TY - JOUR AU - Yoon, Sae-Bom AU - Lee, Chang Hoon AU - Kim, Hyun Young AU - Jeong, Daeyoung AU - Jeon, Moon Kook AU - Cho, Sun-A AU - Kim, Kwangmi AU - Lee, Taeho AU - Yang, Jung Yoon AU - Gong, Young-Dae AU - Cho, Heeyeong PY - 2020 DA - 2020/05/29 TI - A novel sphingosylphosphorylcholine and sphingosine-1-phosphate receptor 1 antagonist, KRO-105714, for alleviating atopic dermatitis JO - Journal of Inflammation SP - 20 VL - 17 IS - 1 AB - Atopic dermatitis (eczema) is a type of inflammation of the skin, which presents with itchy, red, swollen, and cracked skin. The high global incidence of atopic dermatitis makes it one of the major skin diseases threatening public health. Sphingosylphosphorylcholine (SPC) and sphingosine-1-phosphate (S1P) act as pro-inflammatory mediators, as an angiogenesis factor and a mitogen in skin fibroblasts, respectively, both of which are important biological responses to atopic dermatitis. The SPC level is known to be elevated in atopic dermatitis, resulting from abnormal expression of sphingomyelin (SM) deacylase, accompanied by a deficiency in ceramide. Also, S1P and its receptor, sphingosine-1-phosphate receptor 1 (S1P1) are important targets in treating atopic dermatitis. SN - 1476-9255 UR - https://doi.org/10.1186/s12950-020-00244-6 DO - 10.1186/s12950-020-00244-6 ID - Yoon2020 ER -