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  1. Intra-articular hyaluronan (HA) injection provides symptomatic benefit in the treatment of osteoarthritis (OA). Previously we found superior beneficial effects in a large animal OA model of a hexadecylamide de...

    Authors: Margaret M Smith, Amy K Russell, Antonella Schiavinato and Christopher B Little
    Citation: Journal of Inflammation 2013 10:26
    Content type: Research Published on:

  2. Ovarian cancer, an inflammation-associated cancer, is the fifth leading cause of cancer deaths in women. The malignancy produces a large amount of tumor necrosis factor (TNF) which promotes a proinflammatory t...

    Authors: Deok-Soo Son, Syeda M Kabir, Yuanlin Dong, Eunsook Lee and Samuel E Adunyah
    Citation: Journal of Inflammation 2013 10:25
    Content type: Research Published on:

  3. Prolactin from pituitary gland helps maintain homeostasis but it is also released in immune cells where its function is not completely understood. Pleiotropic functions of prolactin (PRL) might be mediated by ...

    Authors: Gonzalo López-Rincón, Ana L Pereira-Suárez, Susana Del Toro-Arreola, Pedro E Sánchez-Hernández, Alejandra Ochoa-Zarzosa, José Francisco Muñoz-Valle and Ciro Estrada-Chávez
    Citation: Journal of Inflammation 2013 10:24
    Content type: Research Published on:

  4. The extracellular matrix plays a critical role in insuring tissue integrity and water homeostasis. However, breakdown products of the extracellular matrix have emerged as endogenous danger signals, designed to...

    Authors: Katharine E Black, Samuel L Collins, Robert S Hagan, Mark J Hamblin, Yee Chan-Li, Robert W Hallowell, Jonathan D Powell and Maureen R Horton
    Citation: Journal of Inflammation 2013 10:23
    Content type: Research Published on:

  5. Chronic spontaneous urticaria (CU) is associated with activation of the acute phase response (APR). Nevertheless, APR-associated proteins have not been well characterized as potential biomarkers of the disease...

    Authors: Alicja Kasperska-Zajac, Alicja Grzanka, Edyta Machura, Maciej Misiolek, Bogdan Mazur and Jerzy Jochem
    Citation: Journal of Inflammation 2013 10:22
    Content type: Short Report Published on:

  6. CD4+ T cell activation indicators have been reported to be a common phenomenon underlying diverse manifestations of immune reconstitution inflammatory syndrome (IRIS). However, we have found that a high frequency...

    Authors: Enrique Espinosa, Dámaris P Romero-Rodríguez, María-Teresa Cantoral-Díaz and Gustavo Reyes-Terán
    Citation: Journal of Inflammation 2013 10:21
    Content type: Research Published on:

  7. Although various microRNAs (miRNAs) regulate immune and inflammatory responses, the function of miRNAs in periodontitis has not been clearly illuminated. In this study, we measured miRNA-146 (miRNA-146a and mi...

    Authors: Yu-Feng Xie, Rong Shu, Shao-Yun Jiang, Da-Li Liu, Jing Ni and Xiu-Li Zhang
    Citation: Journal of Inflammation 2013 10:20
    Content type: Research Published on:

  8. Airway inflammation and asthma have been linked to oxidative stress and the melastatin-related transient receptor potential cation channel, member 2 (TRPM2), which can be activated by reactive oxygen species (...

    Authors: Adriana Sumoza-Toledo, Andrea Fleig and Reinhold Penner
    Citation: Journal of Inflammation 2013 10:19
    Content type: Research Published on:

  9. The aim of this study was to identify transcription factors/regulators that play a crucial role in steering the (innate) immune response shortly (within a few hours) after the first contact of the intestinal m...

    Authors: Marcel Hulst, Mari Smits, Stéphanie Vastenhouw, Agnes de Wit, Theo Niewold and Jan van der Meulen
    Citation: Journal of Inflammation 2013 10:18
    Content type: Research Published on:

  10. TLR-2 is expressed on the surface of leucocytes, lung and liver tissue and initiates the activation of immune response after interaction with components of the bacterial cell wall. In this experiment we invest...

    Authors: Roman Pfeifer, Thomas Tschernig, Philipp Lichte, Derek Dombroski, Philipp Kobbe and Hans-Christoph Pape
    Citation: Journal of Inflammation 2013 10:17
    Content type: Research Published on:

  11. Interleukin 1 beta (IL-1β) contributes to the development of inflammatory bowel disease (IBD) and is correlated with the severity of intestinal inflammation. However, the precise source of IL-1β producing cell...

