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  1. [1, 2, 4] triazolo [4, 3-a][1, 8]naphthyridine derivatives (including NF161 and NF177) were tested for anti-inflammatory, analgesic and antipyretic properties and for their effects on spontaneous locomotor activi...

    Authors: Chiara Dianzani, Massimo Collino, Margherita Gallicchio, Mario Di Braccio, Giorgio Roma and Roberto Fantozzi

    Citation: Journal of Inflammation 2006 3:4

    Content type: Research

    Published on:

  3. Pulmonary fibrosis is characterized by excessive deposition of extracellular matrix in the interstitium resulting in respiratory failure. The role of remodeling mediators such as metalloproteinases (MMPs) and ...

    Authors: Boris Manoury, Soazig Nenan, Isabelle Guenon, Elisabeth Boichot, Jean-Michel Planquois, Claude P Bertrand and Vincent Lagente

    Citation: Journal of Inflammation 2006 3:2

    Content type: Research

    Published on:

  4. French maritime pine bark extract (Pycnogenol®) displays a variety of anti-inflammatory effects in vivo. Aim of this study was to determine whether human plasma after oral intake of Pycnogenol contains sufficient...

    Authors: Tanja Grimm, Zuzana Chovanová, Jana Muchová, Katarína Sumegová, Anna Liptáková, Zdeňka Ďuračková and Petra Högger

    Citation: Journal of Inflammation 2006 3:1

    Content type: Research

    Published on:

  5. Bacterial and viral exacerbations play a crucial role in a variety of lung diseases including COPD or asthma. Since the lung epithelium is a major source of various inflammatory mediators that affect the immun...

    Authors: Mirko Ritter, Detlev Mennerich, Andreas Weith and Peter Seither

    Citation: Journal of Inflammation 2005 2:16

    Content type: Research

    Published on:

  6. Nurr1 is an orphan member of the nuclear receptor superfamily; these orphan receptors are a group for which a ligand has yet to be identified. Nurr1 has been shown to regulate the expression of a small number ...

    Authors: Mark R Davies, Christine J Harding, Stephanie Raines, Kurt Tolley, Andrew E Parker, Mark Downey-Jones and Maurice RC Needham

    Citation: Journal of Inflammation 2005 2:15

    Content type: Research

    Published on:

  7. Peripheral blood monocytes and monocyte-derived macrophages are key regulatory components in many chronic inflammatory pathologies of the vasculature including the formation of atherosclerotic lesions. However...

    Authors: Roderick J Phillips, Marin Lutz and Brett Premack

    Citation: Journal of Inflammation 2005 2:14

    Content type: Research

    Published on:

  8. Genetic deficiency in the expression of interleukin-10 (IL-10) is associated with the onset and progression of experimental inflammatory bowel disease (IBD). The clinical significance of IL-10 expression is su...

    Authors: Makoto Sasaki, J Michael Mathis, Merilyn H Jennings, Paul Jordan, Yuping Wang, Tomoaki Ando, Takashi Joh and J Steven Alexander

    Citation: Journal of Inflammation 2005 2:13

    Content type: Research

    Published on:

  9. Viruses remain one of the inducers of the stress response in the infected cells. Heat shock response induced by vaccinia virus (VV) infection was studied in vitro in human blood monocyte derived macrophages (M...

    Authors: Aleksandra Kowalczyk, Krzysztof Guzik, Kinga Slezak, Jakub Dziedzic and Hanna Rokita

    Citation: Journal of Inflammation 2005 2:12

    Content type: Research

    Published on:

  10. This study was designed to determine if a natural mineral supplement, sierrasil, alone and in combination with a cat's claw extract (Uncaria guianensis), vincaria, has therapeutic potential in mild to moderate os...

    Authors: Mark JS Miller, Komal Mehta, Sameer Kunte, Vidyanand Raut, Jayesh Gala, Ramesh Dhumale, Anil Shukla, Hemant Tupalli, Himanshu Parikh, Paul Bobrowski and Jayesh Chaudhary

    Citation: Journal of Inflammation 2005 2:11

    Content type: Research

    Published on:

  11. IκBα is an inhibitor of the nuclear transcription factor NF-κB. Binding of IκBα to NF-κB inactivates the transcriptional activity of NF-κB. Expression of IκBα itself is regulated by NF-κB, which provides auto-...

