From: Effect of docosahexaenoic acid plus insulin on atherosclerotic human endothelial cells
Gene | Pal | Pal + DHA | DHA | Ins | Ins + Pal | Ins + Pal+ DHA | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Fold change | p Value | Fold change | p Value | Fold change | p Value | Fold change | p Value | Fold change | p Value | Fold change | p Value | |
FGA | 2.2623 | 0.000195 | 0.4162 | 0.000423 | 0.226 | 0.000122 | 0.9886 | 0.858718 | 2.7311 | 0.00034 | 1.2056 | 0.07855 |
ITGA2 | 0.5148 | 0.186216 | 0.0097 | 0.041603 | 0.013 | 0.041974 | 0.7513 | 0.393342 | 0.0295 | 0.043892 | 0.0209 | 0.04288 |
LPA | 0.1957 | 0.00154 | 0.036 | 0.000765 | 0.0639 | 0.000857 | 1.1497 | 0.286114 | 0.7457 | 0.081279 | 0.0684 | 0.00088 |
SERPINE1 | 0.2362 | 0.128603 | 0.0244 | 0.07897 | 0.018 | 0.077837 | 0.6983 | 0.389053 | 0.034 | 0.080701 | 0.5395 | 0.2671 |
APOA1 | 0.47 | 0.39454 | 1.4 | 0.6013 | 1.07 | 0.51948 | 0.37 | 0.37705 | 2.44 | 0.91345 | 1.28 | 0.57166 |
APOB | 0.24 | 0.00579 | 2.04 | 0.00380 | 0.64 | 0.06326 | 2.31 | 0.35248 | 6.02 | 0.00648 | 6. 86 | 0.25711 |
APOE | 0.73 | 0.42647 | 2.03 | 0.60903 | 2.2 | 0.63731 | 0.3 | 0.37543 | 0.56 | 0.41406 | 6.06 | 0.65791 |
COL3A1 | 0.1461 | 0.111593 | 0.5637 | 0.291867 | 0.3664 | 0.1846 | 0.6983 | 0.396531 | 0.8568 | 0.797511 | 0.6857 | 0.38775 |
ELN | 0.1418 | 0.004155 | 0.8408 | 0.310959 | 0.3837 | 0.013332 | 0.9063 | 0.507802 | 1.4722 | 0.059493 | 0.3476 | 0.01136 |
ENG | 0.2109 | 0.050585 | 0.1698 | 0.044254 | 0.2252 | 0.053022 | 0.7955 | 0.421651 | 0.773 | 0.3946 | 5.8257 | 0.00036 |
LPL | 0.0889 | 0.209023 | 0.6485 | 0.423387 | 0.7043 | 0.453014 | 0.5671 | 0.383148 | 0.3377 | 0.287539 | 0.4796 | 0.34411 |
NPY | 0.3719 | 0.100227 | 0.4571 | 0.130198 | 0.5653 | 0.183136 | 1.5873 | 0.323059 | 2.1488 | 0.064041 | 1.1366 | 0.95138 |
PDGFA | 0.3081 | 0.30454 | 0.2267 | 0.279675 | 0.2845 | 0.297106 | 0.527 | 0.381798 | 0.9322 | 0.569464 | 0.3387 | 0.31475 |
PDGFB | 0.4482 | 0.15356 | 0.0418 | 0.057159 | 0.0368 | 0.056512 | 1.7634 | 0.332943 | 1.4482 | 0.695445 | 0.0681 | 0.06075 |
PDGFRB | 0.1927 | 0.189131 | 0.1563 | 0.177984 | 0.1907 | 0.188486 | 0.6286 | 0.389363 | 0.5817 | 0.362109 | 0.4479 | 0.29033 |