    Authors: Limei Li, Zhenzhe Liu, Xinyu Yang, Huimin Yan, Shisan Bao and Jian Fei
    Citation: Journal of Inflammation 2013 10:16
    Content type: Research Published on:

  12. HDAC inhibitors have been proposed as anticancer agents. However, their roles in innate genes expression remain not well known. Cathelicidin LL-37 is one of the few human bactericidal peptides, but the regulat...

    Authors: Quan Liu, Juan Liu, Kristina Irene Lisolette Roschmann, Danielle van Egmond, Korneliusz Golebski, Wytske Johanna Fokkens, Dehui Wang and Cornelis Maria van Drunen
    Citation: Journal of Inflammation 2013 10:15
    Content type: Research Published on:

  13. Pathogens that establish chronic infection elicit immune responses with suppressive cytokines dominating over pro-inflammatory cytokines. Chronic hepatitis C virus (HCV) infection, human immunodeficiency virus...

    Authors: Tigran K Davtyan, David A Poghosyan, Anna G Sukiasyan and Michael D Grant
    Citation: Journal of Inflammation 2013 10:14
    Content type: Research Published on:

  14. Obstructive sleep apnea (OSA) is associated with coronary artery disease (CAD). Intermittent hypoxia associated with OSA increases sympathetic activity and may cause systemic inflammation, which may contribute...

    Authors: Aaron Baessler, Rashid Nadeem, Michael Harvey, Essam Madbouly, Amna Younus, Hassan Sajid, Jawed Naseem, Asma Asif and Hasnain Bawaadam
    Citation: Journal of Inflammation 2013 10:13
    Content type: Research Published on:

  15. Activation of NADPH oxidase is required for neutrophil extracellular trap (NET) formation. Protein kinase C (PKC) is an upstream mediator of NADPH oxidase activation and thus likely to have a role in NET forma...

    Authors: Robert D Gray, Christopher D Lucas, Annie MacKellar, Feng Li, Katia Hiersemenzel, Chris Haslett, Donald J Davidson and Adriano G Rossi
    Citation: Journal of Inflammation 2013 10:12
    Content type: Short Report Published on:

  16. To analyze the expression at basal level of inflammation-related cytokines and chemokines and the activation status of the NF-κB pathway, together with the proliferation and apoptosis indexes in two widely use...

    Authors: Ida Silvestri, Susanna Cattarino, AnnaMaria Aglianò, Chiara Nicolazzo, Susanna Scarpa, Stefano Salciccia, Luigi Frati, Vincenzo Gentile and Alessandro Sciarra
    Citation: Journal of Inflammation 2013 10:11
    Content type: Research Published on:

  17. Intestinal ischemia/reperfusion (IR) injury is a serious and triggering event in the development of remote organ dysfunction, from which the lung is the main target. This condition is characterized by intense ...

    Authors: Bruna Candido Guido, Marianna Zanatelli, Wothan Tavares-de-Lima, Sonia Maria Oliani and Amílcar Sabino Damazo
    Citation: Journal of Inflammation 2013 10:10
    Content type: Research Published on:

  18. Acute hemorrhagic necrotizing pancreatitis (AHNP) is a severe acute inflammatory of pancreas that can lead to extrapancreatic organ disfunction. The lung and intestine is the most common involved organs, and a...

    Authors: He Peng, Wang Zhi-fen, Jin Su-mei, Guo Yun-zhen, Li Yan and Chen Li-ping
    Citation: Journal of Inflammation 2013 10:9
    Content type: Research Published on:

  20. The objective of this study was to identify biomarkers of sepsis-induced disseminated intravascular coagulation (DIC) among platelet-derived factors using biotin label-based custom protein microarray technolog...

    Authors: Jingchun Song, Dunzhong Hu, Chao He, Tao Wang, Xuefeng Liu, Linhao Ma, Zhaofen Lin and Zili Chen
    Citation: Journal of Inflammation 2013 10:7
    Content type: Research Published on:

  21. Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are characterized by a disruption of the endothelium and alveolar epithelial barriers involving increased microvascular permeability, thus...

