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Fig. 6 | Journal of Inflammation

Fig. 6

From: Enhanced inflammasome activation and reduced sphingosine-1 phosphate S1P signalling in a respiratory mucoobstructive disease model

Fig. 6

βENaC overexpression induced reduction of bronchiolar epithelial SPNS2 expression associated with mucus obstruction. a-d Representative confocal images of SPNS2 (green) in (a) wild type control, (b) βENaC unobstructed, versus (c) obstructed bronchiole; (d) a negative staining control showing no binding of AF488-conjugated anti-goat IgG. Blue is labelling of nuclei by DAPI. Scale bars are in micrometers. e Box plot represents MFI values of SPNS2 expression measured from individual βENaC mice, unobstructed (red) versus mucus obstructed (green) bronchioles. Mann-Whitney, * p < 0.05. Each dot represents the average of 10 bronchioles

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Journal of Inflammation

ISSN: 1476-9255

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