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Table 1 Study characteristics of the included studies on VEGF levels

From: RETRACTED ARTICLE: VEGF as a potential molecular target in periodontitis: a meta-analysis and microarray data validation

First author

Country

Ethnicity

Age

Method

Histology

Source of Ab

Staining

Case (N)

Control (N)

Case

Healthy control

Mean

SD

Mean

SD

Yuan 2000

China

Asian

32

IHC

Periodontitis

NA

Cytoplasm

15

15

0.6

0.27

0.38

0.21

Kubota 2001

Japan

Asian

28–42

RT-PCR

Aggressive periodontitis

NA

NA

6

8

5.34

1.36

3

1.27

Kubota 2001

Japan

Asian

55–71

RT-PCR

Chronic periodontitis

NA

NA

6

4.95

0.91

Lucarini 2009

Italy

European

47

IHC

Periodontitis

dil. 1:200; Santa Cruz Biotechnology, Santa Cruz, CA, USA

Epithelial cells

16

16

40

14.14

10

2.6

Artese 2010

Italy

European

<  35

IHC

Aggressive periodontitis

diluted at 1:100

Oral epithelium

6

7

74

2.28

27.85

1.95

Artese 2010

Italy

European

>  35

IHC

Chronic periodontitis

diluted at 1:100

Oral epithelium

14

56.28

3.51

Loo 2011

China

Asian

48

ELISA

Chronic periodontitis

Diaclone, France

NA

280

250

126.3

56.086

42.76

14.17

Kasprzak 2012

Poland

European

43

IHC

Chronic periodontitis

clone VG1, 1:50, DAKO

HEVs and ordinary/inflammatory infiltrate cells

40

15

3.57

5.02

0.02

0.04

Tian 2013

China

Asian

54

ELISA

Chronic periodontitis

Phoenix Pharmaceuticals, Inc., USA

NA

122

532

127.88

52.13

40.13

13.63

Balci 2019

Turkey

European

47.25

IHC

Chronic periodontitis

diluted 1:100, Abcam

Inflammatory cells

16

16

219.72

30.48

93.29

51.07

Taskan 2019

Turkey

European

40.37

IHC

Periodontitis (D-GradeB)

diluted 1:250

Inflammatory cells

15

15

98.74

3.73

122.7

17.37

Taskan 2019

Turkey

European

35.25

IHC

Periodontitis (D-GradeC)

diluted 1:250

Inflammatory cells

15

98.25

4.09

Li 2014

China

Asian

35–76

IHC

Chronic periodontitis

NA

Endothelial cells, stromal cells/inflammatory cells

15

15

83.53

7

41.87

5.97

  1. RT-PCR reverse transcription-polymerase chain reaction, ELISA enzyme-linked immunosorbent assay, IHC immunohistochemistry, Ab antibody, N the number of the study population, SD standard deviation