Fig. 5

Interaction between clusters of different epithelial cell types after SARS-CoV-2 infection. A The pseudo-time trajectory of epithelial cell clusters 1, 2, 3, 4, 5, 6, and 7. Color from dark to light, indicating the differentiation time from early to late. B Pseudo-time trajectory of cell population differentiation in epithelial cell clusters 1–7. C Similarity heat map between clusters 1–7. Similarity heat map between clusters 1–7. Red represents high similarity, and blue represents low similarity. D Fifty marker genes of clusters 1–7 were selected for heat mapping display. E UpSet diagram of the differentially expressed genes in clusters 1, 3, 7, 2, and 6. F KEGG signaling pathway analysis of up-regulated differential genes in epithelial cell cluster 2. G KEGG signaling pathway analysis of down-regulated differential genes in epithelial cell cluster 2. H Heat map of cell death gene expression module in epithelial cell clusters 1–7