Fig. 8

Gene expression data showing upregulation of heme oxygenase 1 (HO1) by esomeprazole (100 μM) in human IPF lung fibroblasts. The data also shows that selective inhibition of MAP-ERK kinase 1/2 (MEK1/2) with U0126 (10 μM) impaired the induction of HO1 by esomeprazole. Data is Mean ± SEM from duplicate experiments. *p < 0.05 compared to esomeprazole alone