Fig. 2
Deletion of TRPM2 reduces calcium influx and ROS production in MSU crystals-treated neutrophils. A Representative display of the dynamic changes of [Ca2+]i in WT and TRPM2−/− neutrophils within 60 min after exposure to MSU crystals. Mean ± SD is displayed. The p values at 20-60 min are <0.0001. B Representative display of the ROS production in WT and TRPM2−/− mice neutrophils within 340 min after exposure to MSU crystals. Mean ± SEM is displayed. The p values at 60 min to 340 min are 0.0160, 0.0071, 0.0032, 0.0038, 0.0032, 0.0026, 0.0021, 0.0016, 0.0021, 0.0017, 0.0013, 0.0011, 0.0013, 0.0012 and 0.0013, respectively