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Fig. 3 | Journal of Inflammation

Fig. 3

From: Disulfiram alleviates acute lung injury and related intestinal mucosal barrier impairment by targeting GSDMD-dependent pyroptosis

Fig. 3

GSDMD was required for ALI-induced intestinal barrier damage. (A) H&E staining images of intestinal mucosa tissues from WT and Gsdmd−/− groups mice with or without LPS treatment, under x200 magnification (scale bar = 100 μm); (B) The protein levels of ZO-1 and Occludin in intestinal mucosa tissues from indicated mice were determined by immunofluorescence histochemistry under x200 magnification (scale bar = 100 μm); The alveolar-capillary permeability by measuring(C) DAO and (D) D-lactic acid concentration. ***P < 0.001, by one-way ANOVA followed by post hoc Newman-Keuls Multiple Comparison Test

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