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  1. Intercellular adhesion molecule-1 (ICAM-1) is a critical target-docking molecule on epithelial cells for 90% of human rhinovirus (HRV) serotypes. Two forms of ICAM-1 exist, membranous (mICAM-1) and soluble (sI...

    Authors: Suzanne C Whiteman and Monica A Spiteri

    Citation: Journal of Inflammation 2008 5:8

    Content type: Research

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  2. Bee venom therapy has been used to treat inflammatory diseases including rheumatoid arthritis in humans and in experimental animals. We previously found that bee venom and melittin (a major component of bee ve...

    Authors: Hye Ji Park, Hwa Jeong Lee, Myung Sook Choi, Dong Ju Son, Ho Sueb Song, Min Jong Song, Jeong Min Lee, Sang Bae Han, Youngsoo Kim and Jin Tae Hong

    Citation: Journal of Inflammation 2008 5:7

    Content type: Research

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  3. The tripeptide feG (D-Phe-D-Glu-Gly) is a potent anti-inflammatory peptide that reduces the severity of type I immediate hypersensitivity reactions, and inhibits neutrophil chemotaxis and adhesion to tissues. ...

    Authors: Ronald D Mathison, Emily Christie and Joseph S Davison

    Citation: Journal of Inflammation 2008 5:6

    Content type: Research

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  4. The epidermal growth factor (EGF) and EGF receptor (EGFR) families play important roles in the hyperplastic growth of several tissues as well as tumor growth. Since synovial hyperplasia in rheumatoid arthritis...

    Authors: Shoji Yamane, Satoru Ishida, Yukie Hanamoto, Ken-ichi Kumagai, Riako Masuda, Konagi Tanaka, Noriyuki Shiobara, Noriko Yamane, Toshihito Mori, Takuo Juji, Naoshi Fukui, Tsunetoshi Itoh, Takahiro Ochi and Ryuji Suzuki

    Citation: Journal of Inflammation 2008 5:5

    Content type: Research

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  5. Farnesyltransferase inhibitors (FTI) are small molecule agents originally formulated to inhibit the oncogenic functions of Ras. Although subsequent analysis of FTI activity revealed wider effects on other path...

    Authors: Katharine C DeGeorge, Brent R DeGeorge Jr, James S Testa and Jay L Rothstein

    Citation: Journal of Inflammation 2008 5:3

    Content type: Research

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  6. HIV-specific T-lymphocyte responses that underlie IRIS are incomplete and largely remain hypothetical. Of the several mechanisms presented by the host to control host immunological damage, Treg cells are belie...

    Authors: Esaki Muthu Shankar, Ramachandran Vignesh, Vijayakumar Velu, Kailapuri G Murugavel, Ramalingam Sekar, Pachamuthu Balakrishnan, Charmaine AC Lloyd, Shanmugam Saravanan, Suniti Solomon and Nagalingeswaran Kumarasamy

    Citation: Journal of Inflammation 2008 5:2

    Content type: Hypothesis

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  7. This study tested the ability of a characterized extract of Polygonum cuspidatum (PCE) to inhibit mouse ear inflammation in response to topical application of 12-O- tetradecanoylphorbol-13-acetate (TPA).

    Authors: Eve E Bralley, Phillip Greenspan, James L Hargrove, Louise Wicker and Diane K Hartle

    Citation: Journal of Inflammation 2008 5:1

    Content type: Research

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  8. Nuclear factor kappa B (NF-κB) has been shown to play an important role in regulating the expression of many genes involved in cell survival, immunity and in the inflammatory processes. NF-κB activation upregu...

    Authors: Edward Jones, Ian M Adcock, Bushra Y Ahmed and Neville A Punchard

    Citation: Journal of Inflammation 2007 4:23

    Content type: Research

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  9. It was hypothesized that a pro-atherogenic, high saturated fat and cholesterol diet (HCD) would increase the inflammatory response to E. coli endotoxin (LPS) and increase its concentration in plasma after adminis...

    Authors: Hong Huang, Tongzheng Liu, Jane L Rose, Rachel L Stevens and Dale G Hoyt

    Citation: Journal of Inflammation 2007 4:22

    Content type: Research

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  10. The arterial in line application of the leukocyte inhibition module (LIM) in the cardiopulmonary bypass (CPB) limits overshooting leukocyte activity during cardiac surgery. We studied in a porcine model whethe...

