Fig. 1
From: MiRNA-494 enhances M1 macrophage polarization via Nrdp1 in ICH mice model
MiR-494 levels increased in erythrocyte lysates-treated macrophages and perihematomatissue of ICH mice. a Macrophages (1 × 105) were administrated with 10 μl PBS or erythrocyte lysates for 1, 3, or 5 days. After then, the cell lysates were further analyzed for miR-494 mRNA levels. The level of miR-494 in erythrocyte lysates treated macrophages was much higher than that in PBS treated group at different time point in observation. *P < 0.05. b Mice were deeply anaesthetized and transcardially at 1, 3, or 5 days after ICH. The perihaematomal region of cerebral tissue was collected, and the tissue lysates were further analyzed for miR-494 mRNA levels. MiR-494 level in perihematoma tissue of ICH was much higher than that in sham group. Experiments performed in triplicate showed consistent results. The differences were analyzed using ANOVA. *P < 0.05