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  1. Content type: Research

    Septic shock remains a leading cause of death worldwide. Hyperbaric oxygen treatment (HBO2) has been shown to alter the inflammatory response during sepsis and to reduce mortality. A therapeutic window of HBO2 tr...

    Authors: Nina Falcon Bærnthsen, Marco Bo Hansen, Anna Mygind Wahl, Ulf Simonsen and Ole Hyldegaard

    Citation: Journal of Inflammation 2017 14:27

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  2. Content type: Review

    Primary Sjögren’s syndrome is an autoimmune disease characterized by dry eye and dry mouth. We systematically reviewed all the randomized controlled clinical trials published in the last 15 years that included...

    Authors: Kendrick Co Shih, Christie Nicole Lun, Vishal Jhanji, Bernard Yu-Hor Thong and Louis Tong

    Citation: Journal of Inflammation 2017 14:26

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  3. Content type: Research

    Hyperoside (Hyp) is a flavonoid glycoside compound that has been demonstrated to have anti-inflammatory, anti-apoptotic and antioxidant effects. However, the impact of Hyp on inflammatory bowel disease (IBD) h...

    Authors: Lei Yang, Lei Shen, Yue Li, Yanxia Li, Shijie Yu and Shanshan Wang

    Citation: Journal of Inflammation 2017 14:25

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  4. Content type: Research

    Inflammatory cytokines have been demonstrated to be involved in developing insulin resistance and type-2 diabetes (T2D). Natural antibodies in the circulation have protective effects on common diseases in huma...

    Authors: Weiyi Cai, Cailing Qiu, Hongyu Zhang, Xiangyun Chen, Xuan Zhang, Qingyong Meng and Jun Wei

    Citation: Journal of Inflammation 2017 14:24

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  5. Content type: Research

    Multi-organ failure (MOF) following trauma remains a significant cause of morbidity and mortality related to a poorly understood abnormal inflammatory response. We characterized the inflammatory response in a ...

    Authors: Matthew J. Bradley, Diego A. Vicente, Benjamin A. Bograd, Erin M. Sanders, Crystal L. Leonhardt, Eric A. Elster and Thomas A. Davis

    Citation: Journal of Inflammation 2017 14:23

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  6. Content type: Research

    This study was aimed to evaluate the effect of LPS in glucocorticoid receptor (GR) isoforms expression on different cell lines and PBMC from healthy donors in vitro and glucocorticoid sensitivity of PBMC in vi...

    Authors: Maria Luisa Molina, Julia Guerrero, John A. Cidlowski, Héctor Gatica and Annelise Goecke

    Citation: Journal of Inflammation 2017 14:22

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  7. Content type: Short Report

    In this study, a competitive hepcidin ELISA assay was evaluated for its ability to differentiate between iron deficiency anaemia with concurrent inflammation and anaemia of inflammation in elderly patients, us...

    Authors: Torbjörn Karlsson

    Citation: Journal of Inflammation 2017 14:21

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  8. Content type: Research

    The role of bronchiolar epithelial cells in the pathogenesis of pulmonary fibrosis has not been clarified. We previously demonstrated DNA damage in murine bronchioles in the early stages of bleomycin-induced p...

    Authors: Tetsuya Yokoyama, Toyoshi Yanagihara, Kunihiro Suzuki, Naoki Hamada, Kazuya Tsubouchi, Saiko Ogata-Suetsugu, Hironori Mikumo, Chika Ikeda-Harada, Takashige Maeyama, Kazuyoshi Kuwano and Yoichi Nakanishi

    Citation: Journal of Inflammation 2017 14:20

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  9. Content type: Research

    Sepsis is a life-threatening condition and obesity is related to the clinical outcome. The underlying reasons are incompletely understood, but the adipocyte derived hormones leptin and adiponectin may be invol...

    Authors: Sofie Jacobsson, Peter Larsson, Göran Johansson, Margareta Norberg, Göran Wadell, Göran Hallmans, Ola Winsö and Stefan Söderberg

    Citation: Journal of Inflammation 2017 14:19

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  10. Content type: Research

    Intracranial infection, one of the complications of traumatic brain injury, is usually associated with inflammation. Several microRNAs (miRNAs), including miR-155, have been reported to be critical modulators ...

    Authors: Haiyan Yin, Shuwen Song and Xudong Pan

    Citation: Journal of Inflammation 2017 14:17

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    The Correction to this article has been published in Journal of Inflammation 2018 15:6

  11. Content type: Review

    Interleukin (IL)-35 is a relatively newly discovered member of IL-12 cytokine family that is unique in that it is a dimer formed by two subunits. The review documents the structure, secretion and signal transd...