    Authors: Ulf Abdel-Rahman, Stefan Margraf, Tayfun Aybek, Tim Lögters, José Bitu-Moreno, Ieda Francischetti, Tilmann Kranert, Frank Grünwald, Joachim Windolf, Anton Moritz and Martin Scholz

    Citation: Journal of Inflammation 2007 4:21

    Content type: Research

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  11. Cystine/glutamate transporter, system xc-, contributes to the maintenance of intracellular glutathione levels and the redox balance in the extracellular space. The main component of the transporter, xCT, is kn...

    Authors: Kumiko Taguchi, Michiko Tamba, Shiro Bannai and Hideyo Sato

    Citation: Journal of Inflammation 2007 4:20

    Content type: Research

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  12. The recruitment of mononuclear cells has important implications for tissue inflammation. Previous studies demonstrated enhanced CCR1 and CCR5 expression and decreased CCR2 expression during in vitro monocyte to m...

    Authors: Judy M Opalek, Naeem A Ali, Jennifer M Lobb, Melissa G Hunter and Clay B Marsh

    Citation: Journal of Inflammation 2007 4:19

    Content type: Research

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  13. Idiopathic Pulmonary Fibrosis (IPF) is a progressive diffuse disease involving the lung parenchyma. Despite recent advances, the molecular mechanisms of the initiation and progression of this disease remain el...

    Authors: Yussef Haider, Andrea P Malizia, Dominic T Keating, Mary Birch, Annette Tomlinson, Gail Martin, Mark WJ Ferguson, Peter P Doran and Jim J Egan

    Citation: Journal of Inflammation 2007 4:18

    Content type: Research

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  14. Evidence from epidemiological, clinical and animal studies suggests a link may exist between low bone density and cardiovascular disease, with inflammatory mediators implicated in the pathophysiology of both c...

    Authors: Elizabeth A Droke, Kelly A Hager, Megan R Lerner, Stan A Lightfoot, Barbara J Stoecker, Daniel J Brackett and Brenda J Smith

    Citation: Journal of Inflammation 2007 4:17

    Content type: Research

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  15. The Amazonian medicinal plant Sangre de grado (Croton palanostigma) has traditional applications for the treatment of wound healing and inflammation. We sought to characterize two extracts (progrado and zangrado)...

    Authors: Mark JS Miller, Paul Bobrowski, Meenakshi Shukla, Kalpana Gupta and Tariq M Haqqi

    Citation: Journal of Inflammation 2007 4:16

    Content type: Research

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  16. Recently it was shown that in Idiopathic Pulmonary Fibrosis (IPF) tissue infiltrating CD8+ T lymphocytes (TLs) are associated with breathlessness and physiological indices of disease severity, as well as that CD8...

    Authors: Spyros A Papiris, Androniki Kollintza, Marilena Karatza, Effrosyni D Manali, Christina Sotiropoulou, Joseph Milic-Emili, Charis Roussos and Zoe Daniil

    Citation: Journal of Inflammation 2007 4:14

    Content type: Review

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  17. The inflammation that accompanies the pain and swelling associated with osteo- and rheumatoid arthritis is mediated by complex interactions of inflammatory mediators. Cytokines play a pivotal role in orchestra...

    Authors: Nicola J Barton, David A Stevens, Jane P Hughes, Adriano G Rossi, Iain P Chessell, Alison J Reeve and Daniel S McQueen

    Citation: Journal of Inflammation 2007 4:13

    Content type: Research

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  18. Monocytes and neutrophils are examples of phagocytic leukocytes, with neutrophils being considered as the 'chief' phagocytic leukocyte. Both monocytes and neutrophils have been implicated to play a key role in...

    Authors: Stephen F Hughes, Beverly D Hendricks, David R Edwards, Salah S Bastawrous, Gareth E Roberts and Jim F Middleton

    Citation: Journal of Inflammation 2007 4:12

    Content type: Research

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  19. Neutrophil adhesion and migration are critical in hepatic ischemia and reperfusion injury (I/R). P-selectin and the intercellular adhesion molecule (ICAM)-1 can mediate neutrophil-endothelial cell interactions...