    Authors: Takeshi Wada, Subrina Jesmin, Satoshi Gando, Yuichiro Yanagida, Asumi Mizugaki, Sayeeda Nusrat Sultana, Sohel Zaedi and Hiroyuki Yokota
    Citation: Journal of Inflammation 2013 10:6
    Content type: Research Published on:

  22. Obesity and serum C-reactive protein (CRP) (a sensitive marker of inflammatory activity) are associated with most chronic diseases. Abdominal adiposity along with age is the strongest determinant of baseline C...

    Authors: Sashidhar Irkulla, Bedri Ujam, David Gaze, Devinder Kumar and Michael A Mendall
    Citation: Journal of Inflammation 2013 10:5
    Content type: Research Published on:

  23. Eosinophils are often predominant inflammatory leukocytes infiltrating oral squamous carcinoma (OSC) sites. Prostaglandins are secreted by oral carcinomas and may be involved in eosinophil infiltration. The ob...

    Authors: Francis Davoine, Adrian Sim, Charlie Tang, Sibina Fisher, Caroline Ethier, Lakshmi Puttagunta, Yingqi Wu, W Tim McGaw, Donald Yu, Lisa Cameron, Darryl J Adamko and Redwan Moqbel
    Citation: Journal of Inflammation 2013 10:4
    Content type: Research Published on:

  24. Little is known about the time-course of the postprandial appearance of macronutrient-induced inflammatory response. Our aim was to investigate the postprandial inflammatory and metabolic response following hi...

    Authors: Olga Raz, Arie Steinvil, Shlomo Berliner, Tovit Rosenzweig, Dan Justo and Itzhak Shapira
    Citation: Journal of Inflammation 2013 10:3
    Content type: Research Published on:

  25. Surfactant protein A (SP-A), encoded by two functional genes, SP-A1 and SP-A2, is essential for the inflammatory process and host defence in the lungs. Recent studies have demonstrated the extrapulmonary expre...

    Authors: Jiao Liu, Fengqi Hu, Guirong Wang, Qingshan Zhou and Guohua Ding
    Citation: Journal of Inflammation 2013 10:2
    Content type: Research Published on:

  26. XH-14 isolated from Salvia miltiorrhiza is a bioactive component and adenosine antagonist. In the present study, we evaluated anti-inflammatory properties of XH-14 in murine macrophages.

    Authors: Geun-Mook Park, Jong-Gab Jun and Jin-Kyung Kim
    Citation: Journal of Inflammation 2013 10:1
    Content type: Research Published on:

  27. During inflammation, the inflammasomes representing a group of multi-protein complexes trigger the biological maturation of pro-inflammatory cytokines such as interleukin-1β and interleukin-18 by proteolytic a...

    Authors: Sorina Georgiana Boaru, Erawan Borkham-Kamphorst, Lidia Tihaa, Ute Haas and Ralf Weiskirchen
    Citation: Journal of Inflammation 2012 9:49
    Content type: Research Published on:

  28. Expression profile of the toll like receptors (TLRs) on PBMCs is central to the regulation of proinflammatory markers. An imbalance in the TLRs expression may lead to several types of inflammatory disorders. F...

    Authors: Rasheed Ahmad, Anfal Al-Mass, Valerie Atizado, Asma Al-Hubail, Fahad Al-Ghimlas, Monira Al-Arouj, Abdullah Bennakhi, Said Dermime and Kazem Behbehani
    Citation: Journal of Inflammation 2012 9:48
    Content type: Research Published on:

  29. It is well known that nitric oxide (NO) is generated by a family of constitutively (nNOS and eNOS) or inducibly (iNOS) expressed enzymes and takes part in different aspects of the inflammatory response; nevert...

    Authors: Chiara Bernardini, Francesca Greco, Augusta Zannoni, Maria Laura Bacci, Eraldo Seren and Monica Forni
    Citation: Journal of Inflammation 2012 9:47
    Content type: Research Published on:

  30. Squamous cell carcinoma (SCC) is one of the most common human cancers worldwide. In SCC, tumour development is accompanied by an immune response that leads to massive tumour infiltration by inflammatory cells,...

    Authors: Thais Helena Gasparoto, Carine Ervolino de Oliveira, Luisa Thomazini de Freitas, Claudia Ramos Pinheiro, Rodrigo Nalio Ramos, André Luis da Silva, Gustavo Pompermaier Garlet, João Santana da Silva and Ana Paula Campanelli
    Citation: Journal of Inflammation 2012 9:46
    Content type: Research Published on:

  31. Smoking is known to be associated with oxidative stress; however, it has not been elucidated whether the oxidative response is influenced by the intensity of smoking exposure.

