Table 2 Meta-analysis of the association between IL-10 polymorphisms and BD risk
polymorphism | No. of studies | Comparison | Test of association | Test of heterogeneity | Egger’s test (P) | Metareg’s test (P) | |||
|---|---|---|---|---|---|---|---|---|---|
OR (95% CI) | P-value | P- value | I2 (%) | Q test | |||||
rs1800896 A/G | 10 | GG vs. AA | 0.925 (0.684–1.251) | 0.613 | 0.266 | 19.9 | 9.98 | 0.746 | 0.689 |
GG + GA vs. AA | 0.936 (0.733–1.195) | 0.596 | 0.020 | 56/0 | 18.20 | 0.836 | 0.866 | ||
GG vs. GA + AA | 0.975 (0.660–1.441) | 0.900 | 0.025 | 54.4 | 17.55 | 0.619 | 0.640 | ||
AG vs. AA | 0.945 (0.717–1.245) | 0.687 | 0.007 | 62.2 | 21.17 | 0.822 | 0.870 | ||
G vs. A | 0.965 (0.831–1.120) | 0.640 | 0.084 | 41.0 | 15.25 | 0.816 | 0.807 | ||
rs1800871 T/C | 19 | CC vs. TT | 0.466 (0.368–0.589) | 0.000 | 0.003 | 57.4 | 32.88 | 0.081 | 0.347 |
CC + CT vs. TT | 0.692 (0.584–0.820) | 0.000 | 0.000 | 66.1 | 41.33 | 0.842 | 0.674 | ||
CC vs. CT + TT | 0.557 (0.405–0.767) | 0.000 | 0.000 | 86.6 | 119.02 | 0.032 | 0.123 | ||
CT vs. TT | 0.842 (0.572–1.240) | 0.384 | 0.000 | 93.7 | 220.52 | 0.542 | 0.883 | ||
C vs. T | 0.691 (0.626–0.762) | 0.000 | 0.000 | 67.8 | 49.73 | 0.363 | 0.493 | ||
rs1800872 A/C | 13 | CC vs. AA | 0.723 (0.440–1.186) | 0.199 | 0.000 | 72.4 | 32.63 | 0.161 | 0.360 |
CC + CA vs. AA | 0.713 (0.535–0.951) | 0.021 | 0.004 | 62.4 | 23.94 | 0.116 | 0.276 | ||
CC vs. CA + AA | 0.776 (0.583–1.032) | 0.082 | 0.004 | 60.3 | 27.71 | 0.210 | 0.367 | ||
CA vs. AA | 0.716 (0.546–0.940) | 0.016 | 0.024 | 53.0 | 19.13 | 0.101 | 0.313 | ||
C vs. A | 0.779 (0.662–0.915) | 0.002 | 0.000 | 70.2 | 33.59 | 0.194 | 0.423 | ||
rs1518111 A/G | 13 | GG vs. AA | 0.570 (0.471–0.690) | 0.000 | 0.459 | 0.0 | 1.56 | 0.622 | 0.741 |
GG + GA vs. AA | 0.697)0.596–0.814) | 0.000 | 0.393 | 0.0 | 1.87 | 0.684 | 0.533 | ||
GG vs. GA + AA | 0.701 (0.623–0.790) | 0.000 | 0.505 | 0.0 | 3.32 | 0.558 | 0.967 | ||
AG vs. AA | 0.786 (0.667–0.927) | 0.004 | 0.723 | 0.0 | 0.65 | 0.604 | 0.645 | ||
G vs. A | 0.738 (0.681–0.800) | 0.000 | 0.106 | 36.7 | 15.79 | 0.500 | 0.352 | ||
rs1554286 T/C | 3 | CC vs. TT | 0.508 (0.372–0.694) | 0.000 | 0.198 | 38.2 | 3.23 | 0.795 | 0.868 |
CC + CT vs. TT | 0.605)0.467–0.785( | 0.000 | 0.087 | 59.1 | 4.89 | 0.626 | 0.466 | ||
CC vs. CT + TT | 0.665)0.484–0.916( | 0.012 | 0.041 | 68.7 | 6.40 | 0.487 | 0.893 | ||
CT vs. TT | 0.646 (0.502–0.832) | 0.001 | 0.115 | 53.8 | 4.33 | 0.656 | 0.506 | ||
C vs. T | 0.582 (0.440–0.770) | 0.000 | 0.000 | 87.7 | 16.23 | 0.384 | 0.265 | ||