. Content type: Short Report

    Obesity-induced inflammation causes skeletal muscle atrophy accompanied by disruption of oxidative metabolism and is implicated in metabolic complications such as insulin resistance and type 2 diabetes. We pre...

    Authors: Ngoc Hoan Le, Chu-Sook Kim, Thai Hien Tu, Byung-Sam Kim, Taesun Park, Jung Han Yoon Park, Tsuyoshi Goto, Teruo Kawada, Tae Youl Ha and Rina Yu

    Citation: Journal of Inflammation 2017 14:9

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  4. Content type: Research

    Adipocyte fatty acid-binding protein, also known as aP2 or fatty acid-binding protein 4 (FABP4), plays an important role in inflammatory and metabolic responses in adipocytes and macrophages. Recent work has d...

    Authors: Qian Wang, Guanglin Shi, Ying Teng, Xia Li, Jin Xie, Qin Shen, Caixin Zhang, Songshi Ni and Zhiyuan Tang

    Citation: Journal of Inflammation 2017 14:8

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  5. Content type: Research

    Ulinastatin or urinary trypsin inhibitor (UTI) has been shown to ameliorate the inflammatory response induced by experimental severe acute pancreatitis (SAP) and hence reduce the mortality, however the mechani...

    Authors: Yu Pan, Haizong Fang, Fengchun Lu, Minggui Pan, Fei Chen, Ping Xiong, Yi Yao and Heguang Huang

    Citation: Journal of Inflammation 2017 14:7

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  6. Content type: Research

    The dysfunction of articular chondrocytes is a crucial step in rheumatoid arthritis (RA) pathogenesis while its molecular mechanisms are not fully known. This study was aimed to investigate the expression of a...

    Authors: Li Cai, Chao Lei, Rong Li, Wei-na Chen, Cheng-mu Hu, Xiao-yu Chen and Chun-mei Li

    Citation: Journal of Inflammation 2017 14:6

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  7. Content type: Research

    An altered amniotic cytokine profile has been reported in inflammatory pregnancy complications with a leading role for IL-6, a marker of the foetal systemic inflammatory response. Up to this date there is no e...

    Authors: Martina Maritati, Manola Comar, Nunzia Zanotta, Silva Seraceni, Alessandro Trentini, Fabrizio Corazza, Fortunato Vesce and Carlo Contini

    Citation: Journal of Inflammation 2017 14:5

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  8. Content type: Short report

    Peritoneal macrophages are widely used in immunological studies. The cells can be collected under non-elicited (resident) or elicited (e.g., with Brewer thioglycollate broth injection) conditions, and their ph...

    Authors: Sofia Pavlou, Luxi Wang, Heping Xu and Mei Chen

    Citation: Journal of Inflammation 2017 14:4

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  9. Content type: Research

    Statins (HMG CoA reductase inhibitors), in addition to reducing circulating cholesterol and incidence of coronary heart disease, also have pleiotropic, anti-inflammatory effects. Patients with chronic liver di...

    Authors: Peter Fraunberger, Elisabeth Gröne, Hermann-Josef Gröne, Heinz Drexel and Autar K. Walli

    Citation: Journal of Inflammation 2017 14:3

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  10. Content type: Research

    Airway viral infections cause the exacerbations of asthma and chronic obstructive pulmonary disease. PD-L1, also known as B7-H1, is an immune-checkpoint molecule that plays a role in an escape mechanism of vir...

    Authors: Saaka Hamano, Koichiro Matsumoto, Ken Tonai, Satoru Fukuyama, Keiko Kan-o, Nanae Seki, Hiromasa Inoue and Yoichi Nakanishi

    Citation: Journal of Inflammation 2017 14:2

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  11. Content type: Research

    It is well considered that reactive oxygen species (ROS) plays a prominent causative role in the development of allergic rhinitis (AR), and eosinophils cells as important allergic inflammatory cells contribute...

    Authors: Shaoqing Yu, Chuanliang Zhao, Na Che, Lin Jing and Rongming Ge

    Citation: Journal of Inflammation 2017 14:1

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  12. Content type: Research

    The C825T polymorphism (rs5443) of the Guanine Nucleotide-Binding protein subunit β3 (GNB3) gene has been associated with obesity, essential hypertension, atherosclerosis, coronary diseases, and cerebrovascular e...

    Authors: Kokoè Mélinda Gbadoe, Nazha Berdouzi, Alex-Ander Aldasoro Aguiñano, Ndeye Coumba Ndiaye and Sophie Visvikis-Siest

    Citation: Journal of Inflammation 2016 13:39

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  13. Content type: Research

    The innate immune Toll-like receptors (TLRs) 2/4 are important players in chronic low-grade inflammation called metabolic inflammation in obesity and type-2 diabetes (T2D). While TLR2/4 expression changes asso...

