Fig. 6

Modulation of intra- and extracellular catecholamine levels and IL-6 production by TNF. a-f Intracellular (a-c) and extracellular (d-f) levels of dopamine (DA) (a, d), norepinephrine (NE) (b, e) and epinephrine (EPI) (c, f) levels under basal conditions and after stimulation with TNF (10 ng/mL for 24 h. (n = 4–5) g IL-6 production in 24 h after stimulation with TNF vs unstimulated controls (n = 3). * p < 0.05, ** p < 0.01, for comparisons of catecholamine levels versus control by unpaired t-test in a-f, for the comparison of IL-6 production versus control MANN-Whitney U test was employed. Ctl (black), control group; TNF (red), tumor necrosis factor