Skip to main content
Fig. 7 | Journal of Inflammation

Fig. 7

From: The functional characterization of phosphorylation of tristetraprolin at C-terminal NOT1-binding domain

Fig. 7

The TTP-CCR4-NOT-mRNA decay axis is regulated by Ser316 phosphorylation. A TTP interacts with CCR4-NOT deadenylase complex via CNOT1 under Ser316 unphosphorylated status. CNOT6 and CNTO7 would deadenylate TTP target ARE-containing mRNA such as TNFα and lead to mRNA decay. B RSK1 and MK2 are activated by inflammatory stimuli to phosphorylate Ser316, attenuating the interaction between TTP and CCR4-NOT complex. Ser178 is also phosphorylated to facilitate TTP and 14–3-3 interaction and independently inhibits the TTP-CCR4-NOT-mRNA decay axis

Back to article page