    Authors: Keith M Monson, Shadi Dowlatshahi and Elahé T Crockett

    Citation: Journal of Inflammation 2007 4:11

    Content type: Research

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  20. Since airway hyperresponsiveness (AHR) and allergic inflammatory changes are regarded as the primary manifestations of asthma, the main goals of asthma treatment are to decrease inflammation and maximize bronc...

    Authors: Min Min Zhu, Qin Hai Zhou, Mei Hua Zhu, Hai Bo Rong, Yu Ming Xu, Yan Ning Qian and Cheng Zhang Fu

    Citation: Journal of Inflammation 2007 4:10

    Content type: Research

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  21. Adenovirus and cationic liposome mediated transfer of Interleukin-10 (IL-10), a potent anti-inflammatory cytokine, has been shown to decrease pro-inflammatory cytokine levels and overall lung inflammation in m...

    Authors: John T Li, Laura L Bonneau, Jerry J Zimmerman and Daniel J Weiss

    Citation: Journal of Inflammation 2007 4:9

    Content type: Research

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  22. In a case-control study among 2064 South African women to investigate the risk of clinically invasive cancer of the cervix, we found a marked reduction in the risk of cervical cancer among women who gave a his...

    Authors: Jo-Ann S Passmore, Chelsea Morroni, Samual Shapiro, Anna-Lise Williamson and Margaret Hoffman

    Citation: Journal of Inflammation 2007 4:8

    Content type: Research

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  23. Over the last 10 years, whey proteins have received considerable attention in the area of functional foods and nutraceuticals. In this paper, a novel fermented whey protein-based product described as a gel-lik...

    Authors: Josée Beaulieu, Claude Dupont and Pierre Lemieux

    Citation: Journal of Inflammation 2007 4:6

    Content type: Research

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  24. The inflammatory process, orchestrated against a variety of injurious stimuli, is composed of three inter-related phases; initiation, propagation and resolution. Understanding the interplay between these three...

    Authors: Martin F Lister, John Sharkey, Deborah A Sawatzky, Joseph P Hodgkiss, Donald J Davidson, Adriano G Rossi and Keith Finlayson

    Citation: Journal of Inflammation 2007 4:5

    Content type: Review

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  25. Neonatal monocytes display immaturity of numerous functions compared with adult cells. Gene expression arrays provide a promising tool for elucidating mechanisms underlying neonatal immune function. We used a ...

    Authors: Shelley Lawrence, Yuhong Tang, M Barton Frank, Igor Dozmorov, Kaiyu Jiang, Yanmin Chen, Craig Cadwell, Sean Turner, Michael Centola and James N Jarvis

    Citation: Journal of Inflammation 2007 4:4

    Content type: Research

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  26. Cigarette smoking is a major cause of lung damage. One prominent deleterious effect of cigarette smoke is oxidative stress. Oxidative stress may lead to apoptosis and lung injury. Since black tea has antioxida...

    Authors: Shuvojit Banerjee, Palas Maity, Subhendu Mukherjee, Alok K Sil, Koustubh Panda, Dhrubajyoti Chattopadhyay and Indu B Chatterjee

    Citation: Journal of Inflammation 2007 4:3

    Content type: Research

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  27. Tristetraprolin (TTP/ZFP36) family proteins have anti-inflammatory activity by binding to and destabilizing pro-inflammatory mRNAs such as Tnf mRNA, and represent a potential therapeutic target for inflammatio...

    Authors: Heping Cao, Meghan A Kelly, Frank Kari, Harry D Dawson, Joseph F Urban Jr, Sara Coves, Anne M Roussel and Richard A Anderson

    Citation: Journal of Inflammation 2007 4:1

    Content type: Research

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  28. Serum sialic acid and C reactive protein are the markers for inflammation. The main objective of this study was to determine the sialic acid level in Caribbean type 2 diabetic patients with and without microva...

    Authors: B Shivananda Nayak and Lesley Roberts

    Citation: Journal of Inflammation 2006 3:17

    Content type: Research

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  29. The objective for this present study was to determine whether or not suspension bead array is a feasible method to detect changes in cytokine protein expression in mouse lung tissue homogenates. Here, we repor...

