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Fig. 5 | Journal of Inflammation

Fig. 5

From: Dexmedetomidine hydrochloride inhibits hepatocyte apoptosis and inflammation by activating the lncRNA TUG1/miR-194/SIRT1 signaling pathway

Fig. 5

The protective effect of DEX against OGD-induced WRL-68 cell injury was reversed by miR-194 mimics. WRL-68 cells were pre-treated with 1 nm DEX for 1 h and then cultured in OGD medium. a Cell viability was assessed by MTT assay. b The apoptosis of WRL-68 cells was assessed by flow cytometry. c The protein expressions of Bcl-2 and Bax in WRL-68 cells were tested by western blotting. The relative protein expressions were quantified via normalizing to GAPDH. d The levels of inflammatory cytokines (IL-6, IL-1β and TNF-α) in supernatants of WRL-68 cells were assessed by ELISA. *p < 0.05, ** p < 0.01 and *** p < 0.001

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