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Fig. 9 | Journal of Inflammation

Fig. 9

From: Enhanced inflammasome activation and reduced sphingosine-1 phosphate S1P signalling in a respiratory mucoobstructive disease model

Fig. 9

Hypothetical model of NLRP3 inflammasome activation and S1P signalling dysregulation in mucus-obstructed bronchioles. Unobstructed bronchioles (AIR): NLRP3 is mostly in monomeric state, only background levels of cleaved IL-1β are detected; SPHK1 generates cytosolic S1P, part of which is exported via SPNS2 for extracellular (inside-out) signalling via S1PRs; SPHK2 generates S1P mostly for intracellular signalling. Obstructed bronchioles (MUCUS): Increased oligomerization of NLRP3 (inflammasome activation) in either epithelium or infiltrating leucocytes results in IL-1β cleavage and increased luminal specks of NLRP3/IL-1β; decrease of SPNS2 and SPHK2 results in reduction of extra- and intracellular S1P signalling

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Journal of Inflammation

ISSN: 1476-9255

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