    Authors: Eric McDuffie, Leslie Obert, Jonathan Chupka and Robert Sigler

    Citation: Journal of Inflammation 2006 3:15

    Content type: Research

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  30. Cathelicidins are mammalian proteins containing a C-terminal cationic antimicrobial domain. Porcine PR-39 cathelicidin affects leukocyte biology. Mechanisms of action may involve alteration of heparan sulfate ...

    Authors: Angela Djanani, Birgit Mosheimer, Nicole C Kaneider, Christopher R Ross, Giovanni Ricevuti, Josef R Patsch and Christian J Wiedermann

    Citation: Journal of Inflammation 2006 3:14

    Content type: Short Report

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  31. Prostaglandin H2 synthase (PGHS) is the enzyme that catalyses the two-stage conversion of arachidonic acid to prostaglandin H2 (PGH2) prior to formation of prostanoids that are important in inflammation. PGHS iso...

    Authors: Catriona M Turnbull, Danny McClure, Adriano G Rossi and Ian L Megson

    Citation: Journal of Inflammation 2006 3:12

    Content type: Research

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  32. Glucocorticoids are used to treat chronic inflammatory diseases such as asthma. Induction of eosinophil apoptosis is considered to be one of the main mechanisms behind the anti-asthmatic effect of glucocortico...

    Authors: Mirkka Janka-Junttila, Eeva Moilanen, Hannele Hasala, Xianzhi Zhang, Ian Adcock and Hannu Kankaanranta

    Citation: Journal of Inflammation 2006 3:10

    Content type: Research

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  33. Yeast and bacteria elicit arachidonate release in macrophages, leading to the formation of leukotrienes and prostaglandins, important mediators of inflammation. Receptors recognising various microbes have been...

    Authors: Sandra Olsson and Roger Sundler

    Citation: Journal of Inflammation 2006 3:8

    Content type: Research

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  34. TGF-β plays an important role in the genesis and progression of pulmonary fibrosis. We sought to determine the role of mononuclear phagocytes in the activation of TGF-β and found that freshly isolated peripher...

    Authors: Frank J Lichtenberger III, Christine R Montague, Melissa Hunter, Gwyn Frambach and Clay B Marsh

    Citation: Journal of Inflammation 2006 3:7

    Content type: Research

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  35. Ion transport is essential for maintenance of transmembranous and transcellular electric potential, fluid transport and cellular volume. Disturbance of ion transport has been associated with cellular dysfuncti...

    Authors: Michael Eisenhut

    Citation: Journal of Inflammation 2006 3:5

    Content type: Review

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  36. [1, 2, 4] triazolo [4, 3-a][1, 8]naphthyridine derivatives (including NF161 and NF177) were tested for anti-inflammatory, analgesic and antipyretic properties and for their effects on spontaneous locomotor activi...

    Authors: Chiara Dianzani, Massimo Collino, Margherita Gallicchio, Mario Di Braccio, Giorgio Roma and Roberto Fantozzi

    Citation: Journal of Inflammation 2006 3:4

    Content type: Research

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  37. Pulmonary fibrosis is characterized by excessive deposition of extracellular matrix in the interstitium resulting in respiratory failure. The role of remodeling mediators such as metalloproteinases (MMPs) and ...

    Authors: Boris Manoury, Soazig Nenan, Isabelle Guenon, Elisabeth Boichot, Jean-Michel Planquois, Claude P Bertrand and Vincent Lagente

    Citation: Journal of Inflammation 2006 3:2

    Content type: Research

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  38. French maritime pine bark extract (Pycnogenol®) displays a variety of anti-inflammatory effects in vivo. Aim of this study was to determine whether human plasma after oral intake of Pycnogenol contains sufficient...

    Authors: Tanja Grimm, Zuzana Chovanová, Jana Muchová, Katarína Sumegová, Anna Liptáková, Zdeňka Ďuračková and Petra Högger

    Citation: Journal of Inflammation 2006 3:1

    Content type: Research

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  39. Bacterial and viral exacerbations play a crucial role in a variety of lung diseases including COPD or asthma. Since the lung epithelium is a major source of various inflammatory mediators that affect the immun...

    Authors: Mirko Ritter, Detlev Mennerich, Andreas Weith and Peter Seither

    Citation: Journal of Inflammation 2005 2:16

    Content type: Research

    Published on:

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