Fig. 2

Ferris Wheel Plot. Ferris Wheel Plot summarizing the identified EC markers in SLE per category of dominant EC dysfunction of each EC marker. The surface area of each EC marker represents the number of articles with EC marker data on the corresponding dysfunction. The EC marker with the highest number of articles in which the EC marker was reported as dysregulated, can be recognized by the darkened background color and white text). EC = endothelial cell, DV = disturbed vasculogenesis, DVT = defective vascular tone control, M = mixed (adipocytokines and EC apoptosis). Markers in Ferris Wheel Plot: ADAMTS13: A Disintegrin-like and Metalloprotease with Thrombospondin Type 1 Motif Adipo: Adiponectin AM: Adrenomedullin Ang-1: Angiopoietin-1 Ang-2: Angiopoietin-2 bFGF: basic fibroblast growth factor Endoglin Endostatin EPCR: Endothelial protein C receptor E-Selectin ET-1: Endothelin-1 FasL: Fas ligand GAS6: growth arrest-specific gene 6 HGF: Hepatocyte growth factor ICAM-1: Intercellular Adhesion Molecule 1 IP-10: interferon-inducible protein 10 L-Selectin MCP-1: Monocyte chemoattractant protein-1 Neopterin PAI-1: Plasminogen activator inhibitor-1 PECAM-1: Platelet and endothelial cell adhesion molecule 1 PlGF: Placental growth factor P-Selectin PTX3: Pentraxin-3 sEPCR: Soluble endothelial protein C receptor Tie2: Tyrosine kinase with immunoglobulin-like and EGF-like domain 2 TM: Thrombomodulin VCAM-1: Vascular Cell Adhesion Molecule 1 VEGF: Vascular Endothelial Growth-Factor VWF: Von Willebrand Factor TWEAK: Tumor necrosis factor (TNF)-like weak inducer of apoptosis