VWF | 0.1548 | 0.349314 | 0.2082 | 0.356684 | 0.2419 | 0.361405 | 0.3421 | 0.375786 | 0.9787 | 0.479183 | 0.2582 | 0.36382 |
ACE | 2.6606 | 0.001328 | 126.1722 | 0.000001 | 1.3167 | 0.181824 | 1.2456 | 0.288333 | 2.8606 | 0.019744 | 3.5848 | 0.0008 |
SERPINB2 | 0.1631 | 0.273307 | 0.0315 | 0.240553 | 0.0392 | 0.242367 | 0.5069 | 0.379783 | 0.0439 | 0.243517 | 0.1127 | 0.26037 |
MMP1 | 1.2506 | 0.485206 | 0.0451 | 0.013016 | 0.0273 | 0.01227 | 1.3371 | 0.323544 | 0.0452 | 0.013028 | 0.0483 | 0.01316 |
MMP3 | 6.5663 | 0.000196 | 0.0976 | 0.044903 | 0.203 | 0.060289 | 1.5801 | 0.32596 | 0.2478 | 0.068863 | 0.1284 | 0.04895 |
FN1 | 0.2159 | 0.131015 | 0.0238 | 0.103147 | 0.0311 | 0.104081 | 2.9369 | 0.346906 | 0.1113 | 0.11499 | 0.2895 | 0.1439 |
PLIN2 | 0.4311 | 0.000402 | 0.5082 | 0.000732 | 0.5443 | 0.00106 | 1.0809 | 0.272634 | 0.6299 | 0.003951 | 0.3108 | 0.0002 |
CCL2 | 0.4282 | 0.005346 | 2.6829 | 0.000356 | 1.2678 | 0.0937 | 0.9466 | 0.615357 | 1.0125 | 0.949646 | 2.4055 | 0.00157 |
CCL5 | 0.2591 | 0.374313 | 0.2057 | 0.369794 | 0.1308 | 0.363532 | 0.2654 | 0.374848 | 1.8657 | 0.60549 | 0.6885 | 0.41259 |
CSF2 | 0.2711 | 0.025064 | 8.9048 | 0.000026 | 1.4678 | 0.133968 | 0.854 | 0.451294 | 0.3974 | 0.064759 | 3.0769 | 0.00183 |
CTGF | 0.2734 | 0.185923 | 5.6427 | 0.00221 | 1.0231 | 0.734643 | 0.661 | 0.392441- | 0.7044 | 0.427377 | 2.5402 | 0.10558 |
FGF2 | 0.0655 | 0.329726 | 0.231 | 0.354905 | 0.1689 | 0.345261 | 0.3622 | 0.376065 | 0.1476 | 0.34208 | 0.8251 | 0.45984 |
HBEGF | 0.0439 | 0.350439 | 0.1364 | 0.359529 | 0.1107 | 0.35698 | 0.2901 | 0.375072 | 1.2918 | 0.49116 | 0.2825 | 0.37437 |
IFNAR2 | 0.1335 | 0.108671 | 0.034 | 0.0873 | 0.0395 | 0.088357 | 0.6919 | 0.390488 | 0.0684 | 0.094137 | 0.4674 | 0.2339 |
IFNG | 0.4542 | 0.113708 | 0.0841 | 0.035513 | 0.014 | 0.029131 | 1.5025 | 0.337465 | 0.8758 | 0.489667 | 1.2179 | 0.81462 |
IL1A | 0.2709 | 0.016371 | 0.0605 | 0.007017 | 0.039 | 0.006489 | 0.8658 | 0.439692 | 1.0208 | 0.966917 | 0.591 | 0.08553 |
IL2 | 0.5464 | 0.172261 | 0.0619 | 0.041536 | 0.0276 | 0.03794 | 1.5729 | 0.33996 | 0.3901 | 0.106421 | 0.9203 | 0.54866 |
IL3 | 0.0619 | 0.063493 | 0.054 | 0.064519 | 0.0808 | 0.066625 | 0.7327 | 0.396901 | 0.3571 | 0.139598 | 0.1053 | 0.071 |
