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Table 1 Comparison of tissue total alkaline phosphatase (AP) activity by intervention group

From: Tissue alkaline phosphatase activity and expression in an experimental infant swine model of cardiopulmonary bypass with deep hypothermic circulatory arrest

Tissue

Intervention Group

Total AP Activity (U/L)

Mean (SD)

P value (ANOVA)

Significant Post-HOC Group Comparisons

AC (0)

CPB/DHCA (1)

CPB/DHCA + AP Low (2)

CPB/DHCA + AP Medium (3)

CPB/DHCA + AP High (4)

Kidney

2211 (491)

1628 (472)

1536 (441)

1404 (165)

2028 (318)

0.01

0 vs. 1; 0 vs. 2; 0 vs. 3; 3 vs. 4

Liver

598 (115)

642 (161)

725 (100)

609 (161)

875 (146)

0.02

0 vs. 4; 1 vs. 4; 3 vs. 4

Jejunum

2160 (1162)

1460 (663)

1760 (477)

2292 (586)

2060 (877)

0.51

 

Ileum

1270 (432)

1016 (368)

982 (508)

1450 (1135)

1312 (332)

0.71

 

Colon

658 (327)

664 (435)

500 (97)

540 (238)

358 (185)

0.40

 

Lung-Apex

163 (79)

263 (153)

305 (108)

276 (82)

206 (57)

0.17

 

Lung-Lower Lobe

117 (46)

137 (21)

216 (85)

280 (38)

201 (57)

0.0003

0 vs. 2; 0 vs. 3; 0 vs. 4; 1 vs. 2; 1 vs. 3; 3 vs. 4

Heart

40 (12)

47 (15)

51 (19)

50 (10)

48 (8)

0.57

 
  1. Group 0 = Anesthesia controls (AC); Group 1 = Animals undergoing CBP/DHCA; Group 2 = Animals undergoing CPB/DHCA with low dose BiAP (3 U/kg bolus followed by 1 U/kg/hr. infusion); Group 3 = Animals undergoing CPB/DHCA with medium dose BiAP (15 U/kg bolus followed by 5 U/kg/hr. infusion); Group 4 = Animals undergoing CPB/DHCA with high dose BiAP (75 U/kg bolus followed by 25 U/kg/hr. infusion). Data are expressed as means (SD). One-way ANOVA was performed followed by post-hoc Student’s t-tests as appropriate. Bold: significant at p < 0.05