Fig. 5From: Neutrophil extracellular traps in acute coronary syndromeSchematic illustration of molecular mechanisms of neutrophil extracellular traps (NETs) in heart failure. Midkine has a significant regulatory effect on NETs. It can promote the formation of NETs in vitro, inhibit the formation of NETs and reduce the infiltration of neutrophils in vivo. Furthermore, NETs induce myocardial fibrosis and cause cardiac systolic or diastolic dysfunction, which is manifested as systolic or diastolic heart failureBack to article page