Fig. 2

GSDMD on LPS-induced pyroptosis is required in ALI. (A) H&E staining of lung sections from WT and Gsdmd^−/− groups mice with or without LPS administration under x200 magnification (scale bar = 100 μm);(B) wet/dry Ratio of the lung, ***P < 0.001, by one-way ANOVA followed by post hoc Newman-Keuls Multiple Comparison Test; (C) Levels of the number of total cells, macrophages, and neutrophils in BALF, ***P < 0.001, by two-way ANOVA followed by post hoc Bonferroni’s Multiple Comparison Test ; (D) Expression of IL-6 and TNF-α in serum, ***P < 0.001, by one-way ANOVA followed by post hoc Newman-Keuls Multiple Comparison Test n = 10 for per group. All data are median values from 3 independent experiments. NS means Not significant