    Authors: Suzana E Tanni, Camila R Correa, Aparecida Y Angeleli, Simone A Vale, Liana S Coelho and Irma Godoy
    Citation: Journal of Inflammation 2012 9:45
    Content type: Research Published on:

  32. Cyclophilin A (CypA), a member of the immunophilin family, is a ubiquitously distributed intracellular protein. Recent studies have shown that CypA is secreted by cells in response to inflammatory stimuli. Ele...

    Authors: Tsuyoshi Nishioku, Shinya Dohgu, Mitsuhisa Koga, Takashi Machida, Takuya Watanabe, Teppei Miura, Kousuke Tsumagari, Mariko Terasawa, Atsushi Yamauchi and Yasufumi Kataoka
    Citation: Journal of Inflammation 2012 9:44
    Content type: Short Report Published on:

  33. Gold salts has previously been used in the treatment of rheumatoid arthritis but have been replaced by biologicals such as TNF-α inhibitors. The mechanisms behind the anti-inflammatory effect of metallic gold ...

    Authors: Oliver Seifert, Andreas Matussek, Florence Sjögren, Robert Geffers and Chris D Anderson
    Citation: Journal of Inflammation 2012 9:43
    Content type: Research Published on:

  34. C-reactive protein (CRP) and lysophosphatidylcholine (LPC) are phosphorylcholine-(PC)-containing oxidized phospholipids (oxPLs) found in oxidized LDL (oxLDL), which trigger pro-atherogenic activities of macrop...

    Authors: Mi-Kyung Chang, Karsten Hartvigsen, Jewon Ryu, Yuna Kim and Ki Hoon Han
    Citation: Journal of Inflammation 2012 9:42
    Content type: Research Published on:

  35. Dianthus superbus has long been used as a herbal medicine in Asia and as an anti-inflammatory agent. In this study, we evaluated the anti-inflammatory effects of Dianthus superbus fructus ethanolic extract (DSE) ...

    Authors: In-Sik Shin, Mee-Young Lee, Hyekyung Ha, Woo-Young Jeon, Chang-Seob Seo and Hyeun-Kyoo Shin
    Citation: Journal of Inflammation 2012 9:41
    Content type: Research Published on:

  36. The purpose of this study was to determine the reaction mechanism of corticosteroid by analyzing the expression patterns of neuropeptides (substance P (SP), calcitonin gene related peptide (CGRP)) and of cytok...

    Authors: Soo Hong Han, Hee Jung An, Ji Ye Song, Dong Eun Shin, Young Do Kwon, Jong Sup Shim and Soon Chul Lee
    Citation: Journal of Inflammation 2012 9:40
    Content type: Research Published on:

  37. Interleukin-7 (IL-7) acts primarily on T cells to promote their differentiation, survival, and homeostasis. Under disease conditions, IL-7 mediates inflammation through several mechanisms and cell types. In hu...

    Authors: Cynthia R Willis, Audrey Seamons, Joe Maxwell, Piper M Treuting, Laurel Nelson, Guang Chen, Susan Phelps, Carole L Smith, Thea Brabb, Brian M Iritani and Lillian Maggio-Price
    Citation: Journal of Inflammation 2012 9:39
    Content type: Research Published on:

  38. Three subpopulations of monocytes can be distinguished in human blood: classical (CD14++CD16−), intermediate (CD14++CD16+), and nonclassical (CD14+CD16++). CD16 expressing monocytes are expanded in patients with ...

    Authors: Daniëlle Hijdra, Adriane DM Vorselaars, Jan C Grutters, Anke ME Claessen and Ger T Rijkers
    Citation: Journal of Inflammation 2012 9:38
    Content type: Research Published on:

  40. Glutathione (GSH)/glutathione disulfide (GSSG) and cysteine (Cys)/cystine (CySS) are major redox pools with important roles in cytoprotection. We determined the impact of septic peritonitis on thiol-disulfide ...

