Fig. 4
From: Circular RNA-CDR1as acts as the sponge of microRNA-641 to promote osteoarthritis progression
circRNA-CDR1as regulates the level of type II collagen, MMP13 and IL-6. a Changes in miR-641 abundance upon transfection with miR-641 inhibitors. MiR-641 abundance was determined by qRT-PCR. b-c The levels of MMP13, Col II and IL-6 were detected following transfection with circRNA-CDR1as, co-transfection with circRNA-CDR1as and the miR-641 inhibitor in chondrocytes. b The mRNA levels of MMP13, Col II and IL-6 were assessed by qRT-PCR. c The levels of MMP13 and Col II proteins were detected by western blot. Data are expressed as mean + SEM (n = 3). *p < 0.05 (t-test)