Fig. 8
From: Pellino1 promoted inflammation in lung injury model of sepsis by TRAF6/ NF-κB signal pathway
The regulation of NF-κB participated in the effects of Pellino1 in mice model of lung injury model
NF-κB protein expressions (a, b), TNF-α, IL-6 levels, IL-1β and IL-18 levels (c, d, e, and f), lung tissue by HE assay (g), BAL neutrophil counts/mL (h), BAL protein concentrations (i), lung bacterial CFU/mL (j), circulating platelet counts (k), BAL fluid hemoglobin (l), BAL fluid OD540 measurements at 0 h (m) and Evans blue dye measurements of lung tissue homogenates at OD620 (n)
Model, sepsis model group (n = 6); Model + Pellino1, sepsis mice model by human recombinant Pellino1 protein group (n = 6); Model + Pellino1 + JSH-23, sepsis mice model by human recombinant Pellino1 protein and NF-κB inhibitor group (n = 6). Data are presented as means ± SD using ANOVA followed by Tukey’s post hoc test
##p < 0.01 compared with sepsis model group; **p < 0.01 compared with sepsis model by human recombinant Pellino1 protein group