From: Role of melatonin in the angiogenesis potential; highlights on the cardiovascular disease
Study | Model | Outcome | Ref |
---|---|---|---|
Effect of melatonin implants in the proximal metaphyseal area of rabbit right tibia | In vivo | Vascular density↑ | [62] |
Application of melatonin in rat corneal micropocket assay and mouse model of indomethacin-induced gastric ulcers | In vivo | MMP-2↑, VEGF↑,MMP-14↑, TIMP-2↓ | [63] |
Intra-dermal administration of melatonin in rat model of dermal wound healing | In vivo | iNOS↓, Cyclooxygenase-2↑, VEGF↑, Hemoxygenase-1↑, Scar formation↓, | [64] |
Full-thickness incision in the model of mice | In vivo | Vascular units↑, Collagen fiber↑, hydroxyproline↑ | [65] |
Effect of melatonin on swine granulosa cells | In vitro | Proliferation↑, E2↑, P4↑, NO↓, Angiogenesis (Fibrin gel angiogenesis assay)↑ | [66] |
Effect of melatonin on human granulosa-lutein cell culture and Ovarian hyperstimulation syndrome | In vitro and In vivo | Follicular fluid MT2↑, P450 aromatase cytochrome↑, VEGF↑, iNOS↓ | [67] |
Inclusion of melatonin in collagen- poly(dialdehyde) gum acacia scaffold in rat model of excisional skin wound | In vivo | Re-epithelialization↑, Collagen deposition↑, Blood vessels formation↑ | [68] |
Protective effect of melatonin on EPCs after exposure to advanced glycation end product | In vitro and in vivo | EPC apoptosis↓, mitochondrial damage↓, Protective autophagy↑, tubulogenesis↑, Migration↑, AMPK/mTOR axis↑, α-SMA expressing cells↑, Collagen synthesis↑ | [69] |
Reno-protective effect of melatonin on early outgrowth EPCs | In vivo and In vitro | Renal function↑, TGF-β-induced apoptosis↓, VEGF secretion↑, Migration↑ | [45] |
Pre-treatment of adipose MSCs before administration into ischemic renal tissue | In vivo and In vitro | Cat activity↑, SOD activity↑, MSCs apoptosis↓, bFGF↑, HGF↑ | [70] |
Protective effect of melatonin on oxygen-glucose deprivation of brain microvascular cells | In vitro | ROS production↓, Claudin 5↑, VEGF↑, p-Akt/Akt ratio↑ | [71] |