Fig. 2

Serinc2 KO enhances CLP-induced hyperactivation of inflammation. A Impact of Serinc2 KO on CLP-induced expression of IL1β, IL6, TNFα, and MCP1 measured by qRT-PCR. *P < 0.05, **P < 0.01, ***P < 0.001 vs. WT; #P < 0.05, ##P < 0.01, ###P < 0.001 vs. sham. n = 5–7. B Impact of Serinc2 KO on CLP-induced secretion of IL6 and TNFα in serum assessed by ELISA kits. *P < 0.05, ***P < 0.001 vs. WT; ###P < 0.001 vs. sham. n = 5–7. C Immunoblots of phosphorylated and total STAT3, p38, and ERK in the lung tissues from WT and Serinc2-KO mice with sham or CLP surgeries. D Quantification of STAT3, p38 and ERK phosphorylation levels in ratio to their total protein. *P < 0.05, **P < 0.01 vs. WT; #P < 0.05, ##P < 0.01, ###P < 0.001 vs. sham. n = 3