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Fig. 6 | Journal of Inflammation

Fig. 6

From: Dexmedetomidine hydrochloride inhibits hepatocyte apoptosis and inflammation by activating the lncRNA TUG1/miR-194/SIRT1 signaling pathway

Fig. 6

DEX inhibited OGD-induced hepatocyte injury via mediation of TUG1/miR-194/SIRT1 axis. WRL-68 cells were pre-treated with 1 nm DEX for 1 h and then cultured in OGD medium. (A) Cell viability was detected by MTT assay. (B) The apoptosis of WRL-68 cells was assessed by flow cytometry. (C) The protein expressions of Bcl-2 and Bax in WRL-68 cells were tested by western blotting. The relative protein expressions were quantified via normalizing to GAPDH. (D) The levels of inflammatory cytokines (IL-6, IL-1β and TNF-α) in supernatants of WRL-68 cells were assessed by ELISA. *p < 0.05, ** p < 0.01 and *** p < 0.001

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Journal of Inflammation

ISSN: 1476-9255

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