Fig. 3
From: Dioscin alleviates the progression of osteoarthritis: an in vitro and in vivo study
Dio inhibits IL-1β-induced upregulation of MMPs and ADAMTS-5. Chondrocytes were exposed to IL-1β (10 ng/mL) with or without Dio (200, 400, and 800 ng/mL) for 24 h. A Gene expressions of MMP1, MMP3, MMP13, and ADAMTS-5 were detected by qRT-PCR. B Representative western blots and (C) quantitative analysis of MMP1, MMP3, MMP13, and ADAMTS-5 in each group. #P < 0.05 vs. control group; *P < 0.05 vs. IL-1β group; **P < 0.01 vs. IL-1β group; n = 3