IL4 | 0.2308 | 0.070085 | 0.0373 | 0.039986 | 0.03 | 0.038965 | 0.7634 | 0.398858 | 0.0346 | 0.039484 | 0.041 | 0.0402 |
IL5 | 0.0346 | 0.003306 | 0.0138 | 0.003061 | 0.0342 | 0.003302 | 0.8838 | 0.434694 | 0.0347 | 0.003309 | 0.0687 | 0.00377 |
LAMA1 | 0.1693 | 0.11724 | 0.0677 | 0.100878 | 0.0136 | 0.093215 | 2.5196 | 0.346648 | 0.0217 | 0.09433 | 0.0184 | 0.09388 |
LIF | 0.2517 | 0.3286 | 0.2234 | 0.321968 | 0.1412 | 0.303453 | 0.4522 | 0.379005 | 0.2603 | 0.330848 | 0.1065 | 0.29603 |
SPP1 | 0.2781 | 0.126554 | 0.03 | 0.08018 | 0.0098 | 0.077336 | 2.1127 | 0.345463 | 0.0358 | 0.081029 | 0.0235 | 0.07926 |
THBS4 | 0.0522 | 0.319942 | 0.0953 | 0.32688 | 0.0409 | 0.318128 | 0.3809 | 0.376427 | 0.1226 | 0.331415 | 0.0294 | 0.31632 |
TNC | 0.0708 | 0.005068 | 0.0141 | 0.004107 | 0.0028 | 0.003942 | 0.8738 | 0.42883 | 0.5234 | 0.043917 | 0.0119 | 0.00408 |
VEGFA | 0.1601 | 0.115629 | 0.0772 | 0.102267 | 0.0239 | 0.094585 | 2.5196 | 0.34609 | 0.0267 | 0.094995 | 0.0319 | 0.09572 |
ABCA1 | 14.0178 | 0.000009 | 20.159 | 0.205066 | 3.49 | 0.000098 | 1.841 | 0.390056 | 0.4623 | 0.003394 | 7.7525 | 8.8E-05 |
LDLR | 0.365 | 0.038722 | 0.2613 | 0.025061 | 0.2554 | 0.024471 | 1.331 | 0.30633 | 0.8292 | 0.389805 | 0.3487 | 0.03658 |
FABP3 | 0.1018 | 0.008043 | 0.6334 | 0.103746 | 0.8515 | 0.390203 | 1.2744 | 0.300601 | 3.9597 | 0.000488 | 1.7359 | 0.03217 |
PPARA | 0.1982 | 0.007923 | 0.2181 | 0.008623 | 0.1571 | 0.006657 | 1.2399 | 0.297656 | 2.6329 | 0.001847 | 0.1282 | 0.00595 |
PTGS1 | 0.0477 | 0.022809 | 0.2276 | 0.041649 | 0.5146 | 0.124771 | 0.8139 | 0.429567 | 0.3359 | 0.062454 | 0.3187 | 0.05851 |
MSR1 | 0.1335 | 0.274678 | 0.4269 | 0.357643 | 0.4969 | 0.380583 | 0.4966 | 0.380455 | 0.2963 | 0.318531 | 0.5042 | 0.38355 |
NR1H3 | 0.2146 | 0.083775 | 0.482 | 0.182761 | 0.4682 | 0.175494 | 0.7548 | 0.411917 | 0.8595 | 0.557452 | 1.9049 | 0.12631 |
PPARD | 0.081 | 0.318945 | 0.0657 | 0.316328 | 0.0708 | 0.317195 | 0.3951 | 0.376967 | 0.2024 | 0.340457 | 0.2002 | 0.34006 |
PPARG | 0.7855 | 0.320083 | 0.0445 | 0.09 | 0.0142 | 0.085664 | 2.2941 | 0.341156 | 0.1837 | 0.113502 | 0.0115 | 0.08528 |
RXRA | 0.0533 | 0.331931 | 0.1001 | 0.338489 | 0.2671 | 0.362909 | 0.3524 | 0.375971 | 0.15 | 0.345694 | 0.4269 | 0.38787 |