    Authors: Rasheed Ahmad, Shihab Kochumon, Reeby Thomas, Valerie Atizado and Sardar Sindhu

    Citation: Journal of Inflammation 2016 13:38

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  14. Content type: Research

    Macrophages serve as intracellular reservoirs of S. aureus. Recent in vitro studies have confirmed high level resistance by S. aureus to macrophage mediated killing and the intracellular persistence of Staphyloco...

    Authors: Somrita Dey and Biswadev Bishayi

    Citation: Journal of Inflammation 2016 13:36

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  15. Content type: Review

    Prostate is an immune-competent organ normally populated by inflammatory cells. Prostatic inflammation origin can be multi-factorial and there are some emerging evidences on its possible role as a factor invol...

    Authors: Alessandro Sciarra, Alessandro Gentilucci, Stefano Salciccia, Federico Pierella, Flavio Del Bianco, Vincenzo Gentile, Ida Silvestri and Susanna Cattarino

    Citation: Journal of Inflammation 2016 13:35

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  16. Content type: Research

    Neuroinflammation (NI) is a key feature in the pathogenesis and progression of infectious and non-infectious neuropathologies, and its amelioration usually improves the patient outcome. Peripheral inflammation...

    Authors: G. Meneses, M. Bautista, A. Florentino, G. Díaz, G. Acero, H. Besedovsky, D. Meneses, A. Fleury, A. Del Rey, G. Gevorkian, G. Fragoso and E. Sciutto

    Citation: Journal of Inflammation 2016 13:33

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  17. Content type: Research

    Osteoarthritis (OA) is described by an imbalance between anabolic and catabolic processes in the affected joint. This dysregulation of metabolism affects not only chondrocytes within cartilage tissue but also ...

    Authors: Christoph Bauer, Eugenia Niculescu-Morzsa, Vivek Jeyakumar, Daniela Kern, Stephan S. Späth and Stefan Nehrer

    Citation: Journal of Inflammation 2016 13:31

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  18. Content type: Research

    Adipokines have a wide range of effects and are linked to sepsis and septic shock. The aim of the present study was to describe the changes in adipokine levels in septic patients in relation to patients’ prese...

    Authors: Andreas Hillenbrand, Pengfei Xu, Shaoxia Zhou, Annette Blatz, Manfred Weiss, Sebastian Hafner, Doris Henne-Bruns and Uwe Knippschild

    Citation: Journal of Inflammation 2016 13:30

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  19. Content type: Research

    Interleukin (IL)-1β is involved in the pathology of intervertebral disc degeneration. Under normal conditions, IL-1β is present in cells in an inactive form (pro-IL-1β). However, under pathological conditions,...

    Authors: Frank J. Brand III, Mahtab Forouzandeh, Harmanpreet Kaur, Francesco Travascio and Juan Pablo de Rivero Vaccari

    Citation: Journal of Inflammation 2016 13:29

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  20. Content type: Research

    Liver regeneration following 70 % partial hepatectomy (PH) requires the coordinated expression of soluble mediators produced by macrophages. Monocyte chemoattractant protein-1 (MCP-1) is a potent stimulus of m...

    Authors: Stephanie L. Wyler, Shawna L. D’Ingillo, Cheri L. Lamb and Kristen A. Mitchell

    Citation: Journal of Inflammation 2016 13:28

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  21. Content type: Research

    Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that are implicated in the regulation of lipid and glucose homeostasis. PPAR agonists have been shown to control i...

    Authors: Julia Naidenow, Igor Hrgovic, Monika Doll, Tsige Hailemariam-Jahn, Victoria Lang, Johannes Kleemann, Stefan Kippenberger, Roland Kaufmann, Nadja Zöller and Markus Meissner

    Citation: Journal of Inflammation 2016 13:27

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  22. Content type: Research

    The pathogenesis of non-allergic rhinitis (NAR) is still largely unknown. Furthermore, it is unclear whether there is a correlation between the effect of nasal glucocorticoids on nasal inflammation and on nasa...

    Authors: Donatella Poletti, Valeria Iannini, Paolo Casolari, Marco Contoli, Alberto Papi, Paul Kirkham, Trevor T. Hansel, Kian Fan Chung, Peter J. Barnes, Antonio Pastore, Stefano Pelucchi, Ian M. Adcock and Gaetano Caramori

    Citation: Journal of Inflammation 2016 13:26

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  23. Content type: Research

    Obesity is associated with vascular inflammation, fibrosis and reduced high-density lipoproteins (HDL)-cholesterol. We aimed to investigate whether adenoviral gene transfer with human apolipoprotein (apo) A-I (Ad...