    Authors: Ai Huang, Lin Cheng, Miao He, Jun Nie, Jianjun Wang and Ke Jiang

    Citation: Journal of Inflammation 2017 14:16

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  12. Content type: Research

    Indeed, intracerebral hemorrhage (ICH) account for only 15% of all strokes but it is one of the most devastating subtype of stroke associated with behavioral, cognitive and neurological deficits. The primary c...

    Authors: Navdeep Singh, Yashika Bansal, Ranjana Bhandari, Lovish Marwaha, Raghunath Singh, Kanwaljit Chopra and Anurag Kuhad

    Citation: Journal of Inflammation 2017 14:14

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  13. Content type: Research

    Traumatic brain injury (TBI) is a public health issue. As the major complaint in 51% of TBI patients, chronic pain is an important aspect in TBI treatment. Tetramethylpyrazine (TMP) is an important compound in Li...

    Authors: Zhijing Wang, Qi Wang, Cuijie Wang, Xiuzhen Xu and Hongmei Yu

    Citation: Journal of Inflammation 2017 14:13

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  14. Content type: Research

    The red cell distribution width (RDW) is a widely available, inexpensive, and highly reproducible test that reflects the range of the red cell sizes. Any process that releases reticulocytes in the circulation ...

    Authors: Tom Schepens, Jozef J. De Dooy, Walter Verbrugghe and Philippe G. Jorens

    Citation: Journal of Inflammation 2017 14:12

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  15. Content type: Review

    The presence of cytosolic double-stranded DNA molecules can trigger multiple innate immune signalling pathways which converge on the activation of an ER-resident innate immune adaptor named “STimulator of INte...

    Authors: Yang Li, Heather L. Wilson and Endre Kiss-Toth

    Citation: Journal of Inflammation 2017 14:11

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  16. Content type: Short report

    Wnt5A is released by activated macrophages and elevated levels have been detected in sepsis patients with severe systemic inflammation. However, the signalling and functional effects of Wnt5A in the vascular e...

    Authors: Tom Skaria, Esther Bachli and Gabriele Schoedon

    Citation: Journal of Inflammation 2017 14:10

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  17. Content type: Short Report

    Obesity-induced inflammation causes skeletal muscle atrophy accompanied by disruption of oxidative metabolism and is implicated in metabolic complications such as insulin resistance and type 2 diabetes. We pre...

    Authors: Ngoc Hoan Le, Chu-Sook Kim, Thai Hien Tu, Byung-Sam Kim, Taesun Park, Jung Han Yoon Park, Tsuyoshi Goto, Teruo Kawada, Tae Youl Ha and Rina Yu

    Citation: Journal of Inflammation 2017 14:9

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  18. Content type: Research

    Adipocyte fatty acid-binding protein, also known as aP2 or fatty acid-binding protein 4 (FABP4), plays an important role in inflammatory and metabolic responses in adipocytes and macrophages. Recent work has d...

    Authors: Qian Wang, Guanglin Shi, Ying Teng, Xia Li, Jin Xie, Qin Shen, Caixin Zhang, Songshi Ni and Zhiyuan Tang

    Citation: Journal of Inflammation 2017 14:8

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  19. Content type: Research

    Ulinastatin or urinary trypsin inhibitor (UTI) has been shown to ameliorate the inflammatory response induced by experimental severe acute pancreatitis (SAP) and hence reduce the mortality, however the mechani...

    Authors: Yu Pan, Haizong Fang, Fengchun Lu, Minggui Pan, Fei Chen, Ping Xiong, Yi Yao and Heguang Huang

    Citation: Journal of Inflammation 2017 14:7

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  20. Content type: Research

    The dysfunction of articular chondrocytes is a crucial step in rheumatoid arthritis (RA) pathogenesis while its molecular mechanisms are not fully known. This study was aimed to investigate the expression of a...

    Authors: Li Cai, Chao Lei, Rong Li, Wei-na Chen, Cheng-mu Hu, Xiao-yu Chen and Chun-mei Li

    Citation: Journal of Inflammation 2017 14:6

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  21. Content type: Research

    An altered amniotic cytokine profile has been reported in inflammatory pregnancy complications with a leading role for IL-6, a marker of the foetal systemic inflammatory response. Up to this date there is no e...

    Authors: Martina Maritati, Manola Comar, Nunzia Zanotta, Silva Seraceni, Alessandro Trentini, Fabrizio Corazza, Fortunato Vesce and Carlo Contini

    Citation: Journal of Inflammation 2017 14:5

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  22. Content type: Short report

    Peritoneal macrophages are widely used in immunological studies. The cells can be collected under non-elicited (resident) or elicited (e.g., with Brewer thioglycollate broth injection) conditions, and their ph...

