Fig. 3

Effect of LIUS stimulation on the vascular permeability. Evans Blue solution was intravenously administrated 30 min before the carrageenan injection with or without LIUS stimulation. Paw tissue was incubated with 10% neutral buffered formalin to extract extravasated Evans Blue. Optical density was measured at 630 nm and the measurements converted into ng dye extravasated per mg tissue. The extent of Evans Blue extravasation was evaluated at 1, 2 and 4 h after treatment in the saline, CRG and CRG + US groups. Data were presented as mean ± S.E. of 3 independent experiments (n = 3). *P < 0.05, ** P < 0.01, and *** P < 0.001 compared to the CRG group