Fig. 1

SP1 and miR-205 were downregulated, PTEN was upregulated in of HK-2 cells exposed to anoxia-reoxygenation injury. The HK-2 cells were treated with anoxia-reoxygenation injury. a Cell proliferation was determined by MTT. b Cell apotosis was detected by flow cytometry analysis. c-d The expression of SP1, miR-205 and PTEN detected were detected by RT-qPCR. e Western blot detection of SP1, PTEN protein expression. f The secretion of IL-6 and TNF-α were detected by ELISA. The data are expressed as the mean ± SD and are representative of 3 experiments. *P < 0.05, **P < 0.01, ***P < 0.001