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Fig. 1 | Journal of Inflammation

Fig. 1

From: The double edge of anti-CD40 siRNA therapy: It increases renal microcapillar density but favours the generation of an inflammatory milieu in the kidneys of ApoE−/− mice

Fig. 1

Anti-CD40 siRNA treatment increases microcapillar density in kidneys from ApoE-deficient mice. Representative images of the anti-CD31(PCAM-1)/haematoxylin staining of kidney sections from ApoE−/− mice treated with: a control vehicle (Veh), b a control sequence-scrambled siRNA (siSC), or c the anti-CD40 siRNA (siCD40), at 200x magnification (Scale bars are 100 µm). To increase contrast and facilitate visualization, endothelial cells (EC) were stained in false red with ImageJ. G shows the renal glomeruli and the arrows some EC. d Box-plot showing the proportion of vessel area density per kidney section (see Material and Methods for details on the measurement). Each diagram represents the median, quartiles and outliers. The colored box represents the interquartile range that contains 50% of the values. The whiskers are lines that extended from the box to the highest and lowest values, excluding outliers. A line across the box represents the median value. Kruskal Wallis test

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