    Authors: Frank Spillmann, Bart De Geest, Ilayaraja Muthuramu, Ruhul Amin, Kapka Miteva, Burkert Pieske, Carsten Tschöpe and Sophie Van Linthout

    Citation: Journal of Inflammation 2016 13:25

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  24. Content type: Research

    Endotoxemia is commonly reported in patients receiving haemodialysis and implicated in the pathogenesis of systemic inflammation. The Limulus Amoebocyte Lysate (LAL) assay is the most commonly used blood endot...

    Authors: Jonathan Wong, Nathan Davies, Hasan Jeraj, Enric Vilar, Adie Viljoen and Ken Farrington

    Citation: Journal of Inflammation 2016 13:24

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  25. Content type: Short Report

    Behcet’s disease (BD) is characterized by systemic recurrent inflammation with increased production of tumor necrosis factor (TNF)–α and interleukin (IL)-6 by peripheral blood mononuclear cells (PBMCs). To gai...

    Authors: Min-Yeong Woo, Su Jin Yun, Okki Cho, Kyongmin Kim, Eun-So Lee and Sun Park

    Citation: Journal of Inflammation 2016 13:22

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  26. Content type: Research

    Non-psychotropic atypical cannabinoids have therapeutic potential in a variety of inflammatory conditions including those of the gastrointestinal tract. Here we examined the effects of the atypical cannabinoid...

    Authors: Regina M. Krohn, Sean A. Parsons, Jakub Fichna, Kamala D. Patel, Robin M. Yates, Keith A. Sharkey and Martin A. Storr

    Citation: Journal of Inflammation 2016 13:21

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  27. Content type: Research

    Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by highly pruritic eczematous lesions that are commonly treated with topical corticosteroids and calcineurin inhibitors. Side-effects...

    Authors: Niklas Palmqvist, Max Siller, Cecilia Klint and Anders Sjödin

    Citation: Journal of Inflammation 2016 13:20

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  28. Content type: Research

    Endothelin-1 (ET-1) is involved in pulmonary vascular remodeling. The aim of this study was to investigate the biochemical interactions between PPAR-γ, TGF-β1 and ET-1 in vitro.

    Authors: Shulin Xiang, Yi Zeng, Bin Xiong, Yueqiu Qin, Xia Huang, Yujie Jiang, Weigui Luo, Suren R. Sooranna and Liao Pinhu

    Citation: Journal of Inflammation 2016 13:19

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  29. Content type: Research

    Erythropoietin (EPO) has been demonstrated to enhance recovery in ischemic organs through enhancing angiogenesis. In this study, we used an experimental critical limb ischemia (CLI) rat model to reveal the und...

    Authors: Han-Tan Chai, Hon-Kan Yip, Cheuk-Kwan Sun, Shu-Yuan Hsu and Steve Leu

    Citation: Journal of Inflammation 2016 13:18

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  30. Content type: Research

    Cytosine-phosphate-guanine (CpG) oligodeoxyribonucleotides (ODNs) are synthetic DNA fragments containing unmethylated cytosine-guanine motifs with potential immune modulatory effects and have recently been sug...

    Authors: Xuan Li, Guoxiong Xu, Tiankui Qiao, Sujuan Yuan, Xibing Zhuang, Jihong Zhang and Hui Bin Sun

    Citation: Journal of Inflammation 2016 13:16

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  31. Content type: Research

    In rheumatoid arthritis (RA), synovial fibroblasts (SF) secrete large amounts of IL-6, IL-8 and matrix metalloproteinases (MMPs) which are crucial for cartilage destruction. RASFs are sensitive to the action o...

    Authors: Torsten Lowin, Georg Pongratz and Rainer H. Straub

    Citation: Journal of Inflammation 2016 13:15

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  32. Content type: Research

    Intimate links connect tissue factor (TF), the principal initiator of the clotting cascade, to inflammation, a cross-talk amplified by locally generated Angiotensin (AT) II, the effector arm of the Renin Angio...

    Authors: Cristina Balia, Valentina Scalise, Silvana Cianchetti, Francesca Faita, Tommaso Neri, Vittoria Carnicelli, Riccardo Zucchi, Alessandro Celi and Roberto Pedrinelli

    Citation: Journal of Inflammation 2016 13:14

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  33. Content type: Research

    Hyperglycemia is a frequent and important metabolic derangement that accompanies severe sepsis and septic shock. Matrix-Metalloproteinase 9 (MMP-9) has been shown to be elevated in acute stress hyperglycemia, ...

