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Table 2 Comparison of tissue non-specific alkaline phosphatase (TNAP) mRNA expression

From: Tissue alkaline phosphatase activity and expression in an experimental infant swine model of cardiopulmonary bypass with deep hypothermic circulatory arrest

Tissue

TNAP Relative mRNA Levels by Intervention Group

Median (Intra-Quartile Range)

P value (Kruskal-Wallis)

AC (0)

CPB/DHCA (1)

CPB/DHCA + AP Low (2)

CPB/DHCA + AP Medium (3)

CPB/DHCA + AP High (4)

Kidney

1.03 (0.73–1.61)

1.42 (0.80–1.91)

0.65 (0.022–1.51)

1.00 (0.67–1.48)

0.80 (0.33–1.25)

0.51

Liver

1.01 (0.78–1.75)

1.28 (0.83–1.82)

0.94 (0.52–1.71)

1.67 (1.31–2.55)

1.48 (0.81–1.74)

0.42

Jejunum

1.00 (0.74–1.93)

1.35 (1.11–2.21)

1.56 (0.99–1.82)

1.13 (1.07–1.21)

1.07 (0.78–1.32)

0.41

Ileum

1.00 (0.25–2.11)

0.21 (0.15–3.84)

0.74 (0.58–0.81)

0.35 (0.19–0.58)

0.38 (0.16–0.53)

0.22

Colon

1.00 (0.70–1.33)

0.81 (0.69–1.55)

0.73 (0.47–1.20)

0.65 (0.39–0.84)

0.82 (0.80–0.99)

0.29

Lung-Apex

1.12 (0.41–2.47)

6.14 (4.02–11.06)

5.47 (1.65–19.57)

5.46 (1.87–9.61)

3.99 (1.91–5.40)

0.089

Lung-Lower Lobe

1.57 (1.04–2.13)

5.08 (2.44–13.11)

6.36 (4.95–11.76)

6.60 (1.19–9.21)

6.68 (3.62–7.94)

0.067

Heart

1.00 (0.45–1.64)

1.09 (0.64–1.36)

1.43 (0.85–1.53)

0.84 (0.71–1.72)

1.57 (0.55–2.32)

0.89

  1. Group 0 = Anesthesia controls (AC); Group 1 = Animals undergoing CBP/DHCA; Group 2 = Animals undergoing CPB/DHCA with low dose BiAP (3 U/kg bolus followed by 1 U/kg/hr. infusion); Group 3 = Animals undergoing CPB/DHCA with medium dose BiAP (15 U/kg bolus followed by 5 U/kg/hr. infusion); Group 4 = Animals undergoing CPB/DHCA with high dose BiAP (75 U/kg bolus followed by 25 U/kg/hr. infusion). Data are expressed as medians with intra-quartile ranges. Kruskal-Wallis test was performed