    Authors: Ning Zhang, Muhammad H Ahsan, Lingyun Zhu, Lidia C Sambucetti, Anthony F Purchio and David B West

    Citation: Journal of Inflammation 2005 2:10

    Content type: Research

    Published on:

  13. Adult bone marrow derived mesenchymal stem cells offer the potential to open a new frontier in medicine. Regenerative medicine aims to replace effete cells in a broad range of conditions associated with damage...

    Authors: Jennifer M Ryan, Frank P Barry, J Mary Murphy and Bernard P Mahon

    Citation: Journal of Inflammation 2005 2:8

    Content type: Review

    Published on:

  14. Tumor necrosis factor (TNF) is a pleiotropic cytokine involved in a broad spectrum of inflammatory and immune responses including proliferation, differentiation, and cell death. The biological effects of TNF a...

    Authors: Christoph Scherübl, Wulf Schneider-Brachert, Stephan Schütze, Thomas Hehlgans and Daniela N Männel

    Citation: Journal of Inflammation 2005 2:7

    Content type: Research

    Published on:

  15. Parthenolide, a major sesquiterpene lactone present in extracts of the herb Feverfew, has been investigated for its inhibitory effects on mediators of inflammation, including the proinflammatory cytokines. Alt...

    Authors: Alexa T Smolinski and James J Pestka

    Citation: Journal of Inflammation 2005 2:6

    Content type: Research

    Published on:

  16. It has been reported that C-reactive protein (CRP) binds both leukocyte FcγRIIA (CD32) and the plasma membrane of apoptotic cells. Since FcγRIIA becomes functionally enabled during neutrophil apoptosis, we sou...

    Authors: Simon P Hart, Karen M Alexander, Shonna M MacCall and Ian Dransfield

    Citation: Journal of Inflammation 2005 2:5

    Content type: Research

    Published on:

  17. Respiratory viral infections are characterized by the infiltration of leukocytes, including activated neutrophils into the lung that can lead to sustained lung injury and potentially contribute to chronic lung...

    Authors: Vedang A Londhe, John A Belperio, Michael P Keane, Marie D Burdick, Ying Ying Xue and Robert M Strieter

    Citation: Journal of Inflammation 2005 2:4

    Content type: Research

    Published on:

  18. Interleukin 9 (IL-9) is produced by activated CD4+ T cells. Its effects include stimulation of mucus production, enhanced mast cell proliferation, enhanced eosinophil function, and IgE production. These effect...

    Authors: Lauren E Holz, Kristoffer P Jakobsen, Jacques Van Snick, Francoise Cormont and William A Sewell

    Citation: Journal of Inflammation 2005 2:3

    Content type: Research

    Published on:

  19. Recent findings have established an association between obesity and immune dysfunction. However, most of the studies investigating the effects of obesity on immune function have been carried out in genetically...

    Authors: Sammy Bedoui, Elena Velkoska, Steve Bozinovski, Jessica E Jones, Gary P Anderson and Margaret J Morris

    Citation: Journal of Inflammation 2005 2:2

    Content type: Research

    Published on:

  20. Previous studies suggested that essential oils suppressed the adherence response of human neutrophils in vitro and that intraperitoneal application of geranium oil suppressed the neutrophil accumulation into peri...

    Authors: Naho Maruyama, Yuka Sekimoto, Hiroko Ishibashi, Shigeharu Inouye, Haruyuki Oshima, Hideyo Yamaguchi and Shigeru Abe

    Citation: Journal of Inflammation 2005 2:1

    Content type: Research

    Published on:

  22. The critical role of inappropriate inflammation is becoming accepted in many diseases that affect man, including cardiovascular diseases, inflammatory and autoimmune disorders, neurodegenerative conditions, in...

    Authors: Gary Robert Smith and Sotiris Missailidis

    Citation: Journal of Inflammation 2004 1:3

    Content type: Review

    Published on:

  24. Welcome to the Journal of Inflammation, the first open-access, peer-reviewed, online journal to focus on all aspects of the study of inflammation and inflammatory conditions. While research into inflammation has ...

    Authors: Neville A Punchard, Cliff J Whelan and Ian Adcock

    Citation: Journal of Inflammation 2004 1:1

    Content type: Editorial

    Published on:

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