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Fig. 2 | Journal of Inflammation

Fig. 2

From: Urolithin a attenuates IL-1β-induced inflammatory responses and cartilage degradation via inhibiting the MAPK/NF-κB signaling pathways in rat articular chondrocytes

Fig. 2

Effect of UA on IL-1β induced expression of iNOS, COX2, and MMPs. Chondrocytes were treated with IL-1β (20 ng/ml) alone or UA (1, 7.5 and 15 μM) in combination with IL-1β (20 ng/ml) for 48 h. a Protein expression of iNOS, COX2, MMP3, and MMP13 were determined by western blot. b, c, d, e Relative protein expression of iNOS, COX2, MMP3, and MMP13 shown as histograms. f, g, h Relative gene expression of MMP9, ADAMTS4, and Collagen 2a1 were measured by RT-qPCR. Data are presented as mean ± S.D. n = 6. *P < 0.05, **P < 0.01, ***P < 0.001 versus the IL-1β group

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Journal of Inflammation

ISSN: 1476-9255

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