    Authors: Sofia Pavlou, Luxi Wang, Heping Xu and Mei Chen

    Citation: Journal of Inflammation 2017 14:4

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  23. Content type: Research

    Statins (HMG CoA reductase inhibitors), in addition to reducing circulating cholesterol and incidence of coronary heart disease, also have pleiotropic, anti-inflammatory effects. Patients with chronic liver di...

    Authors: Peter Fraunberger, Elisabeth Gröne, Hermann-Josef Gröne, Heinz Drexel and Autar K. Walli

    Citation: Journal of Inflammation 2017 14:3

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  24. Content type: Research

    Airway viral infections cause the exacerbations of asthma and chronic obstructive pulmonary disease. PD-L1, also known as B7-H1, is an immune-checkpoint molecule that plays a role in an escape mechanism of vir...

    Authors: Saaka Hamano, Koichiro Matsumoto, Ken Tonai, Satoru Fukuyama, Keiko Kan-o, Nanae Seki, Hiromasa Inoue and Yoichi Nakanishi

    Citation: Journal of Inflammation 2017 14:2

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  25. Content type: Research

    It is well considered that reactive oxygen species (ROS) plays a prominent causative role in the development of allergic rhinitis (AR), and eosinophils cells as important allergic inflammatory cells contribute...

    Authors: Shaoqing Yu, Chuanliang Zhao, Na Che, Lin Jing and Rongming Ge

    Citation: Journal of Inflammation 2017 14:1

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  26. Content type: Research

    The C825T polymorphism (rs5443) of the Guanine Nucleotide-Binding protein subunit β3 (GNB3) gene has been associated with obesity, essential hypertension, atherosclerosis, coronary diseases, and cerebrovascular e...

    Authors: Kokoè Mélinda Gbadoe, Nazha Berdouzi, Alex-Ander Aldasoro Aguiñano, Ndeye Coumba Ndiaye and Sophie Visvikis-Siest

    Citation: Journal of Inflammation 2016 13:39

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  27. Content type: Research

    The innate immune Toll-like receptors (TLRs) 2/4 are important players in chronic low-grade inflammation called metabolic inflammation in obesity and type-2 diabetes (T2D). While TLR2/4 expression changes asso...

    Authors: Rasheed Ahmad, Shihab Kochumon, Reeby Thomas, Valerie Atizado and Sardar Sindhu

    Citation: Journal of Inflammation 2016 13:38

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  28. Content type: Research

    Macrophages serve as intracellular reservoirs of S. aureus. Recent in vitro studies have confirmed high level resistance by S. aureus to macrophage mediated killing and the intracellular persistence of Staphyloco...

    Authors: Somrita Dey and Biswadev Bishayi

    Citation: Journal of Inflammation 2016 13:36

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  29. Content type: Review

    Prostate is an immune-competent organ normally populated by inflammatory cells. Prostatic inflammation origin can be multi-factorial and there are some emerging evidences on its possible role as a factor invol...

    Authors: Alessandro Sciarra, Alessandro Gentilucci, Stefano Salciccia, Federico Pierella, Flavio Del Bianco, Vincenzo Gentile, Ida Silvestri and Susanna Cattarino

    Citation: Journal of Inflammation 2016 13:35

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  30. Content type: Research

    Neuroinflammation (NI) is a key feature in the pathogenesis and progression of infectious and non-infectious neuropathologies, and its amelioration usually improves the patient outcome. Peripheral inflammation...

    Authors: G. Meneses, M. Bautista, A. Florentino, G. Díaz, G. Acero, H. Besedovsky, D. Meneses, A. Fleury, A. Del Rey, G. Gevorkian, G. Fragoso and E. Sciutto

    Citation: Journal of Inflammation 2016 13:33

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  31. Content type: Research

    Osteoarthritis (OA) is described by an imbalance between anabolic and catabolic processes in the affected joint. This dysregulation of metabolism affects not only chondrocytes within cartilage tissue but also ...

    Authors: Christoph Bauer, Eugenia Niculescu-Morzsa, Vivek Jeyakumar, Daniela Kern, Stephan S. Späth and Stefan Nehrer

    Citation: Journal of Inflammation 2016 13:31

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  32. Content type: Research

    Adipokines have a wide range of effects and are linked to sepsis and septic shock. The aim of the present study was to describe the changes in adipokine levels in septic patients in relation to patients’ prese...

    Authors: Andreas Hillenbrand, Pengfei Xu, Shaoxia Zhou, Annette Blatz, Manfred Weiss, Sebastian Hafner, Doris Henne-Bruns and Uwe Knippschild

    Citation: Journal of Inflammation 2016 13:30

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  33. Content type: Research

    Interleukin (IL)-1β is involved in the pathology of intervertebral disc degeneration. Under normal conditions, IL-1β is present in cells in an inactive form (pro-IL-1β). However, under pathological conditions,...

