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Fig. 6 | Journal of Inflammation

Fig. 6

From: AIM2 nuclear exit and inflammasome activation in chronic obstructive pulmonary disease and response to cigarette smoke

Fig. 6

Cigarette smoke extract (CS) induced AIM2 inflammasome activation in non-COPD non-smoker control BAL derived alveolar macrophages. a, b Representative confocal images of AIM2 (red, Ab #1, aa250–300/354) and cleaved IL-1β (green) in alveolar macrophages exposed to cigarette smoke extract (B), vs. vehicle control (a). c, d Quantitation of AIM2 and cleaved IL-1β specks (PPC, number of particles per cell) in cells treated with cigarette smoke extract (CSE) vs. vehicle control for paired analysis (n = 8). e Colocalization of cleaved IL-1β with ASC in CSE-treated alveolar macrophages

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