Fig. 4

Comparison of COX-2 protein expression in mouse uteruses among groups. No upregulation of COX-2 expression occurred in the saline group (β-actin used as control). Western blot analyses of COX-2 expression in mice co-stimulated with estradiol (0.2 mg/ml) and oxytocin (2 U/ml) in the PD group. A significant decrease of COX-2 protein expression occurred compared to the saline group. MCC950, an inhibitor of NLRP3, suppressed COX-2 protein expression. Data are expressed as means ± SD (n = 5). **P < 0.01 compared to the PD group