    Authors: Shana M Benton, Zhe Liang, Li Hao, Youngliang Liang, Gautam Hebbar, Dean P Jones, Craig M Coopersmith and Thomas R Ziegler
    Citation: Journal of Inflammation 2012 9:36
    Content type: Research Published on:

  41. Obesity is a state of subclinical inflammation resulting in loss of function of insulin receptors and decreased insulin sensitivity. Inhibition of the inflammatory enzymes, matrix metalloproteinases (MMPs), fo...

    Authors: Karen Frankwich, Courtney Tibble, Moises Torres-Gonzalez, Mariah Bonner, Roy Lefkowitz, Matt Tyndall, Geert W Schmid-Schönbein, Francisco Villarreal, Mike Heller and Karen Herbst
    Citation: Journal of Inflammation 2012 9:35
    Content type: Research Published on:

  42. Hemorrhagic shock results in systemic activation of the immune system and leads to ischemia-reperfusion injury. Lymphocytes have been identified as critical mediators of the early innate immune response to isc...

    Authors: Jason S Hawksworth, Christopher Graybill, Trevor S Brown, Suzanne M Gillern, Shannon M Wallace, Thomas A Davis, Eric A Elster and Doug K Tadaki
    Citation: Journal of Inflammation 2012 9:34
    Content type: Research Published on:

  43. Mesenchymal stem cells (MSCs) possess potent immunomodulatory properties and simultaneously lack the ability to illicit immune responses. Hence, MSCs have emerged as a promising candidate for cellular therapeu...

    Authors: Jianjun Li, Dong Li, Xiaomei Liu, Shuhai Tang and Fengcai Wei
    Citation: Journal of Inflammation 2012 9:33
    Content type: Research Published on:

  44. Serine proteases in German cockroach (GC) have been shown to mediate allergic airway inflammation through the activation of protease activated receptor (PAR)-2. Neutrophils play an important role in regulating...

    Authors: Riad Lutfi, Ian P Lewkowich, Ping Zhou, John R Ledford and Kristen Page
    Citation: Journal of Inflammation 2012 9:32
    Content type: Research Published on:

  45. Tetracyclines are broad-spectrum antibiotics that are also used to induce gene expression using the reverse tetracycline transactivator / tetracycline operator system (rtTA/tetO system). The system assumes tha...

    Authors: Andres Moon, Sucheol Gil, Sean E Gill, Peter Chen and Gustavo Matute-Bello
    Citation: Journal of Inflammation 2012 9:31
    Content type: Research Published on:

  46. Inflammatory bowel diseases are associated with increased adiponectin (APN) levels, which may exert pro-inflammatory effects in these individuals. Since habitual exercise may increase APN, the aim of this stud...

    Authors: Arpit Saxena, Emma Fletcher, Bianca Larsen, Manjeshwar Shrinath Baliga, J Larry Durstine and Raja Fayad
    Citation: Journal of Inflammation 2012 9:30
    Content type: Research Published on:

  47. As proinflammatory cytokines seem to play a role in discogenic back pain, substances exhibiting anti-inflammatory effects on intervertebral disc cells may be used as minimal-invasive therapeutics for intradisc...

    Authors: Marina Klawitter, Lilian Quero, Juergen Klasen, Alexia N Gloess, Babette Klopprogge, Oliver Hausmann, Norbert Boos and Karin Wuertz
    Citation: Journal of Inflammation 2012 9:29
    Content type: Research Published on:

  49. Idiopathic Pulmonary Fibrosis and Rheumatoid Arthritis associated usual interstitial pneumonia seem to have the same poor outcome as there is not an effective treatment. The aim of the study is to explore the ...

    Authors: Katerina M Antoniou, George A Margaritopoulos, Athanasia Proklou, Konstantinos Karagiannis, Ismini Lasithiotaki, Giannoula Soufla, Maria Christina Kastrinaki, Demetrios A Spandidos, Helen A Papadaki and Nikos M Siafakas
    Citation: Journal of Inflammation 2012 9:27
    Content type: Research Published on:

  50. Persistent vascular inflammation has been implicated as an important cause for a higher prevalence of cardiovascular disease (CVD) in HIV-infected adults. In several populations at high risk for CVD, vascular 18F...

    Authors: Kevin E Yarasheski, Erin Laciny, E Turner Overton, Dominic N Reeds, Michael Harrod, Steven Baldwin and Victor G Dávila-Román
    Citation: Journal of Inflammation 2012 9:26
    Content type: Research Published on:

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Journal of Inflammation

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