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Fig. 6 | Journal of Inflammation

Fig. 6

From: Human monocytes differentiate into tumor-associated macrophages upon SKOV3 cells coculture and/or lysophosphatidic acid stimulation

Fig. 6

The cytokine IL-6sR and JAK-STAT signaling pathway played an important role in the differentiation of monocytes into TAMs. A, B IL-6sR was significantly elevated in the 3 treatment groups (LPA5, SM and SM5) compared to the MO group. C, D, E, F GO enrichment analysis: the main molecular functions involved were cytokine activity and growth factor receptor binding and that the main biological processes involved were positive regulation of the STAT cascade and positive regulation of the JAK-STAT cascade. G KEGG pathway enrichment analysis: enrichment of the JAK-STAT signaling pathway and inflammatory bowel disease pathway

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