Table 1 To summarize the mechanism of IL-17 in different diseases

Aortic dissection

Reduced endothelial progenitor cells partly related to upregulated IL-6/IL-17 through DiI-acLDL/lectin and CD34⁺KDR⁺ cells

[161]

Cardiovascular diseases with (dyslipidemia, hypertension and diabetes mellitus)

Enhancement of IL-17 /IFN-γ production of CD4⁺28^nullNKG2D⁺ T cells

[162]

Type 2 Diabetes Mellitus

IL-10/IL-17 correlated negatively with BMI or metabolic index

[163]

Preeclampsia

Mediated placental ischaemia and oxidative stress though AT1-AA production

[164, 165]

Idiopathic pulmonary arterial hypertension

TH17 cell immune polarization and IL-17A with disease severity or outcome associated conditions

[166, 167]

Systemic sclerosis

Activation of Th17 and Th1 cell responses

[168]

Schistosomiasis japonica

Activation of γδT cells and producing IL-17 against parasite eggs

[169]