Fig. 5
Primary tumor growth and the average lifespan of mice. The mice (n = 10) were challenged with an s.c. injection of 1 × 106 U251 cells into the left flank to induce a primary tumor model. a and b. 10 days after tumor challenge, Trimera mice were immunized s.c. in the base of the tail with 1 × 106 transduced DCs in 100 μl PBS for three times once a week. The average tumor volume and average lifespan of mice are depicted. c and d. 10 days after tumor challenge, Trimera mice were injected i.v. of 1× 107 lymphocytes. Control mice received the same volume of PBS. The tumor volume and mean lifespan of mice were observed. Experiments performed in triplicate showed consistent results