    Authors: Frank J. Brand III, Mahtab Forouzandeh, Harmanpreet Kaur, Francesco Travascio and Juan Pablo de Rivero Vaccari

    Citation: Journal of Inflammation 2016 13:29

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  34. Content type: Research

    Liver regeneration following 70 % partial hepatectomy (PH) requires the coordinated expression of soluble mediators produced by macrophages. Monocyte chemoattractant protein-1 (MCP-1) is a potent stimulus of m...

    Authors: Stephanie L. Wyler, Shawna L. D’Ingillo, Cheri L. Lamb and Kristen A. Mitchell

    Citation: Journal of Inflammation 2016 13:28

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  35. Content type: Research

    Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that are implicated in the regulation of lipid and glucose homeostasis. PPAR agonists have been shown to control i...

    Authors: Julia Naidenow, Igor Hrgovic, Monika Doll, Tsige Hailemariam-Jahn, Victoria Lang, Johannes Kleemann, Stefan Kippenberger, Roland Kaufmann, Nadja Zöller and Markus Meissner

    Citation: Journal of Inflammation 2016 13:27

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  36. Content type: Research

    The pathogenesis of non-allergic rhinitis (NAR) is still largely unknown. Furthermore, it is unclear whether there is a correlation between the effect of nasal glucocorticoids on nasal inflammation and on nasa...

    Authors: Donatella Poletti, Valeria Iannini, Paolo Casolari, Marco Contoli, Alberto Papi, Paul Kirkham, Trevor T. Hansel, Kian Fan Chung, Peter J. Barnes, Antonio Pastore, Stefano Pelucchi, Ian M. Adcock and Gaetano Caramori

    Citation: Journal of Inflammation 2016 13:26

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  37. Content type: Research

    Obesity is associated with vascular inflammation, fibrosis and reduced high-density lipoproteins (HDL)-cholesterol. We aimed to investigate whether adenoviral gene transfer with human apolipoprotein (apo) A-I (Ad...

    Authors: Frank Spillmann, Bart De Geest, Ilayaraja Muthuramu, Ruhul Amin, Kapka Miteva, Burkert Pieske, Carsten Tschöpe and Sophie Van Linthout

    Citation: Journal of Inflammation 2016 13:25

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  38. Content type: Research

    Endotoxemia is commonly reported in patients receiving haemodialysis and implicated in the pathogenesis of systemic inflammation. The Limulus Amoebocyte Lysate (LAL) assay is the most commonly used blood endot...

    Authors: Jonathan Wong, Nathan Davies, Hasan Jeraj, Enric Vilar, Adie Viljoen and Ken Farrington

    Citation: Journal of Inflammation 2016 13:24

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  39. Content type: Short Report

    Behcet’s disease (BD) is characterized by systemic recurrent inflammation with increased production of tumor necrosis factor (TNF)–α and interleukin (IL)-6 by peripheral blood mononuclear cells (PBMCs). To gai...

    Authors: Min-Yeong Woo, Su Jin Yun, Okki Cho, Kyongmin Kim, Eun-So Lee and Sun Park

    Citation: Journal of Inflammation 2016 13:22

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  40. Content type: Research

    Non-psychotropic atypical cannabinoids have therapeutic potential in a variety of inflammatory conditions including those of the gastrointestinal tract. Here we examined the effects of the atypical cannabinoid...

    Authors: Regina M. Krohn, Sean A. Parsons, Jakub Fichna, Kamala D. Patel, Robin M. Yates, Keith A. Sharkey and Martin A. Storr

    Citation: Journal of Inflammation 2016 13:21

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  41. Content type: Research

    Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by highly pruritic eczematous lesions that are commonly treated with topical corticosteroids and calcineurin inhibitors. Side-effects...

    Authors: Niklas Palmqvist, Max Siller, Cecilia Klint and Anders Sjödin

    Citation: Journal of Inflammation 2016 13:20

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  42. Content type: Research

    Endothelin-1 (ET-1) is involved in pulmonary vascular remodeling. The aim of this study was to investigate the biochemical interactions between PPAR-γ, TGF-β1 and ET-1 in vitro.

    Authors: Shulin Xiang, Yi Zeng, Bin Xiong, Yueqiu Qin, Xia Huang, Yujie Jiang, Weigui Luo, Suren R. Sooranna and Liao Pinhu

    Citation: Journal of Inflammation 2016 13:19

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  43. Content type: Research

    Erythropoietin (EPO) has been demonstrated to enhance recovery in ischemic organs through enhancing angiogenesis. In this study, we used an experimental critical limb ischemia (CLI) rat model to reveal the und...

    Authors: Han-Tan Chai, Hon-Kan Yip, Cheuk-Kwan Sun, Shu-Yuan Hsu and Steve Leu

    Citation: Journal of Inflammation 2016 13:18

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