    Authors: Gul R. Sachwani, Anja K. Jaehne, Namita Jayaprakash, Mark Kuzich, Violet Onkoba, Dione Blyden and Emanuel P. Rivers

    Citation: Journal of Inflammation 2016 13:13

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  34. Content type: Research

    Resident macrophages in OA synovial tissue contribute to synovitis through pro-inflammatory mediators driving cartilage loss. What remains unknown is how these macrophages interact with synovial mesenchymal pr...

    Authors: Akash Fichadiya, Karri L Bertram, Guomin Ren, Robin M Yates and Roman J Krawetz

    Citation: Journal of Inflammation 2016 13:12

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  35. Content type: Review

    Eosinophilic chronic rhinosinusitis (ECRS) is considered a refractory and intractable disease. Patients with ECRS present with thick mucus production, long-term nasal congestion, loss of sense of smell, and in...

    Authors: Said Ahmad Shah, Hajime Ishinaga and Kazuhiko Takeuchi

    Citation: Journal of Inflammation 2016 13:11

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  36. Content type: Research

    Pretreatment with low doses of LPS (lipopolysaccharide, bacterial endotoxin) reduces the pro-inflammatory response to a subsequent higher LPS dose, a phenomenon known as endotoxin tolerance. Moreover, hydrogen...

    Authors: Ester C. S. Rios, Francisco G. Soriano, Gabor Olah, Domokos Gerö, Bartosz Szczesny and Csaba Szabo

    Citation: Journal of Inflammation 2016 13:10

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  37. Content type: Research

    It has long been known that an intrastriatal microinjection of the archetypal pro-inflammatory cytokine, interleukin-1beta (IL-1β), in juvenile rats induces a chronic reduction in the apparent diffusion coeffi...

    Authors: Raman Saggu

    Citation: Journal of Inflammation 2016 13:9

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    The Erratum to this article has been published in Journal of Inflammation 2016 13:17

  38. Content type: Research

    The amount of urinary glycoprotein lipocalin 2 (LCN2) has been known to increase after kidney injury because of failed reabsorption by the proximal tubules or direct secretion from injured tissues. However, th...

    Authors: Yoko Fujiwara, Hiroyoshi Tsuchiya, Nobuya Sakai, Katsushi Shibata, Akio Fujimura and Taka-aki Koshimizu

    Citation: Journal of Inflammation 2016 13:7

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  39. Content type: Research

    Diabetes is quickly becoming the most widespread disorder in the Western world. Among the most prevalent effects of diabetes is atherosclerosis, which in turn is driven in part by inflammation. Both insulin an...

    Authors: Gregory B. Pott, Mark Tsurudome, Nadia Bamfo and Marc L. Goalstone

    Citation: Journal of Inflammation 2016 13:6

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  40. Content type: Short report

    The secreted goblet cell protein CLCA1 (chloride channel regulator, calcium-activated-1) is, in addition to its established role in epithelial chloride conductance regulation, thought to act as a multifunction...

    Authors: Nancy A. Erickson, Lars Mundhenk, Samoa Giovannini, Rainer Glauben, Markus M. Heimesaat and Achim D. Gruber

    Citation: Journal of Inflammation 2016 13:5

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  41. Content type: Short report

    Nur77, a key member of the NR4A receptor subfamily, is involved in the regulation of inflammation and immunity. However, the in vivo regulatory roles of Nur77 in sepsis and the mechanisms involved remains larg...

    Authors: Xiu-Ming Li, Shen Zhang, Xiao-Shun He, Peng-Da Guo, Xing-Xing Lu, Jing-Ru Wang, Jian-Ming Li and Hua Wu

    Citation: Journal of Inflammation 2016 13:4

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  42. Content type: Research

    In this study we sought to determine if application of bone morphogenic protein 7 (BMP-7) promotes physiological bone healing of non-unions and to investigate if serum cytokine analysis may serve as a promisin...

    Authors: Arash Moghaddam, Lisa Breier, Patrick Haubruck, Daniel Bender, Bahram Biglari, Andreas Wentzensen and Gerald Zimmermann

    Citation: Journal of Inflammation 2016 13:3

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  43. Content type: Review

    CXCL14, a relatively novel chemokine, is a non-ELR (glutamic acid-leucine-arginine) chemokine with a broad spectrum of biological activities. CXCL14 mainly contributes to the regulation of immune cell migratio...

    Authors: Jing Lu, Mita Chatterjee, Hannes Schmid, Sandra Beck and Meinrad Gawaz

    Citation: Journal of Inflammation 2016 13:1

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Affiliated with the British Inflammation Research Association (BIRAs).

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