Fig. 2

Concentrations of inflammatory cytokines (A) IL-8, (B) IL-6, (C) TNFα, (D) IL-11β, (E) IL-10, (F) IL-13, (G) IL-18, (H) RAGE (all expressed in pg/mL), (I) S1P (expressed in ng/mL), (J) nitrite/nitrate and (K) nitrite (expressed in NOx micromolar concentration of NOx) in the lung tissue homogenates of healthy ventilated animals (Control; n = 8), ARDS animals (n = 8) and ARDS animals treated with aminophylline (ARDS/AMINO; n = 8) after 4 h of therapy. Data are presented as mean ± SD. Statistical comparisons: for ARDS vs. Control *p < 0.05, **p < 0.01, ***p < 0.001; for ARDS/AMINO vs. ARDS ⁺p < 0.05, ⁺⁺p < 0.01, ⁺⁺⁺p < 0.001; ⁺⁺⁺⁺p < 0.0001