Anti-inflammatory activity of non-selective PDE inhibitor aminophylline on the lung tissue and respiratory parameters in animal model of ARDS

Kosutova, Petra; Mikolka, Pavol; Mokra, Daniela; Calkovska, Andrea

doi:10.1186/s12950-023-00337-y

Table 1 Respiratory parameters. Mean airway pressure (MAP, kPa), static lung compliance (C_stat, mL/kPa) airway resistance (Raw, kPa/L/s), arterial partial carbon dioxide pressure (PaCO₂, kPa) oxygen saturation (SatO₂, %) and pH before (basal value, BV), after ARDS induction and within 4 h after the therapy administration in the Control group (n = 8), ARDS group (n = 8), and ARDS group treated with aminophylline (ARDS/AMINO; n = 8). Data are presented as mean ± SD. Statistical comparisons: for ARDS vs. Control p < 0.05, p < 0.01, p < 0.001, **** p < 0.0001; for ARDS/AMINO vs. ARDS ⁺p < 0.05, ⁺⁺p < 0.01, ⁺⁺⁺p < 0.001; ⁺⁺⁺⁺p < 0.0001

From: Anti-inflammatory activity of non-selective PDE inhibitor aminophylline on the lung tissue and respiratory parameters in animal model of ARDS

	BV	Model	30' Th	1 h Th	2 h Th	3 h Th	4 h Th
MAP (kPa)
Control	0.76 ± 0.06	0.88 ± 0.13	0.86 ± 0.14	0.86 ± 0.16	0.84 ± 0.19	0.85 ± 0.18	0.87 ± 0.19
ARDS	0.79 ± 0.08	1.09 ± 0.09 *	1.01 ± 0.13	1.02 ± 0.14	1.06 ± 0.17 *	1.02 ± 0.16	1.06 ± 0.17 *
ARDS/AMINO	0.80 ± 0.05	0.90 ± 0.14	0.90 ± 0.12	0.91 ± 0.19	0.94 ± 0.15	0.92 ± 0.14	0.87 ± 0.11 ⁺
C_stat (mL/kPa)
Control	0.016 ± 0.002	0.016 ± 0.002	0.016 ± 0.002	0.017 ± 0.001	0.017 ± 0.001	0.017 ± 0.001	0.016 ± 0.002
ARDS	0.013 ± 0.003	0.008 ± 0.001 ****	0.009 ± 0.002 ****	0.008 ± 0.002 ****	0.009 ± 0.002 ****	0.009 ± 0.002 ****	0.008 ± 0.001 ****
ARDS/AMINO	0.016 ± 0.002	0.011 ± 0.002	0.011 ± 0.004	0.012 ± 0.003 ⁺⁺	0.011 ± 0.003	0.011 ± 0.002	0.011 ± 0.003 ⁺
Raw (kPa/L/s)
Control	4.51 ± 0.79	4.62 ± 0.91	4.94 ± 1.02	4.44 ± 0.83	4.70 ± 0.77	4.51 ± 0.66	4.61 ± 0.80
ARDS	4.29 ± 1.95	12.55 ± 4.03 ****	14.70 ± 5.06 ****	15.22 ± 5.18 ****	14.45 ± 5.37 ****	15.14 ± 5.56 ****	17.38 ± 6.41 ^****
ARDS/AMINO	4.72 ± 0.89	10.17 ± 6.43	8.36 ± 3.84 ⁺⁺⁺	8.69 ± 4.57 ⁺⁺⁺	10.18 ± 4.38 ⁺	9.90 ± 4.80 ⁺⁺	9.74 ± 4.97 ⁺⁺⁺⁺
PaCO₂ (kPa)
Control	4.39 ± 0.67	4.54 ± 0.63	4.34 ± 0.58	4.29 ± 0.56	4.08 ± 0.64	4.04 ± 0.57	4.00 ± 0.70
ARDS	3.67 ± 0.86	6.76 ± 1.35 ****	6.56 ± 1.51 ****	6.50 ± 1.34 ****	6.06 ± 1.59 ****	6.19 ± 1.69 ****	6.28 ± 1.92 ****
ARDS/AMINO	4.22 ± 0.43	6.07 ± 1.24	6.01 ± 1.31	6.01 ± 1.20	5.55 ± 1.32	5.39 ± 1.31	5.10 ± 1.18 ⁺
SatO₂ (%)
Control	99.90 ± 0.00	99.89 ± 0.03	99.90 ± 0.00	99.89 ± 0.03	99.89 ± 0.03	99.89 ± 0.03	99.89 ± 0.03
ARDS	99.89 ± 0.04	95.56 ± 2.43 **	94.13 ± 1.44 **	91.03 ± 13.19 ****	92.11 ± 8.96 ****	94.37 ± 3.57 ****	93.44 ± 4.06 ****
ARDS/AMINO	99.90 ± 0.00	97.96 ± 1.72	98.33 ± 1.29 ⁺	98.05 ± 1.72 ⁺⁺⁺⁺	98.73 ± 1.36 ⁺⁺⁺⁺	99.24 ± 0.99 ⁺⁺	99.44 ± 0.67 ⁺⁺⁺⁺
pH
Control	7.49 ± 0.07	7.46 ± 0.09	7.41 ± 0.05	7.37 ± 0.03	7.32 ± 0.05	7.27 ± 0.06	7.24 ± 0.05
ARDS	7.54 ± 0.06	7.22 ± 0.07 ****	7.21 ± 0.08 ****	7.19 ± 0.09 ****	7.15 ± 0.10 ****	7.10 ± 0.11 ****	7.03 ± 0.11 ****
ARDS/AMINO	7.50 ± 0.07	7.27 ± 0.10	7.23 ± 0.08	7.22 ± 0.07	7.19 ± 0.07	7.18 ± 0.06 ⁺	7.16 ± 0.07 ⁺⁺⁺

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