Fig. 6
From: Pellino1 promoted inflammation in lung injury model of sepsis by TRAF6/ NF-κB signal pathway
The regulation of TRAF6 participated in the effects of Pellino1 in mice model of lung injury model
TRAF6 and NF-κB protein expressions (a, b, d), TNF-α level (c), lung tissue by HE assay (e), IL-6 levels, IL-1β and IL-18 levels (f, g, and h), BAL neutrophil counts/mL (i), BAL protein concentrations (j), lung bacterial CFU/mL (k), circulating platelet counts (l), BAL fluid hemoglobin (m), BAL fluid OD540 measurements at 0 h (n) and Evans blue dye measurements of lung tissue homogenates at OD620 (o)
Model, sepsis model group (n = 6); Model + Pellino1, sepsis mice model by human recombinant Pellino1 protein group (n = 6); Model + Pellino1 + C25-140, sepsis mice model by human recombinant Pellino1 protein and TRAF6 inhibitor group (n = 6). Data are presented as means ± SD using ANOVA followed by Tukey’s post hoc test
##i < 0.01 compared with sepsis model group; **p < 0.01 compared with sepsis model by human recombinant Pellino1 protein group