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Fig. 4 | Journal of Inflammation

Fig. 4

From: Cigarette smoke extract-mediated FABP4 upregulation suppresses viability and induces apoptosis, inflammation and oxidative stress of bronchial epithelial cells by activating p38 MAPK/MK2 signaling pathway

Fig. 4

Interference of FABP4 inhibits p38 MAPK/MK2 signaling pathway in 16HBE cells. Western blot analysis showed a suppression of CSE-mediated activation of p38 MAPK/MK2 signaling pathway in 16HBE cells transfected with shRNA-FABP4-1 as compared with the cells transfected with shRNA-NC. The normal 16HBE cells without transfection and CSE treatment were used as control. ***p < 0.001 vs. control group; ###p < 0.001 vs. 2% CSE + shRNA-NC group. 16HBE, Human bronchial epithelioid cell line; FABP4, Fatty Acid Binding Protein 4; p38, Mitogen-Activated Protein Kinase 14; p-p38, (Thr180/Tyr182); MK2, MAPK Activated Protein Kinase 2; p-MK2, (Thr334); GAPDH, Glyceraldehyde-3-Phosphate Dehydrogenase; CSE, cigarette smoke extract

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Journal of Inflammation

ISSN: 1476-9255

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